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By Alessandro Iadanza Interventional Cardiologist at Siena University Hospital
Jacob S Koruth, Anuradha Lala, Sean Pinney, Vivek Y Reddy, Srinivas R Dukkipati
The clinical use of ivabradine has and continues to evolve along channels that are predicated on its mechanism of action. It selectively inhibits the funny current (If ) in sinoatrial nodal tissue, resulting in a decrease in the rate of diastolic depolarization and, consequently, the heart rate, a mechanism that is distinct from those of other negative chronotropic agents. Thus, it has been evaluated and is used in select patients with systolic heart failure and chronic stable angina without clinically significant adverse effects...
October 3, 2017: Journal of the American College of Cardiology
Laurence Lucats, Bijan Ghaleh, Xavier Monnet, Patrice Colin, Alain Bizé, Alain Berdeaux
AIMS: Post-systolic wall thickening (PSWT) occurs after aortic valve closure. This waste of thickening does not participate in ejection. PSWT increases with myocardial ischaemia and stunning but the effects of anti-anginal drugs on PSWT during myocardial dysfunction remain unknown. The effects of two heart rate reducing agents, i.e. the beta-blocker atenolol and the selective I(f) current inhibitor ivabradine, were compared on PSWT. METHODS AND RESULTS: Coronary stenosis was calibrated in six conscious instrumented dogs to suppress increase in coronary blood flow during a 10 min treadmill exercise to induce myocardial stunning...
April 2007: European Heart Journal
X Monnet, B Ghaleh, P Colin, O P de Curzon, J F Giudicelli, A Berdeaux
We investigated the effects of the selective bradycardic agent ivabradine, an I(f) channel inhibitor, on exercise-induced ischemia and resulting myocardial stunning. Seven dogs were chronically instrumented to measure left ventricular (LV) wall thickening (Wth), aortic pressure and coronary blood flow (CBFv) (Doppler). Circumflex coronary artery stenosis was set up to suppress the increase in CBFv during a 10 min treadmill exercise. During exercise under saline, LVWth in the ischemic zone was depressed (-70 +/- 4%) and a prolonged myocardial stunning was subsequently observed...
December 2001: Journal of Pharmacology and Experimental Therapeutics
Elisabetta Nervo, Elena Menditto, Camillo Taglieri, Enrico Lombardo, Salvatore Piccolo, Mauro Feola
Ivabradine is a selective I(f) current inhibitor in the sinus node that decreases heart rate without negative inotropic effects. We report the case of an 88-year-old diabetic patient with arterial hypertension and peripheral arterial disease who experienced an antero-lateral non-ST-elevation myocardial infarction following post-surgical anemia. After admission, the patient complained of anginal pain at rest with ischemic alterations of ST-T at the ECG and mild increase in troponin T levels. According to the clinical status, the association of ivabradine with beta-blockers was started...
September 2010: Giornale Italiano di Cardiologia
G Cortez-Quiroga, C Rus-Mansilla, C Durán-Torralba, M Fernández-Guerrero, J Curotto-Grasiosi
No abstract text is available yet for this article.
March 2014: Medicina Intensiva
Jan-Christian Reil, Michele Robertson, Ian Ford, Jeffrey Borer, Michel Komajda, Karl Swedberg, Luigi Tavazzi, Michael Böhm
AIMS: Left bundle branch block (LBBB) increases morbidity and mortality in heart failure (HF). Heart rate reduction with ivabradine improves outcomes in patients with systolic HF. Therefore, we aimed to analyse the impact of LBBB on outcomes in patients with systolic HF as a function of heart rate, and the relationship between LBBB and the effect of treatment with ivabradine. METHODS AND RESULTS: Patients from the SHIFT (n = 6505) were divided into groups with (n = 912) or without (n = 5593) LBBB at baseline, and according to tertiles of heart rate (70-73, 74-80, and ≥81 b...
September 2013: European Journal of Heart Failure
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