Sara E Arian, Linnea Goodman, Rebecca L Flyckt, Tommaso Falcone
OBJECTIVE: To describe and demonstrate a novel surgical method for laparoscopic ovarian transposition. In this video, we present a unique minimally invasive technique for transposing the ovaries, whereby the ovary is tunneled through the peritoneum. DESIGN: Video presentation of clinical article. The video uses animations and a surgical case to demonstrate the detailed surgical technique for laparoscopic ovarian transposition with a unique feature. Institutional review board approval was not required for this video presentation...
April 2017: Fertility and Sterility
M Nickkho-Amiry, R Savant, K Majumder, E Edi-O'sagie, M Akhtar
OBJECTIVE: To assess the impact of surgical management of endometrioma on the outcome of assisted reproduction treatment (ART). DESIGN: A systematic review and meta-analysis. SETTING: Department of reproductive medicine at teaching university hospital, UK. PATIENTS: Subfertile women with endometrioma undergoing ART. INTERVENTIONS: Surgical removal of endometrioma or expectant management. MAIN OUTCOME MEASURES: Clinical pregnancy rate, pregnancy rate, live birth rate, number of oocytes retrieved and number of embryos available and ovarian response to gonadotrophins...
April 2018: Archives of Gynecology and Obstetrics
Zi-Jiang Chen, Yuhua Shi, Yun Sun, Bo Zhang, Xiaoyan Liang, Yunxia Cao, Jing Yang, Jiayin Liu, Daimin Wei, Ning Weng, Lifeng Tian, Cuifang Hao, Dongzi Yang, Feng Zhou, Juanzi Shi, Yongle Xu, Jing Li, Junhao Yan, Yingying Qin, Han Zhao, Heping Zhang, Richard S Legro
BACKGROUND: The transfer of fresh embryos is generally preferred over the transfer of frozen embryos for in vitro fertilization (IVF), but some evidence suggests that frozen-embryo transfer may improve the live-birth rate and lower the rates of the ovarian hyperstimulation syndrome and pregnancy complications in women with the polycystic ovary syndrome. METHODS: In this multicenter trial, we randomly assigned 1508 infertile women with the polycystic ovary syndrome who were undergoing their first IVF cycle to undergo either fresh-embryo transfer or embryo cryopreservation followed by frozen-embryo transfer...
August 11, 2016: New England Journal of Medicine
John Zhang
Minimal stimulation in vitro fertilization (mini-IVF) consists of a gentle controlled ovarian stimulation that aims to produce a maximum of five to six oocytes. There is a misbelief that mini-IVF severely compromises pregnancy and live birth rates. An appraisal of the literature pertaining to studies on mini-IVF protocols was performed. The advantages of minimal stimulation protocols are reported here with a focus on the use of clomiphene citrate (CC), gonadotropin releasing hormone (GnRH) ago- nist trigger for oocyte maturation, and freeze-all embryo strategy...
July 2016: International Journal of Fertility & Sterility
Wael A Ismail Madkour, Bassel Noah, Amr M S Abdel Hamid, Hena Zaheer, Awatif Al-Bahr, Mahmoud Shaeer, Ashraf Moawad
In vitro fertilization (IVF) cycles are associated with a defective luteal phase. Although progesterone supplementation to treat this problem is standard practice, estrogen addition is debatable. Our aim was to compare pregnancy outcomes in 220 patients undergoing antagonist intracytoplasmic sperm injection (ICSI) cycles protocol. The patients were randomly assigned into two equal groups to receive either vaginal progesterone alone (90 mg once daily) starting on the day of oocyte retrieval for up to 12 weeks if pregnancy occurred or estradiol addition (2 mg twice daily) starting on the same day and continuing up to seven weeks (foetal viability scan)...
June 2016: Human Fertility: Journal of the British Fertility Society
Maria C Krog, Henriette Svarre Nielsen, Ole B Christiansen, Astrid M Kolte
Endocrine disruptions may be important in patients experiencing recurrent pregnancy loss (RPL). This review focuses on data available on RPL and the endocrine system to investigate relevant, and perhaps modifiable, endocrine factors of importance for the disorder. Evidence indicates that some hormones may be important as immune modulators and a better understanding of this interplay has potential for improving pregnancy outcome in RPL. To date there is a lack of consensus on the effect of endocrine treatment options in RPL and there is a strong need for large randomized-controlled trials...
