Thierry Conrozier, Jean-Charles Balblanc, Pascal Richette, Denis Mulleman, Bernard Maillet, Yves Henrotin, Francois Rannou, Catherine Piroth, Pascal Hilliquin, Pierre Mathieu, Anne Walliser-Lohse, Isabelle Rousselot, Valerie Plattner, Jean-Francis Maillefert, Eric Vignon, Xavier Chevalier
The aim of the study was to investigate the effect of hyaluronic acid (HA) intra articular injections (IA) on osteoarthritis (OA) biomarkers in patients with knee OA. Prospective open label study. Fifty-one patients with unilateral symptomatic K-OA received IA injections of 2mL of HA on days (D) 1, 7, 14 and were followed 3 months. At D-15 patients were examined and X-rays performed, to exclude patients with bilateral K-OA, or those with more than three symptomatic OA joints. From 15 days (D-15) before the first injection to D90 concomitant therapies were unchanged...
May 2012: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society