collection
https://read.qxmd.com/read/38491741/obesity-the-perfect-storm-for-heart-failure
#1
REVIEW
Maria Lembo, Teresa Strisciuglio, Celeste Fonderico, Costantino Mancusi, Raffaele Izzo, Valentina Trimarco, Alessandro Bellis, Emanuele Barbato, Giovanni Esposito, Carmine Morisco, Speranza Rubattu
Obesity condition causes morphological and functional alterations involving the cardiovascular system. These can represent the substrates for different cardiovascular diseases, such as atrial fibrillation, coronary artery disease, sudden cardiac death, and heart failure (HF) with both preserved ejection fraction (EF) and reduced EF. Different pathogenetic mechanisms may help to explain the association between obesity and HF including left ventricular remodelling and epicardial fat accumulation, endothelial dysfunction, and coronary microvascular dysfunction...
March 15, 2024: ESC Heart Failure
https://read.qxmd.com/read/38380837/design-and-baseline-characteristics-of-salt-hf-trial-hypertonic-saline-therapy-in-ambulatory-heart-failure
#2
JOURNAL ARTICLE
M Cobo Marcos, J Comín-Colet, R de la Espriella, J Rubio Gracia, J L Morales-Rull, I Zegrí, P Llacer, P Diez-Villanueva, S Jiménez-Marrero, J de Juan Bagudá, C Ortiz Cortés, J Goirigolzarri-Artaza, J M García-Pinilla, E Barrios, S Del Prado Díaz, E Montero Hernández, M Sanchez-Marteles, J Nuñez
AIMS: Hypertonic saline solution (HSS) plus intravenous (IV) loop diuretic appears to enhance the diuretic response in patients hospitalized for heart failure (HF). The efficacy and safety of this therapy in the ambulatory setting have not been evaluated. We aimed to describe the design and baseline characteristics of the SALT-HF trial participants. METHODS AND RESULTS: 'Efficacy of Saline Hypertonic Therapy in Ambulatory Patients with HF' (SALT-HF) trial was a multicenter, double-blinded, and randomized study involving ambulatory patients who experienced worsening heart failure (WHF) without criteria for hospitalization...
February 21, 2024: ESC Heart Failure
https://read.qxmd.com/read/38438119/association-between-use-of-sodium-glucose-cotransporter-2-inhibitors-or-angiotensin-receptor-neprilysin-inhibitor-and-the-risk-of-atherosclerotic-cardiovascular-disease-with-coexisting-diabetes-and-heart-failure
#3
JOURNAL ARTICLE
Ya-Wen Lin, Chun-Hsiang Lin, Cheng-Li Lin, Che-Huei Lin, Ming-Hung Lin
PURPOSE: This study was to investigate the association between the use of Sodium-glucose Cotransporter-2 inhibitors (SGLT2i) or angiotensin receptor-neprilysin inhibitor (ARNI; ie, Sacubitril + valsartan, Product name ENTRESTO) and the risk of atherosclerotic cardiovascular disease (ASCVD) in patients with coexisting diabetes and heart failure. Specifically, the study compared outcomes between patients using SGLT2i or valsartan + sacubitril and those not using these medications...
2024: Journal of Cardiovascular Pharmacology and Therapeutics
https://read.qxmd.com/read/38419719/assessment-and-management-of-ischaemic-heart-disease-in-non-cardiac-surgery
#4
REVIEW
Holly Morgan, Saad M Ezad, Haseeb Rahman, Kalpa De Silva, Judith S L Partridge, Divaka Perera
In the setting of non-cardiac surgery, cardiac complications contribute to over a third of perioperative deaths. With over 230 million major surgeries performed annually, and an increasing prevalence of cardiovascular risk factors and ischaemic heart disease, the incidence of perioperative myocardial infarction is also rising. The recent European Society of Cardiology guidelines on cardiovascular risk in noncardiac surgery elevated practices aiming to identify those at most risk, including biomarker monitoring and stress testing...
2023: Heart International
https://read.qxmd.com/read/38222977/clinical-aspects-of-ischemia-with-no-obstructive-coronary-artery-disease-inoca
#5
JOURNAL ARTICLE
Alexander Polyak, Janet Wei, Martha Gulati, Noel Bairey Merz
Ischemia with no obstructive coronary arteries (INOCA) is defined as patients with evidence of myocardial ischemia without obstructive coronary artery disease. About 3-4 million people in the United States have INOCA, more commonly affecting women, and carries adverse morbidity, mortality, and relatively high healthcare costs. The pathophysiology of INOCA appears to be multi-factorial with a variety of contributing mechanisms. Diagnosis of INOCA is suggested by non-invasive or invasive testing consistent with myocardial ischemia...
