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CKD Progression

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335 papers 100 to 500 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Neil R Powe
No abstract text is available yet for this article.
March 12, 2019: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Hyung Woo Kim, Jung Tak Park, Tae-Hyun Yoo, Joongyub Lee, Wookyung Chung, Kyu-Beck Lee, Dong-Wan Chae, Curie Ahn, Shin-Wook Kang, Kyu Hun Choi, Seung Hyeok Han
BACKGROUND AND OBJECTIVES: Data on whether low or high urinary potassium excretion is associated with poor kidney outcome have been conflicting. The aim of this study was to clarify the association between urinary potassium excretion and CKD progression. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We investigated the relationship between lower urinary potassium excretion and CKD progression and compared three urinary potassium indices among 1821 patients from the Korean Cohort Study for Outcome in Patients with CKD...
February 14, 2019: Clinical Journal of the American Society of Nephrology: CJASN
Yoshikazu Nemoto, Takanori Kumagai, Kenichi Ishizawa, Yutaka Miura, Takeshi Shiraishi, Chikayuki Morimoto, Kazuhiro Sakai, Hiroki Omizo, Osamu Yamazaki, Yoshifuru Tamura, Yoshihide Fujigaki, Hiroshi Kawachi, Makoto Kuro-O, Shunya Uchida, Shigeru Shibata
Recent clinical studies indicate that the disturbed phosphate metabolism in chronic kidney disease (CKD) may facilitate kidney injury; nonetheless, the causal role of phosphate in CKD progression remains to be elucidated. Here, we show that intestinal phosphate binding by sucroferric oxyhydroxide (SF) ameliorates renal injury in the rat remnant kidney model. Sprague-Dawley rats received 5/6 nephrectomy (RK) and had a normal chow or the same diet containing SF (RK + SF). RK rats showed increased plasma FGF23 and phosphate levels, which were suppressed by SF administration...
February 11, 2019: Scientific Reports
Sergio de Frutos, Alicia Luengo, Andrea García Jérez, Marco Hatem Vaquero, Mercedes Griera, Francisco O'Valle, Manuel Rodríguez-Puyol, Diego Rodríguez-Puyol, Laura Calleros
Kidney fibrosis is one of the main pathological findings of progressive chronic kidney disease (CKD) although the pathogenesis of renal scar formation remains incompletely explained. Integrin-linked kinase (ILK), a major scaffold protein between the extracellular matrix (ECM) and intracellular signaling pathways, is involved in several pathophysiological processes during renal damage. However, ILK contribution in the CKD progress remains to be fully elucidated. In the present work, we studied 1) the renal functional and structural consequences of CKD genesis and progression when ILK is depleted and 2) the potential of ILK depletion as a therapeutic approach to delay CKD progression...
February 3, 2019: Biochimica et biophysica acta. Molecular basis of disease
Toshihiro Sugiura, Fuyuko Akagaki, Yoshito Yamaguchi, Aya Nakamori
Background Renal arteriolosclerosis is a risk factor for acute reductions in the glomerular filtration rate (GFR) when renin-angiotensin system (RAS) inhibitors are administered. Renal arteriolosclerosis can be detected by an increase in the resistive index (RI) on Doppler ultrasonography. The purpose of the present study is to determine whether or not the RI can predict acute GFR reductions following RAS blockade in chronic kidney disease (CKD). Methods We surveyed all CKD patients who were hospitalized in Otemae Hospital from January 2008 to December 2017...
January 10, 2019: Internal Medicine
Ching-Wei Tsai, Han-Chun Huang, Ni Tien, Chih-Wei Chung, Hsien-Tsai Chiu, Hung-Chieh Yeh, Chin-Chi Kuo
BACKGROUND: The clinical importance of random urine creatinine concentration in CKD population remains undetermined. Earlier studies found that lower 24-h urine creatinine excretion was associated with the risk of ESRD and all-cause mortality among CKD patients. METHODS: We modeled the longitudinal trajectories of serial random urine creatinine among 4689 CKD patients enrolled in a national registry-based pre-ESRD program between 2003 and 2015 at a tertiary medical center...
February 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Mei-Yueh Lee, Jiun-Chi Huang, Szu-Chia Chen, Hsin-Ying Clair Chiou, Pei-Yu Wu
Little is known about the predictive value of glycosylated hemoglobin (HbA1C ) variability in patients with advanced chronic kidney disease (CKD). The aim of this study was to investigate whether HbA1C variability is associated with progression to end-stage renal disease in diabetic patients with stages 3⁻5 CKD, and whether different stages of CKD affect these associations. Three hundred and eighty-eight patients with diabetes and stages 3⁻5 CKD were enrolled in this longitudinal study. Intra-individual HbA1C variability was defined as the standard deviation (SD) of HbA1C , and the renal endpoint was defined as commencing dialysis...
