Freja Drost Andersen, Sâmia Joca, Victor Hvingelby, Shokouh Arjmand, Estefano Pinilla, Simon Comerma Steffensen, Ulf Simonsen, Charlotte Uggerhøj Andersen
Fatal opioid poisonings often involve methadone or morphine. This study aimed to elucidate if quetiapine, a widely used sedative antipsychotic medication, may increase the risk of fatal opioid poisoning by additive inhibitory effects on the central nervous system. We used data from 323 cases of fatal methadone or/and morphine poisonings autopsied from 2013 to 2020, a survey of 34 drug users, and performed blinded placebo-controlled studies in 75 Flinders Resistant Line rats receiving three cumulative intraperitoneal doses of vehicle, methadone (2...
September 2022: Addiction Biology