September 2016: Clinical Obstetrics and Gynecology
Panagiotis Drakopoulos, Christophe Blockeel, Dominic Stoop, Michel Camus, Michel de Vos, Herman Tournaye, Nikolaos P Polyzos
STUDY QUESTION: What is the impact of ovarian response on cumulative live birth rates (LBR) following utilization of all fresh and frozen embryos in women undergoing their first ovarian stimulation cycle, planned to undergo single embryo transfer (SET). SUMMARY ANSWER: Cumulative LBR significantly increases with the number of oocytes retrieved. WHAT IS KNOWN ALREADY: Several studies have addressed the issue of the optimal number of oocytes retrieved following controlled ovarian stimulation (COS) for IVF/ICSI and demonstrated that ovarian response is independently related to LBR following IVF/ICSI...
February 2016: Human Reproduction
Christopher R McCartney, John C Marshall
A 22-year-old woman reports having hirsutism and irregular menses. She describes unpredictable and infrequent menses (five or six per year) since menarche at 11 years of age. Dark, coarse facial hair began to develop at 13 years of age. The symptoms worsened after she gained weight in college. The physical examination includes a body-mass index (BMI; the weight in kilograms divided by the square of the height in meters) of 29, blood pressure of 135/85 mm Hg, and moderate hirsutism without virilization. Laboratory tests reveal a total testosterone level of 65 ng per deciliter (2...
July 7, 2016: New England Journal of Medicine
Tarek Shokeir, Mohamed Ebrahim, Hosam El-Mogy
AIM: To evaluate the efficacy of a hysteroscopic site-specific local endometrial injury (LEI) in a group of women with unexplained infertility (UI) undergoing expectant management with no fertility treatment versus no intervention. METHODS: This open-label, randomized controlled trial (RCT) was conducted between June 2013 and July 2015. Hysteroscopic site-specific LEI was determined by patient identification number, and 120 women were included. Eligible participants were randomly assigned to receive either a single, site-specific LEI guided by hysteroscopy (study group, n = 60) or no intervention (control group, n = 60)...
November 2016: Journal of Obstetrics and Gynaecology Research
Monya Baker
No abstract text is available yet for this article.
March 10, 2016: Nature
Mohamed A Youssef, Ahmed M Abou-Setta, Wai Sun Lam
BACKGROUND: For the last few decades urinary human chorionic gonadotrophin (uhCG) has been used to trigger final oocyte maturation in cycles of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Recombinant technology has allowed the production of two drugs, recombinant human chorionic gonadotrophin (rhCG) and recombinant luteinising hormone (rLH), that can be used for the same purpose, to mimic the endogenous luteinising hormone (LH) surge. This allows commercial manufacturers to adjust production according to market requirements and to remove all urinary contaminants, facilitating the safe subcutaneous administration of a compound with less batch-to-batch variation...
April 23, 2016: Cochrane Database of Systematic Reviews
Xi Yuan, Sotirios H Saravelos, Qiong Wang, Yanwen Xu, Tin-Chiu Li, Canquan Zhou
This retrospective study assessed the predictive value of endometrial thickness (EMT) on HCG administration day for the clinical outcome of fresh IVF and intracytoplasmic sperm injection (ICSI) cycles. A total of 8690 consecutive women undergoing 10,787 cycles over a 5-year period were included. The 5th, 50th and 95th centiles for EMT were determined as 8, 11 and 15 mm, respectively. Group analysis according to these centiles (Group 1: < 8 mm; Group 2: ≥ 8 and ≤11 mm; Group 3: > 11 and ≤15 mm; Group 4: > 15 mm) demonstrated significant differences (P < 0...
August 2016: Reproductive Biomedicine Online
Hesham G Al-Inany, Mohamed A Youssef, Reuben Olugbenga Ayeleke, Julie Brown, Wai Sun Lam, Frank J Broekmans
BACKGROUND: Gonadotrophin-releasing hormone (GnRH) antagonists can be used to prevent a luteinizing hormone (LH) surge during controlled ovarian hyperstimulation (COH) without the hypo-oestrogenic side-effects, flare-up, or long down-regulation period associated with agonists. The antagonists directly and rapidly inhibit gonadotrophin release within several hours through competitive binding to pituitary GnRH receptors. This property allows their use at any time during the follicular phase...
April 29, 2016: Cochrane Database of Systematic Reviews
Ningxin Qin, Qiuju Chen, Qingqing Hong, Renfei Cai, Hongyuan Gao, Yun Wang, Lihua Sun, Shaozhen Zhang, Haiyan Guo, Yonglun Fu, Ai Ai, Hui Tian, Qifeng Lyu, Salim Daya, Yanping Kuang
OBJECTIVE: To investigate flexibility in starting controlled ovarian stimulation at any phase of the menstrual cycle in infertile women undergoing treatment with assisted reproduction. DESIGN: Retrospective cohort study. SETTING: Academic tertiary-care medical center. PATIENT(S): At total of 150 infertile patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment. Ninety of the women also underwent frozen embryo transfer (FET) procedures...
