Zhengzi Yi, Caixia Xi, Madhav C Menon, Paolo Cravedi, Fasika Tedla, Alan Soto, Zeguo Sun, Keyu Liu, Jason Zhang, Chengguo Wei, Man Chen, Wenlin Wang, Brandon Veremis, Monica Garcia-Barros, Abhishek Kumar, Danielle Haakinson, Rachel Brody, Evren U Azeloglu, Lorenzo Gallon, Philip O'Connell, Maarten Naesens, Ron Shapiro, Robert B Colvin, Stephen Ward, Fadi Salem, Weijia Zhang
Lesion scores on procurement donor biopsies are commonly used to guide organ utilization for deceased-donor kidneys. However, frozen sections present challenges for histological scoring, leading to inter- and intra-observer variability and inappropriate discard. Therefore, we constructed deep-learning based models to recognize kidney tissue compartments in hematoxylin &eosin-stained sections from procurement needle biopsies performed nationwide in years 2011-2020. To do this, we extracted whole-slide abnormality features from 2431 kidneys and correlated with pathologists' scores and transplant outcomes...
November 3, 2023: Kidney International