January 2024: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38343041/vasospastic-angina-a-review-on-diagnostic-approach-and-management
#6
REVIEW
Kenny Jenkins, Graziella Pompei, Nandine Ganzorig, Sarah Brown, John Beltrame, Vijay Kunadian
Vasospastic angina (VSA) refers to chest pain experienced as a consequence of myocardial ischaemia caused by epicardial coronary spasm, a sudden narrowing of the vessels responsible for an inadequate supply of blood and oxygen. Coronary artery spasm is a heterogeneous phenomenon that can occur in patients with non-obstructive coronary arteries and obstructive coronary artery disease, with transient spasm causing chest pain and persistent spasm potentially leading to acute myocardial infarction (MI). VSA was originally described as Prinzmetal angina or variant angina, classically presenting at rest, unlike most cases of angina (though in some patients, vasospasm may be triggered by exertion, emotional, mental or physical stress), and associated with transient electrocardiographic changes (transient ST-segment elevation, depression and/or T-wave changes)...
2024: Therapeutic Advances in Cardiovascular Disease
https://read.qxmd.com/read/38342141/association-of-ldl-c-hdl-c-ratio-with-coronary-heart-disease-a-meta-analysis
#7
REVIEW
Siqi Hu, Hua Fan, Shenghui Zhang, Chen Chen, Yao You, Chunyi Wang, Jie Li, Lin Luo, Yongran Cheng, Mengyun Zhou, Xuezhi Zhao, Wen Wen, Tao Tan, Fangfang Xu, Xinyan Fu, Juan Chen, Xingwei Zhang, Mingwei Wang, Jiake Tang
BACKGROUND: Coronary heart disease (CHD) is a common heart disease and a leading cause of death in developed countries and some developing countries such as China. It is recognized as a multifactorial disease, with dyslipidemia being closely associated with the progression of coronary atherosclerosis. Numerous studies have confirmed the relationship between a single indicator of low-density lipoprotein cholesterol (LDL-C) or high-density lipoprotein cholesterol (HDL-C) and CHD. However, the association between LDL-C to HDL-C ratio (LHR) and CHD remains unclear...
February 9, 2024: Indian Heart Journal
https://read.qxmd.com/read/38320259/lipoprotein-a-association-with-residual-risk-what-has-inflammation-got-to-do-with-it
#8
JOURNAL ARTICLE
Zareen M Farukhi, Samia Mora
No abstract text is available yet for this article.
February 6, 2024: European Heart Journal
https://read.qxmd.com/read/38331813/cardiorenal-effectiveness-of-empagliflozin-vs-glucagon-like-peptide-1-receptor-agonists-final-year-results-from-the-emprise-study
#9
JOURNAL ARTICLE
Phyo T Htoo, Helen Tesfaye, Sebastian Schneeweiss, Deborah J Wexler, Brendan M Everett, Robert J Glynn, Niklas Schmedt, Lisette Koeneman, Anouk Déruaz-Luyet, Julie M Paik, Elisabetta Patorno
BACKGROUND: No randomized clinical trials have directly compared the cardiorenal effectiveness of empagliflozin and GLP-1RA agents with demonstrated cardioprotective effects in patients with a broad spectrum of cardiovascular risk. We reported the final-year results of the EMPRISE study, a monitoring program designed to evaluate the cardiorenal effectiveness of empagliflozin across broad patient subgroups. METHODS: We identified patients ≥ 18 years old with type 2 diabetes who initiated empagliflozin or GLP-1RA from 2014 to 2019 using US Medicare and commercial claims databases...
February 8, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38344488/the-efficacy-of-antihypertensive-drugs-in-lowering-blood-pressure-and-cardiovascular-events-in-the-elderly-population-a-systematic-review-and-meta-analysis
#10
REVIEW
Raheel Chaudhry, Yusuf A Siddique, Ahmad Sebai, Mustafa M Moazam, Ghazala S Virk, Yonas Tamene, Mohamed Hassouba
Cardiovascular disease is the leading cause of mortality and morbidity worldwide. One of the main risk factors for cardiovascular events is hypertension. The use of antihypertensive drugs can protect against these events. It occurs directly through the control of hypertension and indirectly through other cardiovascular effects. This meta-analysis and systematic review aimed to assess the impact of various antihypertensive medications (ACE inhibitors, beta-blockers, calcium channel blockers, diuretics, etc.) on blood pressure and various cardiovascular outcomes...
