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ER Stress and Pain

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5 papers 0 to 25 followers
Enji Zhang, Min-Hee Yi, Nara Shin, Hyunjung Baek, Sena Kim, Eunjee Kim, Kisang Kwon, Sunyeul Lee, Hyun-Woo Kim, Yong Chul Bae, Yonghyun Kim, O-Yu Kwon, Won Hyung Lee, Dong Woon Kim
Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, but its role in neuropathic pain remains unclear. In this study, we examined the ER stress and the unfolded protein response (UPR) activation in a L5 spinal nerve ligation (SNL)-induced rat neuropathic pain model. SNL-induced neuropathic pain was assessed behaviorally using the CatWalk system, and histologically with microglial activation in the dorsal spinal horn. L5 SNL induced BIP upregulation in the neuron of superficial laminae of dorsal spinal horn...
June 25, 2015: Scientific Reports
Eun Sun Yang, Jin Young Bae, Tae Heon Kim, Yun Sook Kim, Kyoungho Suk, Yong Chul Bae
Endoplasmic reticulum (ER) stress is involved in many neurological diseases and inflammatory responses. Inflammatory mediators induce neuronal damage and trigger the neuropathic or inflammatory pain. But there is very little data on the role of the ER stress response in pain mechanisms. In this study, we explored whether the ER stress response is involved in orofacial inflammatory pain by using a complete Freund's adjuvant (CFA)-injected rat model. The thermal pain hypersensitivity increased significantly after CFA injection...
December 2014: Experimental Neurobiology
Phillipe D O'Brien, Lucy M Hinder, Stacey A Sakowski, Eva L Feldman
SIGNIFICANCE: Diabetes and other diseases that comprise the metabolic syndrome have reached epidemic proportions. Diabetic peripheral neuropathy (DPN) is the most prevalent complication of diabetes, affecting ~50% of diabetic patients. Characterized by chronic pain or loss of sensation, recurrent foot ulcerations, and risk for amputation, DPN is associated with significant morbidity and mortality. Mechanisms underlying DPN pathogenesis are complex and not well understood, and no effective treatments are available...
August 1, 2014: Antioxidants & Redox Signaling
M Mecha, A S Torrao, L Mestre, F J Carrillo-Salinas, R Mechoulam, C Guaza
Cannabidiol (CBD) is the most abundant cannabinoid in Cannabis sativa that has no psychoactive properties. CBD has been approved to treat inflammation, pain and spasticity associated with multiple sclerosis (MS), of which demyelination and oligodendrocyte loss are hallmarks. Thus, we investigated the protective effects of CBD against the damage to oligodendrocyte progenitor cells (OPCs) mediated by the immune system. Doses of 1 μM CBD protect OPCs from oxidative stress by decreasing the production of reactive oxygen species...
2012: Cell Death & Disease
Bora Inceoglu, Ahmed Bettaieb, Carlos A Trindade da Silva, Kin Sing Stephen Lee, Fawaz G Haj, Bruce D Hammock
Despite intensive effort and resulting gains in understanding the mechanisms underlying neuropathic pain, limited success in therapeutic approaches have been attained. A recently identified, nonchannel, nonneurotransmitter therapeutic target for pain is the enzyme soluble epoxide hydrolase (sEH). The sEH degrades natural analgesic lipid mediators, epoxy fatty acids (EpFAs), therefore its inhibition stabilizes these bioactive mediators. Here we demonstrate the effects of EpFAs on diabetes induced neuropathic pain and define a previously unknown mechanism of pain, regulated by endoplasmic reticulum (ER) stress...
July 21, 2015: Proceedings of the National Academy of Sciences of the United States of America
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