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Deepak Louis, Kiran More, Sapna Oberoi, Prakesh S Shah
BACKGROUND: Intravenous immunoglobulin (IVIg) is used in neonates with isoimmune haemolytic disease to prevent exchange transfusion (ET). However, studies supporting IVIg had methodological issues. OBJECTIVE: To update the systematic review of efficacy and safety of IVIg in neonates with isoimmune haemolytic disease. METHODS: MEDLINE, Embase databases and Cochrane Central Register of Controlled Trials (Cochrane Library) were searched (from inception to May 2013) for randomised or quasi-randomised controlled trials comparing IVIg with placebo/controls in neonates with isoimmune haemolytic disease without any language restriction...
July 2014: Archives of Disease in Childhood. Fetal and Neonatal Edition
Aleena M Wojcieszek, Owen M Stock, Vicki Flenady
BACKGROUND: Prelabour rupture of the membranes (PROM) at or near term (defined in this review as 36 weeks' gestation or beyond) increases the risk of infection for the woman and her baby. The routine use of antibiotics for women at the time of term PROM may reduce this risk. However, due to increasing problems with bacterial resistance and the risk of maternal anaphylaxis with antibiotic use, it is important to assess the evidence addressing risks and benefits in order to ensure judicious use of antibiotics...
October 29, 2014: Cochrane Database of Systematic Reviews
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