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Retroperitoneal Sarcoma

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By HECTOR MARTINEZ SAID Melanoma Clinic Coordinator at NCI Mexico
Yuliya Olimpiadi, Suisui Song, James S Hu, George R Matcuk, Shefali Chopra, Burton L Eisenberg, Stephen F Sener, William W Tseng
Management of retroperitoneal soft tissue sarcomas (RP STS) can be very challenging. In contrast to the more common extremity STS, the two predominant histologic subtypes encountered in the retroperitoneum are well-differentiated/dedifferentiated liposarcoma and leiomyosarcoma. Surgery remains the mainstay of treatment for RP STS. Preoperative planning and anticipation of the need for resection of adjacent organs/structures are critical. The extent of surgery, including the role of compartmental resection, is still controversial...
August 2015: Current Oncology Reports
C Honoré, P Méeus, E Stoeckle, S Bonvalot
Four thousand new cases of soft tissue sarcomas are diagnosed each year in France, 23% of which are localized in the abdomen and pelvis; the treatment of non-metastatic tumor is based on wide surgical resection, the quality of which determines the long-term outcome. To ensure appropriate care, the European Society of Medical Oncology (ESMO) recommends that any patient with an unexplained soft tissue mass (of any size for deep lesions or of>5cm for superficial lesions) be referred to a specialized center with capacities for multidisciplinary team decision; appropriate imaging should be performed prior to treatment and a percutaneous image-guided needle biopsy should be routinely performed...
September 2015: Journal of Visceral Surgery
A I Semenova, S A Protsenko, Y I Komarov, G M Teletaeva, D H Latipova, A V Novik
Soft tissue sarcomas (STS) comprise a heterogeneous group of rare malignancies from mesenchymal tissues. The biology of STS causes high aggressiveness, poor prognosis due to early development of distant metastases and limited chemotherapeutic options due to tumor resistance. The paper considers the current principles of chemotherapy for early and metastatic disease. Results of own experience of advanced STS patients' treatment are presented and discussed.
2015: Voprosy Onkologii
Elizabeth H Baldini, Dian Wang, Rick L M Haas, Charles N Catton, Daniel J Indelicato, David G Kirsch, David Roberge, Kilian Salerno, Curtiland Deville, B Ashleigh Guadagnolo, Brian O'Sullivan, Ivy A Petersen, Cecile Le Pechoux, Ross A Abrams, Thomas F DeLaney
PURPOSE: Evidence for external beam radiation therapy (RT) as part of treatment for retroperitoneal sarcoma (RPS) is limited. Preoperative RT is the subject of a current randomized trial, but the results will not be available for many years. In the meantime, many practitioners use preoperative RT for RPS, and although this approach is used in practice, there are no radiation treatment guidelines. An international expert panel was convened to develop consensus treatment guidelines for preoperative RT for RPS...
July 1, 2015: International Journal of Radiation Oncology, Biology, Physics
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