Stephanie G Dakin, Fernando O Martinez, Clarence Yapp, Graham Wells, Udo Oppermann, Benjamin J F Dean, Richard D J Smith, Kim Wheway, Bridget Watkins, Lucy Roche, Andrew J Carr
Improved understanding of the role of inflammation in tendon disease is required to facilitate therapeutic target discovery. We studied supraspinatus tendons from patients experiencing pain before and after surgical subacromial decompression treatment. Tendons were classified as having early, intermediate, or advanced disease, and inflammation was characterized through activation of pathways mediated by interferon (IFN), nuclear factor κB (NF-κB), glucocorticoid receptor, and signal transducer and activator of transcription 6 (STAT-6)...
October 28, 2015: Science Translational Medicine