December 18, 2018: International Journal of Molecular Sciences
Piotr Kuczera, Katarzyna Kwiecień, Marcin Adamczak, Teresa Bączkowska, Jolanta Gozdowska, Katarzyna Madziarska, Hanna Augustyniak-Bartosik, Marian Klinger, Magdalena Durlik, Eberhard Ritz, Andrzej Wiecek
BACKGROUND/AIMS: Arterial hypertension is one of the leading factors aggravating the course of chronic kidney disease (CKD). It seems that the novel parameters used in the assessment of the blood pressure (BP) load (i.e. central blood pressure, nighttime blood pressure) may be more precise in predicting the cardiovascular risk and the progression of CKD in comparison with the traditional peripheral blood pressure measurements in the office conditions. The aim of the study was to assess the impact of the central, or nighttime blood pressure on the progression of CKD in patients with mild or no-proteinuria (autosomal, dominant polycystic kidney disease or IgA nephropathy)...
2018: Kidney & Blood Pressure Research
Simone Vettoretti, Lara Caldiroli, Francesca Zanoni, Valeria Azzini, Anna Villarini, Roberto Meazza, Piergiorgio Messa
BACKGROUND/AIMS: In patients with chronic kidney disease (CKD) strict blood pressure (BP) control is reno-protective. However, renal benefits from BP control might depend also on the etiology of CKD. We investigated if maintenance of BP at target is equally effective in subjects with hypertensive nephropathy (HN+) and in those with other nephropathies (HN-). METHODS: We evaluated 148 patients with CKD (stages 3-5) in two visits at least 12 months apart. BP was measured both as office BP and 24h ambulatory blood pressure (ABP)...
2018: Kidney & Blood Pressure Research
Lesley A Inker, Hiddo L Heerspink
No abstract text is available yet for this article.
December 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jeroen P Kooman, Len A Usvyat, Marijke J E Dekker, Dugan W Maddux, Jochen G Raimann, Frank M van der Sande, Xiaoling Ye, Yuedong Wang, Peter Kotanko
Patients with end-stage renal disease (ESRD) experience unique patterns in their lifetime, such as the start of dialysis and renal transplantation. In addition, there is also an intricate link between ESRD and biological time patterns. In terms of cyclic patterns, the circadian blood pressure (BP) rhythm can be flattened, contributing to allostatic load, whereas the circadian temperature rhythm is related to the decline in BP during hemodialysis (HD). Seasonal variations in BP and interdialytic-weight gain have been observed in ESRD patients in addition to a profound relative increase in mortality during the winter period...
November 16, 2018: Blood Purification
Pietro E Cippà, Bo Sun, Jing Liu, Liang Chen, Maarten Naesens, Andrew P McMahon
BACKGROUND: The molecular understanding of the progression from acute to chronic organ injury is limited. Ischemia/reperfusion injury (IRI) triggered during kidney transplantation can contribute to progressive allograft dysfunction. METHODS: Protocol biopsies (n = 163) were obtained from 42 kidney allografts at 4 time points after transplantation. RNA sequencing-mediated (RNA-seq-mediated) transcriptional profiling and machine learning computational approaches were employed to analyze the molecular responses to IRI and to identify shared and divergent transcriptional trajectories associated with distinct clinical outcomes...
November 15, 2018: JCI Insight
Carl P Walther, Maulin Shah, Sankar D Navaneethan
No abstract text is available yet for this article.
November 10, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Kei Sugiyama, Tsutomu Inoue, Eito Kozawa, Masahiro Ishikawa, Akira Shimada, Naoki Kobayashi, Junji Tanaka, Hirokazu Okada
Background: Although chronic hypoxia and fibrosis may be a key to the progression of chronic kidney disease (CKD), a noninvasive means of measuring these variables is not yet available. Here, using blood oxygen level-dependent (BOLD) and diffusion-weighted (DW) magnetic resonance imaging (MRI), we assessed changes in renal tissue oxygenation and fibrosis, respectively, and evaluated their correlation with prognosis for renal function. Methods: The study was conducted under a single-center, longitudinal, retrospective observational design...
