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Biopsy of the Kidney and Renal Allograft

https://read.qxmd.com/read/37260998/-ex-vivo-confocal-microscopy-detects-basic-patterns-of-acute-and-chronic-lesions-using-fresh-kidney-samples
#21
JOURNAL ARTICLE
Jesús Z Villarreal, Javiera Pérez-Anker, Susana Puig, Marc Xipell, Gerard Espinosa, Esther Barnadas, Ana B Larque, J Malvehy, Ricard Cervera, Arturo Pereira, Antonio Martinez-Pozo, Luis F Quintana, Adriana García-Herrera
BACKGROUND: Ex vivo confocal microscopy is a real-time technique that provides high-resolution images of fresh, non-fixed tissues, with an optical resolution comparable to conventional pathology. The objective of this study was to investigate the feasibility of using ex vivo confocal microscopy in fusion mode (FuCM) and the haematoxylin and eosin (H&E)-like digital staining that results for the analysis of basic patterns of lesion in nephropathology. METHODS: Forty-eight renal samples were scanned in a fourth-generation ex vivo confocal microscopy device...
June 2023: Clinical Kidney Journal
https://read.qxmd.com/read/37027795/toward-real-world-computational-nephropathology
#22
JOURNAL ARTICLE
Rodrigo T Calumby, Angelo A Duarte, Michele F Angelo, Emanuele Santos, Pinaki Sarder, Washington L C Dos-Santos, Luciano R Oliveira
No abstract text is available yet for this article.
June 1, 2023: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/36967883/establishing-an-effective-clinical-data-collecting-tool-for-optimal-evaluation-of-native-and-allograft-renal-biopsies
#23
JOURNAL ARTICLE
Shifaa' Al Qa'qa', Rehab Al-Fatani, Sonia Rodriguez-Ramirez, Prakash Gudsoorkar, Laurette Geldenhuys, Carmen Avila-Casado
INTRODUCTION: Percutaneous kidney biopsy is the gold standard method to reach a precise diagnosis in most medical kidney diseases, which positively impacts patient care by personalizing the treatment. Accurate diagnosis in the pathology report for medical kidney diseases requires clinicopathological correlation, and clinical data is not always reachable to the nephropathologist. This study aimed to create a standardized, paperless requisition form compatible with medical renal biopsies...
March 2023: Heliyon
https://read.qxmd.com/read/36874304/protocol-biopsy-after-kidney-transplant-clinical-application-and-efficacy-to-detect-allograft-rejection
#24
JOURNAL ARTICLE
Mahmoudreza Moein, Sarah Papa, Noelle Ortiz, Reza Saidi
Background Kidney transplant rejection is a major cause of graft dysfunction and failure. In recent years, there has been increased interest in renal allograft protocol biopsies to allow earlier detection of acute or chronic graft dysfunction or rejection to improve long-term graft survival and reduce graft failure. This study aimed to determine if renal allograft protocol biopsies performed within the first 12 months after transplantation help detect subclinical graft dysfunction or rejection. Methods We performed a retrospective analysis utilizing SUNY Upstate University Hospital data from January 2016 to March 2022 to assess transplant outcomes and biopsies...
February 2023: Curēus
https://read.qxmd.com/read/36815108/high-macrophage-densities-in-native-kidney-biopsies-correlate-with-renal-dysfunction-and-promote-esrd
#25
JOURNAL ARTICLE
Maren B Pfenning, Jessica Schmitz, Irina Scheffner, Kevin Schulte, Abedalrazag Khalifa, Hossein Tezval, Alexander Weidemann, Anke Kulschewski, Ulrich Kunzendorf, Sebastian Dietrich, Hermann Haller, Jan T Kielstein, Wilfried Gwinner, Jan H Bräsen
INTRODUCTION: Macrophages and monocytes are main players in innate immunity. The relevance of mononuclear phagocyte infiltrates on clinical outcomes remains to be determined in native kidney diseases. METHODS: Our cross-sectional study included 324 patients with diagnostic renal biopsies comprising 17 disease entities and normal renal tissues for comparison. All samples were stained for CD68+ macrophages. Selected groups were further subtyped for CD14+ monocytes and CD163+ alternatively activated macrophages...