January 2024: Curēus
https://read.qxmd.com/read/38276131/post-capillary-pulmonary-hypertension-clinical-review
#11
REVIEW
Joshua M Riley, James J Fradin, Douglas H Russ, Eric D Warner, Yevgeniy Brailovsky, Indranee Rajapreyar
Pulmonary hypertension (PH) caused by left heart disease, also known as post-capillary PH, is the most common etiology of PH. Left heart disease due to systolic dysfunction or heart failure with preserved ejection fraction, valvular heart disease, and left atrial myopathy due to atrial fibrillation are causes of post-capillary PH. Elevated left-sided filling pressures cause pulmonary venous congestion due to backward transmission of pressures and post-capillary PH. In advanced left-sided heart disease or valvular heart disease, chronic uncontrolled venous congestion may lead to remodeling of the pulmonary arterial system, causing combined pre-capillary and post-capillary PH...
January 22, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38253300/bicuspid-aortic-valve-the-most-frequent-and-not-so-benign-congenital-heart-disease
#12
REVIEW
Gaetano Thiene, Stefania Rizzo, Cristina Basso
Bicuspid aortic valve (BAV) is the most frequent congenital heart disease, with an incidence of approximately 1%. It can be silent and associated with normal valve function. However, a series of complications, even catastrophic, may occur with time: valve incompetence, valve stenosis by dystrophic calcification, infective endocarditis, progressive dilatation of the ascending aorta, aortic dissection, sudden death. The problem of BAV is not just about the number of semilunar cusps, but also the aortic wall. Severe non inflammatory degenerative changes (elastic fiber fragmentation, smooth muscle cells death, mucoid extracellular matrix accumulation=MEMA) is observed in the aortic wall of BAV patients, with intrinsic weakness accounting for progressive aneurysmal dilatation of the ascending aorta, valve incompetence and wall dissection...
January 20, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://read.qxmd.com/read/38229816/updates-in-the-management-of-coronary-artery-disease-a-review-article
#13
REVIEW
Archit Bansal, Kishore Hiwale
Coronary artery disease (CAD) remains a significant health challenge, imposing substantial burdens on individuals and healthcare systems worldwide. CAD's impact stems from artery narrowing and blockage, leading to severe complications like heart attacks and heart failure. Collaborative efforts by researchers, professionals, and governments have fostered advancements in comprehending and managing this cardiovascular ailment. Evolving CAD management embraces modern diagnostics, cutting-edge pharmaceuticals, invasive procedures, lifestyle modifications, and cardiac rehabilitation...
December 2023: Curēus
https://read.qxmd.com/read/38224446/antiarrhythmic-treatment-in-heart-failure
#14
REVIEW
Hilke Könemann, Sati Güler-Eren, Christian Ellermann, Gerrit Frommeyer, Lars Eckardt
PURPOSE OF REVIEW: Arrhythmias are common in patients with heart failure (HF) and are associated with a significant risk of mortality and morbidity. Optimal antiarrhythmic treatment is therefore essential. Here, we review current approaches to antiarrhythmic treatment in patients with HF. RECENT FINDINGS: In atrial fibrillation, rhythm control and ventricular rate control are accepted therapeutic strategies. In recent years, clinical trials have demonstrated a prognostic benefit of early rhythm control strategies and AF catheter ablation, especially in patients with HF with reduced ejection fraction...
January 15, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38233270/effects-of-childhood-obesity-on-heart-failure-and-its-associated-risk-factors-in-the-european-population-a-mendelian-randomization-study
#15
JOURNAL ARTICLE
Renjing Kong, Shuang Li
BACKGROUND AND AIMS: Observational studies have shown that obesity considerably affects the cardiovascular system. Thus we conducted this Mendelian randomization (MR) analysis to evaluate the causal effect of childhood obesity on heart failure (HF) and its risk factors. METHODS AND RESULTS: We obtained genetic instruments from genome-wide association studies (GWAS) that investigated childhood obesity, HF, type 2 diabetes mellitus (T2DM), atrial fibrillation (AF), coronary artery disease (CAD), myocardial infarction (MI), chronic kidney disease (CKD), valvular heart disease, myocarditis, hypertrophic cardiomyopathy, and hyperthyroidism...