August 2016: Fertility and Sterility
Janet F McLaren, Richard O Burney, Amin A Milki, Lynn M Westphal, Michael H Dahan, Ruth B Lathi
OBJECTIVE: To evaluate the pregnancy rate, ovarian responsiveness, and endometrial thickness in infertility patients with a history of methotrexate exposure who subsequently underwent controlled ovarian stimulation. DESIGN: Retrospective cohort study. SETTING: University reproductive endocrinology and infertility program. SUBJECT(S): Forty-eight women with infertility undergoing ovarian stimulation after receiving methotrexate treatment for ectopic gestation...
August 2009: Fertility and Sterility
Christina E Boots, Robert L Gustofson, Eve C Feinberg
OBJECTIVE: To evaluate the effects of methotrexate (MTX) on the future fertility of women undergoing IVF by comparing ovarian reserve and ovarian responsiveness in the IVF cycle before and after an ectopic pregnancy (EP) treated with MTX. DESIGN: Retrospective cohort study. SETTING: Private reproductive endocrinology and infertility practice. PATIENT(S): Sixty-six women undergoing IVF before and after receiving MTX for an EP...
December 2013: Fertility and Sterility
Nigel Pereira, Deanna Gerber, Rachel S Gerber, Jovana P Lekovich, Rony T Elias, Steven D Spandorfer, Zev Rosenwaks
OBJECTIVE: To investigate the effect of methotrexate (MTX) or salpingectomy for ectopic pregnancy on the outcomes of subsequent in vitro fertilization (IVF)-embryo transfer (ET) cycles. DESIGN: Retrospective cohort study (Canadian Task Force Classification II-3). SETTING: Academic center. PATIENTS: All patients undergoing fresh IVF-ET between January 2004 and July 2013 after treatment of an ectopic pregnancy with MTX or salpingectomy in the preceding IVF-ET cycle were analyzed for potential inclusion...
July 2015: Journal of Minimally Invasive Gynecology
Arri Coomarasamy, Helen Williams, Ewa Truchanowicz, Paul T Seed, Rachel Small, Siobhan Quenby, Pratima Gupta, Feroza Dawood, Yvonne E M Koot, Ruth Bender Atik, Kitty W M Bloemenkamp, Rebecca Brady, Annette L Briley, Rebecca Cavallaro, Ying C Cheong, Justin J Chu, Abey Eapen, Ayman Ewies, Annemieke Hoek, Eugenie M Kaaijk, Carolien A M Koks, Tin-Chiu Li, Marjory MacLean, Ben W Mol, Judith Moore, Jackie A Ross, Lisa Sharpe, Jane Stewart, Nirmala Vaithilingam, Roy G Farquharson, Mark D Kilby, Yacoub Khalaf, Mariette Goddijn, Lesley Regan, Rajendra Rai
BACKGROUND: Progesterone is essential for the maintenance of pregnancy. However, whether progesterone supplementation in the first trimester of pregnancy would increase the rate of live births among women with a history of unexplained recurrent miscarriages is uncertain. METHODS: We conducted a multicenter, double-blind, placebo-controlled, randomized trial to investigate whether treatment with progesterone would increase the rates of live births and newborn survival among women with unexplained recurrent miscarriage...
November 26, 2015: New England Journal of Medicine
Laura Spencer, Tanya Bubner, Emily Bain, Philippa Middleton
BACKGROUND: Thyroid dysfunction pre-pregnancy and during pregnancy (both hyper- and hypothyroidism) is associated with increased risk of adverse outcomes for mothers and infants in the short- and long-term. Managing the thyroid dysfunction (e.g. thyroxine for hypothyroidism, or antithyroid medication for hyperthyroidism) may improve outcomes. The best method of screening to identify and subsequently manage thyroid dysfunction pre-pregnancy and during pregnancy is unknown. OBJECTIVES: To assess the effects of different screening methods (and subsequent management) for thyroid dysfunction pre-pregnancy and during pregnancy on maternal and infant outcomes...
September 21, 2015: Cochrane Database of Systematic Reviews
M Kollmann, W P Martins, M L S Lima, L Craciunas, C O Nastri, A Richardson, N Raine-Fenning
OBJECTIVES: To identify, appraise and summarize the current evidence regarding the efficacy of strategies aimed at improving assisted reproductive techniques in women with polycystic ovary syndrome (PCOS). METHODS: A comprehensive literature search of the standard medical databases was performed. The last electronic search was run in July 2015. The primary outcome measures were live birth/ongoing pregnancy and ovarian hyperstimulation syndrome (OHSS). The secondary outcome measures were clinical pregnancy and miscarriage...
December 2016: Ultrasound in Obstetrics & Gynecology
2016-03-19 15:07:26
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