February 2023: KI Reports
https://read.qxmd.com/read/36723289/a-simple-molecular-tool-for-the-assessment-of-kidney-transplant-biopsies
#26
JOURNAL ARTICLE
Tristan de Nattes, Jack Beadle, Frederic Toulza, Edvin Candon, Philippe Ruminy, Arnaud François, Dominique Bertrand, Dominique Guerrot, Fanny Drieux, Candice Roufosse, Sophie Candon
BACKGROUND: The Banff Classification for Allograft Pathology recommendations for the diagnosis of kidney transplant rejection includes molecular assessment of the transplant biopsy. However, implementation of molecular tools in clinical practice is still limited, partly due to the required expertise and financial investment. The reverse transcriptase multiplex ligation-dependent probe amplification (RT-MLPA) assay is a simple, rapid, and inexpensive assay that permits simultaneous evaluation of a restricted gene panel using paraffin-embedded tissue blocks...
April 1, 2023: Clinical Journal of the American Society of Nephrology: CJASN
https://read.qxmd.com/read/36695677/impact-of-donor-kidney-biopsy-on-kidney-yield-and-posttransplant-outcomes
#27
JOURNAL ARTICLE
Connie J Wang, James B Wetmore, Andrew Wey, Jonathan Miller, Jon J Snyder, Ajay K Israni
Procurement biopsy is performed to determine kidney quality, but evidence supporting such association is poor. We investigated the impact of glomerulosclerosis percentage (GS%) on kidney yield and patient outcomes. Information on deceased kidney donors from July 1, 2017, to June 30, 2019, was collected. Association between GS% and kidney yield (number of kidneys procured per donor) and posttransplant graft and patient outcomes were studied. Maximal GS% and minimal GS% were calculated to determine the relationship between GS% and kidney yield; minimal GS% only for correlation with posttransplant outcomes...
January 2, 2023: American Journal of Transplantation
https://read.qxmd.com/read/36575574/relating-molecular-t-cell-mediated-rejection-activity-in-kidney-transplant-biopsies-to-time-and-to-histologic-tubulitis-and-atrophy-fibrosis
#28
JOURNAL ARTICLE
Katelynn S Madill-Thomsen, Georg A Böhmig, Jonathan Bromberg, Gunilla Einecke, Farsad Eskandary, Gaurav Gupta, Marek Myslak, Ondrej Viklicky, Agnieszka Perkowska-Ptasinska, Kim Solez, Philip F Halloran
BACKGROUND: We studied the variation in molecular T cell-mediated rejection (TCMR) activity in kidney transplant indication biopsies and its relationship with histologic lesions (particularly tubulitis and atrophy-fibrosis) and time posttransplant. METHODS: We examined 175 kidney transplant biopsies with molecular TCMR as defined by archetypal analysis in the INTERCOMEX study (ClinicalTrials.gov #NCT01299168). TCMR activity was defined by a molecular classifier...
December 28, 2022: Transplantation
https://read.qxmd.com/read/36529122/renal-histology-in-ckd-stages-match-or-mismatch-with-glomerular-filtration-rate
#29
REVIEW
Francesco Trevisani, Matteo Floris, Alessandra Cinque, Arianna Bettiga, Giacomo Dell'Antonio
A reliable assessment of renal function is of paramount importance in several clinical assets in order to tailor a personalized medical approach. CKD classification system, created in 2002 by the National Kidney Foundation-sponsored Kidney Disease Outcomes Quality Initiative and then implemented in the following years by the K-DIGO guidelines, offered clinicians a new strategy to better identify nephrological patients at low or high risk to develop renal insufficiency, in order to avoid the progression to end-stage renal disease...
2023: Nephron
https://read.qxmd.com/read/36396330/changes-in-glomerular-volume-sclerosis-and-ischemia-at-5-years-after-kidney-transplantation-incidence-and-correlation-with-late-graft-failure
#30
JOURNAL ARTICLE
Aleksandar Denic, Marija Bogojevic, Rashmi Subramani, Walter D Park, Byron H Smith, Mariam P Alexander, Joseph P Grande, Aleksandra Kukla, Carrie A Schinstock, Andrew J Bentall, Andrew D Rule, Mark D Stegall
SIGNIFICANCE STATEMENT: Glomerular volume, ischemic glomeruli, and global glomerulosclerosis are not consistently assessed on kidney transplant biopsies. The authors evaluated morphometric measures of glomerular volume, the percentage of global glomerulosclerosis, and the percentage of ischemic glomeruli and assessed changes in these measures over time to determine whether such changes predict late allograft failure. All three features increased from transplant to five-year biopsy. Kidneys with smaller glomeruli at 5 years had more global glomerulosclerosis and a higher percentage of ischemic-appearing glomeruli...