November 12, 2018: Nephrology, Dialysis, Transplantation
Bingjuan Yan, Xiaole Su, Boyang Xu, Xi Qiao, Lihua Wang
BACKGROUND: Dietary protein restriction has long been thought to play an important role in the progression of chronic kidney disease (CKD); however, the effect of dietary protein on the rate of decline in kidney function remains controversial. OBJECTIVE: We undertook a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the influence of protein restriction on chronic kidney disease. METHOD: Ovid MEDLINE (from 1946 to March 5, 2016), EMBASE (from 1966 to March 5, 2016), and the Cochrane Library (Inception to March 5, 2016) were searched to identify RCTs comparing different levels of protein intake for at least 24 weeks in adult patients with CKD...
2018: PloS One
Radmila Žeravica, Branislava Ilinčić, Velibor Čabarkapa, Isidora Radosavkić, Jelena Samac, Katarina Nikoletić, Zoran Stošić
AIM: Elevated fractional excretion of magnesium (FEMg) is a noninvasive biomarker of kidney damage, but its association with kidney functional parameters in nondiabetic chronic kidney disease (CKD) patients has not been sufficiently explored thus far. METHODS: We enrolled 111 adult patients with nondiabetic CKD and 30 controls. To precisely investigate kidney function, the following parameters were assessed measured glomerular filtration rate (mGFR), effective renal plasma flow (ERPF), Cystatin C, albuminuria, and fractional excretion of magnesium (FEMg)...
May 1, 2018: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
Bjørn O Eriksen, Silje Småbrekke, Trond G Jenssen, Ulla D Mathisen, Jon V Norvik, Jørgen Schei, Henrik Schirmer, Marit D Solbu, Vidar T N Stefansson, Toralf Melsom
The decline in glomerular filtration rate (GFR) associated with aging is one of the most important predisposing causes of kidney failure in old age. Identifying persons at risk for accelerated GFR decline is an essential first step in the development of preventive measures to preserve kidney function in the elderly. Heart rate (HR) has not yet been studied as a risk factor for GFR decline in the general population. In the RENIS-T6 (Renal Iohexol-Clearance Survey in Tromsø 6), we measured baseline ambulatory HR and GFR as iohexol clearance in a representative, middle-aged cohort of 1627 persons without self-reported diabetes mellitus, cardiovascular disease, or kidney disease...
September 2018: Hypertension
Shinji Machida, Yugo Shibagaki, Tsutomu Sakurada
BACKGROUND: Chronic kidney disease (CKD) is a significant health problem in Japan, and prevention programs to slow disease progression are necessary. In this study, we evaluated the effectiveness of a 1-week inpatient education program, delivered during the predialysis stage of CKD, in slowing the deterioration in renal function over the subsequent 2 years, and identified factors influencing the program's effectiveness. METHODS: We retrospectively evaluated the estimated glomerular filtration rate (eGFR) of 105 consecutive patients who completed the program, at the following time points: 6 months prior to program initiation, at program initiation and, at 6, 12, 18, and 24 months after the program...
October 19, 2018: Clinical and Experimental Nephrology
Yoshihiko Imamura, Yasunori Takahashi, Toshihide Hayashi, Masateru Iwamoto, Rie Nakamura, Mikiko Goto, Kazuyo Takeba, Makoto Shinohara, Shun Kubo, Nobuhiko Joki
BACKGROUND: Comprehensive education about lifestyle, nutrition, medications and other types of treatment is important to prevent renal dysfunction in patients with chronic kidney disease (CKD). However, the effectiveness of multidisciplinary care on CKD progression has not been evaluated in detail. We aimed to determine whether multidisciplinary care at our hospital could help prevent worsening renal function associated with CKD. METHODS: A total of 150 pre-dialysis CKD outpatients accompanied (n = 68) or not (n = 82) with diabetes mellitus (DM) were enrolled into this study...
October 19, 2018: Clinical and Experimental Nephrology
Gesine F C Weckmann, Sylvia Stracke, Annekathrin Haase, Jacob Spallek, Fabian Ludwig, Aniela Angelow, Jetske M Emmelkamp, Maria Mahner, Jean-François Chenot
BACKGROUND: Chronic kidney disease (CKD) is age-dependent and has a high prevalence in the general population. Most patients are managed in ambulatory care. This systematic review provides an updated overview of quality and content of international clinical practice guidelines for diagnosis and management of non-dialysis CKD relevant to patients in ambulatory care. METHODS: We identified guidelines published from 2012-to March 2018 in guideline portals, databases and by manual search...
October 11, 2018: BMC Nephrology
2018-10-15 06:35:50
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