Enji Zhang, Min-Hee Yi, Nara Shin, Hyunjung Baek, Sena Kim, Eunjee Kim, Kisang Kwon, Sunyeul Lee, Hyun-Woo Kim, Yong Chul Bae, Yonghyun Kim, O-Yu Kwon, Won Hyung Lee, Dong Woon Kim
Endoplasmic reticulum (ER) stress has been implicated in neurodegenerative diseases, but its role in neuropathic pain remains unclear. In this study, we examined the ER stress and the unfolded protein response (UPR) activation in a L5 spinal nerve ligation (SNL)-induced rat neuropathic pain model. SNL-induced neuropathic pain was assessed behaviorally using the CatWalk system, and histologically with microglial activation in the dorsal spinal horn. L5 SNL induced BIP upregulation in the neuron of superficial laminae of dorsal spinal horn...
June 25, 2015: Scientific Reports