February 1, 2023: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/36351761/artificial-intelligence-you-can-trust-what-matters-beyond-performance-when-applying-artificial-intelligence-to-renal-histopathology
#31
REVIEW
John O O Ayorinde, Federica Citterio, Matteo Landrò, Elia Peruzzo, Tuba Islam, Simon Tilley, Geoffrey Taylor, Victoria Bardsley, Pietro Liò, Alex Samoshkin, Gavin J Pettigrew
Although still in its infancy, artificial intelligence (AI) analysis of kidney biopsy images is anticipated to become an integral aspect of renal histopathology. As these systems are developed, the focus will understandably be on developing ever more accurate models, but successful translation to the clinic will also depend upon other characteristics of the system.In the extreme, deployment of highly performant but "black box" AI is fraught with risk, and high-profile errors could damage future trust in the technology...
December 2022: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/36328815/experience-and-utility-of-the-protocol-kidney-biopsy-in-the-first-year-of-kidney-transplantation
#32
JOURNAL ARTICLE
C A Santana Quintana, R Gallego Samper, R Santana Estupiñán, S Aladro Escribano, D Medina García, Y Daruiz D Orazio, J C Quevedo Reina, F González Cabrera, N Vega Díaz, P Pérez Borges
BACKGROUND: Protocol kidney biopsy (PKB) in kidney transplant is a useful tool for graft monitoring because the subclinical detection of histologic lesions helps to modulate immunosuppression. We analyze our experience. METHODS: We performed a descriptive study that analyzed the PKB results at the fourth to sixth month and the first year post transplant of patients with kidney transplant followed in our hospital between January 2015 and June 2021. RESULTS: A total of 100 patients and 134 biopsy results were included, of which 71 were obtained between the fourth and sixth month and 63 at the first year...
October 31, 2022: Transplantation Proceedings
https://read.qxmd.com/read/36216509/the-abcd-of-kidney-allograft-pathology-the-beginning-of-the-beginning
#33
JOURNAL ARTICLE
Thangamani Muthukumar, Dany Anglicheau
No abstract text is available yet for this article.
November 2022: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/36252881/use-of-histologic-parameters-to-predict-glomerular-disease-progression-findings-from-the-china-kidney-biopsy-cohort-study
#34
MULTICENTER STUDY
Xiaodong Zhang, Fan Luo, Ruixuan Chen, Jie Shen, Xiaoting Liu, Yongjun Shi, Qiongqiong Yang, Ting Huang, Hua Li, Ying Hu, Qijun Wan, Chunbo Chen, Nan Jia, Yue Cao, Yanqin Li, Hao Zhao, Licong Su, Peiyan Gao, Xin Xu, Sheng Nie, Fan Fan Hou
RATIONALE & OBJECTIVE: Challenges in achieving valid risk prediction and stratification impede treatment decisions and clinical research design for patients with glomerular diseases. This study evaluated whether chronic histologic changes, when complementing other clinical data, improved the prediction of disease outcomes across a diverse group of glomerular diseases. STUDY DESIGN: Multicenter retrospective cohort study. SETTING & PARTICIPANTS: 4,982 patients with biopsy-proven glomerular disease who underwent native biopsy at 8 tertiary care hospitals across China in 2004-2020...
April 2023: American Journal of Kidney Diseases
https://read.qxmd.com/read/36180654/retroperitoneal-laparoscopic-renal-biopsy-an-8%C3%A2-year-experience-at-a-single-centre
#35
JOURNAL ARTICLE
Guming Zou, Haixin Chen, Xiaofeng Zhou, Wenge Li, Li Zhuo
PURPOSE: To present our experience and outcome of consecutive laparoscopic renal biopsy (LRB) in a series of Chinese patients over an 8 year period. METHODS: Between January 1, 2013, and December 31, 2020, 104 patients (M/F 71/33, age 43.6 ± 16.0 years) were enrolled. All patients underwent LRB for various indications, e.g., dialysis dependence (33.7%), serum levels of creatinine ≥ 442 μmol/L (20.2%), morbid obesity (18...