December 4, 2023: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://read.qxmd.com/read/38239526/the-trend-of-arrhythmias-in-patients-with-covid-19-a-complication-or-late-manifestation
#16
REVIEW
Yusuf A Siddique, Raheel Chaudhry, Muhammad Ahmad, Ahmad Sebai, Lubhani Sharma, Mohamed Hassouba, Ghazala S Virk
Patients diagnosed with coronavirus disease (CVD) who experience cardiovascular complications or have pre-existing cardiovascular disease are at an increased risk of death. The primary heart-related consequences associated with COVID-19 encompass venous thromboembolism, shock, heart failure, arrhythmias, myocarditis, acute myocardial infarction, and acute cardiac damage. The coronavirus has the potential to induce cardiovascular complications or exacerbate pre-existing CVD through various mechanisms. These mechanisms include dysregulation of the renin-angiotensin-aldosterone system; direct viral toxicity; damage to endothelial cells; formation of blood clots and subsequent inflammation, a phenomenon known as thromboinflammation; an excessive immune response known as cytokine storm; and an imbalance between the demand and supply of oxygen in the body...
December 2023: Curēus
https://read.qxmd.com/read/38195096/the-10-commandments-for-the-2023-esc-guidelines-for-the-management-of-cardiovascular-disease-in-patients-with-diabetes
#17
JOURNAL ARTICLE
Katharina Schütt, Massimo Federici, Marlo Verket, Nikolaus Marx, Dirk Müller-Wieland
No abstract text is available yet for this article.
January 9, 2024: European Heart Journal
https://read.qxmd.com/read/38199714/hyperuricemia-and-gout-reduction-by%C3%A2-sglt2-inhibitors-in-diabetes-and-heart%C3%A2-failure-jacc%C3%A2-review-topic-of-the-week
#18
REVIEW
Milton Packer
Gout is characterized by increased production of purines (through the pentose phosphate pathway), which is coupled with reduced renal or intestinal excretion of urate. Concurrent upregulation of nutrient surplus signaling (mammalian target of rapamycin and hypoxia-inducible factor-1a) and downregulation of nutrient deprivation signaling (sirtuin-1 and adenosine monophosphate-activated protein kinase) redirects glucose toward anabolic pathways (rather than adenosine triphosphate production), thus promoting heightened oxidative stress and cardiomyocyte and proximal tubular dysfunction, leading to cardiomyopathy and kidney disease...
January 16, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38150260/optimization-of-evidence-based-heart-failure-medications-after-an-acute-heart-failure-admission-a-secondary-analysis-of-the-strong-hf-randomized-clinical-trial
#19
JOURNAL ARTICLE
Gad Cotter, Benjamin Deniau, Beth Davison, Christopher Edwards, Marianna Adamo, Mattia Arrigo, Marianela Barros, Jan Biegus, Jelena Celutkiene, Kamile Cerlinskaite-Bajore, Ovidiu Chioncel, Alain Cohen-Solal, Albertino Damasceno, Rafael Diaz, Gerasimos Filippatos, Etienne Gayat, Antoine Kimmoun, Carolyn S P Lam, Marco Metra, Maria Novosadova, Peter S Pang, Matteo Pagnesi, Piotr Ponikowski, Hadiza Saidu, Karen Sliwa, Koji Takagi, Jozine M Ter Maaten, Daniela Tomasoni, Adriaan Voors, Alexandre Mebazaa
IMPORTANCE: The Safety, Tolerability, and Efficacy of Rapid Optimization, Helped by N-Terminal Pro-Brain Natriuretic Peptide Testing of Heart Failure Therapies (STRONG-HF) trial strived for rapid uptitration aiming to reach 100% optimal doses of guideline-directed medical therapy (GDMT) within 2 weeks after discharge from an acute heart failure (AHF) admission. OBJECTIVE: To assess the association between degree of GDMT doses achieved in high-intensity care and outcomes...
December 27, 2023: JAMA Cardiology
https://read.qxmd.com/read/38195064/how-to-diagnose-and-treat-venous-congestion-in-heart-failure
#20
JOURNAL ARTICLE
Pierpaolo Pellicori, David Hunter, Htet Htet Ei Khin, John G F Cleland
No abstract text is available yet for this article.
January 9, 2024: European Heart Journal
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