Benjamin M Stutchfield, Daniel J Antoine, Alison C Mackinnon, Deborah J Gow, Calum C Bain, Catherine A Hawley, Michael J Hughes, Benjamin Francis, Davina Wojtacha, Tak Y Man, James W Dear, Luke R Devey, Alan M Mowat, Jeffrey W Pollard, B Kevin Park, Stephen J Jenkins, Kenneth J Simpson, David A Hume, Stephen J Wigmore, Stuart J Forbes
BACKGROUND & AIMS: Liver regeneration requires functional liver macrophages, which provide an immune barrier that is compromised after liver injury. The numbers of liver macrophages are controlled by macrophage colony-stimulating factor (CSF1). We examined the prognostic significance of the serum level of CSF1 in patients with acute liver injury and studied its effects in mice. METHODS: We measured levels of CSF1 in serum samples collected from 55 patients who underwent partial hepatectomy at the Royal Infirmary Edinburgh between December 2012 and October 2013, as well as from 78 patients with acetaminophen-induced acute liver failure admitted to the Royal Infirmary Edinburgh or the University of Kansas Medical Centre...
December 2015: Gastroenterology