September 30, 2022: International Urology and Nephrology
https://read.qxmd.com/read/36153897/no-effect-of-desmopressin-administration-before-kidney-biopsy-on-the-risk-of-major-post-biopsy-bleeding
#36
JOURNAL ARTICLE
Minseon Cheong, Tae Yeon Lee, Jongmin Lee, Soon Bae Kim
BACKGROUND/AIMS: The most important complication of kidney biopsy is bleeding, and it is unclear whether desmopressin is effective in preventing it. Thus, the study was conducted to compare post-biopsy bleeding with or without desmopressin prescription prior to percutaneous kidney biopsy. METHODS: In this single-centered, retrospective, and observational study, 3,018 adult patients who underwent kidney biopsy between January 1, 2003 and March 31, 2019 at our institute were recruited...
January 2022: Nefrología
https://read.qxmd.com/read/36131134/risk-of-bleeding-after-percutaneous-native-kidney-biopsy-in-patients-receiving-low-dose-aspirin-a-single-center-retrospective-study
#37
JOURNAL ARTICLE
Francesco Fontana, Silvia Cazzato, Francesco Giaroni, Fabrizio Bertolini, Gaetano Alfano, Giacomo Mori, Silvia Giovanella, Giulia Ligabue, Riccardo Magistroni, Gianni Cappelli, Gabriele Donati
BACKGROUND: Although discontinuation of antiplatelet agents at least 5 days before kidney biopsy is commonly recommended, the evidence behind this practice is of low level. Indeed, few non-randomized studies previously showed an equivalent risk of bleeding in patients receiving aspirin therapy. METHODS: We conducted a single center retrospective study comparing the risk of complications after percutaneous native kidney biopsy in patients who received low-dose aspirin (ASA) within 5 days from biopsy and those who did not...
September 21, 2022: Journal of Nephrology
https://read.qxmd.com/read/36088901/intravenous-tranexamic-acid-in-percutaneous-kidney-biopsy-a-randomized-controlled-trial
#38
RANDOMIZED CONTROLLED TRIAL
Junichi Izawa, Keiichi Matsuzaki, Yoshihiko Raita, Genta Uehara, Norihiro Nishioka, Hiroyuki Yano, Ko Sudo, Masato Katsuren, Tomohiro Ohigashi, Takashi Sozu, Takashi Kawamura, Hitoshi Miyasato
BACKGROUND: Tranexamic acid is frequently reported to reduce bleeding-related complications in major surgery and trauma. We aimed to investigate whether tranexamic acid reduced hematoma size after percutaneous kidney biopsy. METHODS: We conducted a double-blind, parallel three-group, randomized placebo-controlled trial at a teaching hospital in Japan between January 2016 and July 2018. Adult patients with clinical indication for ultrasound-guided percutaneous biopsy of a native kidney were included...
2023: Nephron
https://read.qxmd.com/read/36062389/machine-learning-supported-interpretation-of-kidney-graft-elementary-lesions-in-combination-with-clinical-data
#39
JOURNAL ARTICLE
Marc Labriffe, Jean-Baptiste Woillard, Wilfried Gwinner, Jan-Hinrich Braesen, Dany Anglicheau, Marion Rabant, Priyanka Koshy, Maarten Naesens, Pierre Marquet
Interpretation of kidney graft biopsies using the Banff classification is still heterogeneous. In this study, extreme gradient boosting classifiers learned from two large training datasets (n = 631 and 304 cases) where the "reference diagnoses" were not strictly defined following the Banff rules but from central reading by expert pathologists and further interpreted consensually by experienced transplant nephrologists, in light of the clinical context. In three external validation datasets (n = 3744, 589, and 360), the classifiers yielded a mean ROC curve AUC (95%CI) of: 0...
December 2022: American Journal of Transplantation
https://read.qxmd.com/read/36066318/glomerular-macrophage-index-gmi-in-kidney-transplant-biopsies-is-associated-with-graft-outcome
#40
JOURNAL ARTICLE
Johan Mölne, Salmir Nasic, Verena Bröcker, Bernd Stegmayr, Marie Felldin, Björn Peters
BACKGROUND: Macrophages in renal transplants have been shown to participate in antibody-mediated rejection and are associated with impaired renal function. We calculated the glomerular macrophage index (GMI) in a large transplant biopsy cohort, studied its quantity in different diagnostic groups, to clarify its possible impact on graft survival. METHODS: GMI, defined as the mean number of macrophages in 10 glomeruli, was prospectively quantified in 1440 renal transplant biopsies over a 10-year period...
December 2022: Clinical Transplantation
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