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Barrett's Esophagus

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6 papers 0 to 25 followers
By Faye Kehler Family Physician and GP Anesthetist since 1987 interested in all aspects of Medicine
F Hvid-Jensen, L Pedersen, P Funch-Jensen, A M Drewes
BACKGROUND: Proton pump inhibitors (PPI) may potentially modify and decrease the risk for development of oesophageal adenocarcinoma in Barrett's oesophagus (BO). AIM: To investigate if the intensity and adherence of PPI use among all patients with BO in Denmark affected the risk of oesophageal adenocarcinoma. METHODS: We performed a nationwide case-control study in Denmark among 9883 patients with a new diagnosis of BO. All incident oesophageal adenocarcinomas and high-grade dysplasias were identified, and risk ratios were estimated on the basis of prior use of PPIs...
May 2014: Alimentary Pharmacology & Therapeutics
Daniel E Freedberg, Lawrence S Kim, Yu-Xiao Yang
BACKGROUND & AIMS: The purpose of this review is to evaluate the risks associated with long-term use of proton pump inhibitors (PPIs), focusing on long-term use of PPIs for three common indications: gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), and non-steroidal anti-inflammatory drug (NSAID) bleeding prophylaxis. METHODS: The recommendations outlined in this review are based on expert opinion and on relevant publications from PubMed, EMbase, and the Cochrane library (through July 2016)...
March 2017: Gastroenterology
Helen G Coleman, Shivaram K Bhat, Liam J Murray, Damian T McManus, Orla M O'Neill, Anna T Gavin, Brian T Johnston
OBJECTIVES: Risk stratification of Barrett's esophagus (BE) patients based on clinical and endoscopic features may help to optimize surveillance practice for esophageal adenocarcinoma (EAC) development. The aim of this study was to investigate patient symptoms and endoscopic features at index endoscopy and risk of neoplastic progression in a large population-based cohort of BE patients. METHODS: A retrospective review of hospital records relating to incident BE diagnosis was conducted in a subset of patients with specialized intestinal metaplasia from the Northern Ireland BE register...
April 2014: American Journal of Gastroenterology
Srinivas Gaddam, Mandeep Singh, Gokulakrishnan Balasubramanian, Prashanthi Thota, Neil Gupta, Sachin Wani, April D Higbee, Sharad C Mathur, John D Horwhat, Amit Rastogi, Patrick E Young, Brooks D Cash, Ajay Bansal, John J Vargo, Gary W Falk, David A Lieberman, Richard E Sampliner, Prateek Sharma
BACKGROUND & AIMS: Recent population-based studies have shown a low risk of esophageal adenocarcinoma (EAC) in patients with nondysplastic Barrett's esophagus (NDBE). We evaluated whether persistence of NDBE over multiple consecutive surveillance endoscopic examinations could be used in risk stratification of patients with Barrett's esophagus (BE). METHODS: We performed a multicenter outcomes study of a large cohort of patients with BE. Based on the number of consecutive surveillance endoscopies showing NDBE, we identified 5 groups of patients...
September 2013: Gastroenterology
Douglas A Corley, Kunal Mehtani, Charles Quesenberry, Wei Zhao, Jolanda de Boer, Noel S Weiss
BACKGROUND & AIMS: Although patients with Barrett's esophagus commonly undergo endoscopic surveillance, its effectiveness in reducing mortality from esophageal/gastroesophageal junction adenocarcinomas has not been evaluated rigorously. METHODS: We performed a case-control study in a community-based setting. Among 8272 members with Barrett's esophagus, we identified 351 esophageal adenocarcinoma: 70 in persons who had a prior diagnosis of Barrett's esophagus (who were eligible for surveillance); 51 of these patients died, 38 as a result of the cancers (cases)...
August 2013: Gastroenterology
Massimo Rugge, Giovanni Zaninotto, Paola Parente, Lisa Zanatta, Francesco Cavallin, Bastianello Germanà, Ettore Macrì, Ermenegildo Galliani, Paolo Iuzzolino, Francesco Ferrara, Renato Marin, Emiliano Nisi, Gaetano Iaderosa, Michele Deboni, Angelo Bellumat, Flavio Valiante, Georgeta Florea, Duilio Della Libera, Marco Benini, Laura Bortesi, Alberto Meggio, Maria G Zorzi, Giovanni Depretis, Gianni Miori, Luca Morelli, Giovanni Cataudella, Emanuele S G d'Amore, Emanuele Dʼamore, Ilaria Franceschetti, Loredana Bozzola, Elisabetta Paternello, Cristina Antonini, Francesco Di Mario, Nadia Dal Bò, Alberto Furlanetto, Lorenzo Norberto, Lino Polese, Silvia Iommarini, Fabio Farinati, Giorgio Battaglia, Giorgio Diamantis, Stefano Realdon, Ennio Guido, Gaetano Mastropaolo, Daniele Canova, Antonello Guerini, Marilisa Franceschi, Maurizio Zirillo
OBJECTIVE: To establish the incidence and risk factors for progression to high-grade intraepithelial neoplasia (HG-IEN) or Barrett's esophageal adenocarcinoma (BAc) in a prospective cohort of patients with esophageal intestinal metaplasia [(BE)]. BACKGROUND: BE is associated with an increased risk of BAc unless cases are detected early by surveillance. No consistent data are available on the prevalence of BE-related cancer, the ideal surveillance schedule, or the risk factors for cancer...
November 2012: Annals of Surgery
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