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Hematological Parameters and Kidney

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106 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Qiongjing Yuan, Jinwei Wang, Zhangzhe Peng, Qiaoling Zhou, Xiangcheng Xiao, Yanyun Xie, Wei Wang, Ling Huang, Wenbin Tang, Danni Sun, Luxia Zhang, Fang Wang, Ming-Hui Zhao, Lijian Tao, Kevin He, Hui Xu
BACKGROUND: Chronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute to these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymphocyte ratio (NLR). We aimed to investigate the association of NLR with the progression of end stage of renal disease (ESRD), cardiovascular disease (CVD) and all-cause mortality in Chinese patients with stages 1-4 CKD. METHODS: Patients with stages 1-4 CKD (18-74 years of age) were recruited at 39 centers in 28 cities across 22 provinces in China since 2011...
March 15, 2019: Journal of Translational Medicine
Marcello Tonelli, Natasha Wiebe, Matthew T James, Christopher Naugler, Braden J Manns, Scott W Klarenbach, Brenda R Hemmelgarn
IMPORTANCE: Higher levels of red cell distribution width (RDW) are associated with adverse outcomes, especially in selected cohorts with or at risk for chronic disease. Whether higher RDW or the related parameter standard deviation of the red blood cell distribution (SD-RBC) can predict a broader range of outcomes in the general population is unknown. OBJECTIVE: To evaluate the association of RDW and SD-RBC with the risk of adverse outcomes in people from the general population...
2019: PloS One
Xi Bu, Lian Zhang, Peina Chen, Xiaoyan Wu
BACKGROUND: The purpose of this study was to determine the association of the neutrophil-to-lymphocyte ratio (NLR) measured at the time of admission to intensive unit (ICU) with acute kidney injury (AKI) in patients with sepsis and septic shock. In addition, we investigated whether the NLR affects in-hospital mortality in septic AKI patients. METHODS: In this retrospective study, a total of 222 adult patients with sepsis and septic shock were included, who were admitted to the ICU of Zhongnan Hospital of Wuhan University from January 2015 to December 2017...
March 7, 2019: International Immunopharmacology
Josefin Mörtberg, Kristina Lundwall, Fariborz Mobarrez, Håkan Wallén, Stefan H Jacobson, Jonas Spaak
BACKGROUND: Patients with chronic kidney disease (CKD) have a high risk of recurring thrombotic events following acute myocardial infarction (AMI). Microparticles (MPs) are circulating small vesicles shed from various cells. Platelet microparticles (PMPs) reflect platelet activation and endothelial microparticles (EMPs) reflect endothelial activation or dysfunction. Both increase following AMI, and may mediate important biological effects. We hypothesized that AMI patients with CKD have further elevated PMPs and EMPs compared with non-CKD patients, despite concurrent antithrombotic treatment...
March 1, 2019: BMC Nephrology
Ming Wu, Ying-Yi Luan, Jun-Fu Lu, Haoli Li, Hai-Chao Zhan, Yan-Hong Chen, Fan Zhang, Yu-Yu Tian, Zi-Long Yang, Yong-Ming Yao, Yong-Wen Feng
The aim of this study was to investigate the association between nadir platelet count and acute kidney injury (AKI) or 28-day all-cause mortality induced by hemorrhagic shock (HS), and to determine the cutoff value of nadir platelet count in HS clinical practice. This retrospective study included hospitalized patients enrolled in a tertiary-care teaching hospital from January 1, 2010 to December 31, 2015. Clinical data from HS admitted to the intensive care unit (ICU) were evaluated. Nadir platelet count was defined as the lowest values in the first 48 h...
February 27, 2019: Platelets
Yuthapong Wongmahisorn
OBJECTIVE: To evaluate the role of preoperative peripheral blood neutrophil-to-lymphocyte ratio in predicting early arteriovenous fistula failure. The impact of postoperative neutrophil-to-lymphocyte ratio on arteriovenous fistula failure was also investigated. METHODS: Medical records from 470 patients who underwent first-time arteriovenous fistula creation were studied. Demographic, clinical, and laboratory data were obtained. Receiver operating characteristic curves were constructed to determine the optimal cutoff values of preoperative and postoperative neutrophil-to-lymphocyte ratios for predicting early arteriovenous fistula failure...
February 10, 2019: Journal of Vascular Access
Alaleh Gheissari, Bahar Dehghan, Bijan Ghaed Sharafi, Amin Abedini, Alireza Merrikhi, Yahya Madihi, Mehryar Mehrkash
Cardiovascular disease (CVD) is the major cause of death in children with end stage renal disease (ESRD). Echocardiography and Doppler ultrasound are useful devices for diagnosing cardiovascular abnormalities in such patients. However, they are expensive, difficult to perform as a routine and not available in many centers. Therefore, finding a more accessible and inexpensive method for CVD evaluation such as biomarkers is needed. The aim of this study was to evaluate the relationship between mean platelet volume (MPV) as a routine hematological parameter with cardiac mechanics characteristics in children with ESRD...
January 23, 2019: Therapeutic Apheresis and Dialysis
Alissa Dratch, Carola-Ellen Kleine, Elani Streja, Melissa Soohoo, Christina Park, Jui-Ting Hsiung, Connie M Rhee, Yoshitsugu Obi, Miklos Z Molnar, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
BACKGROUND/AIMS: Anemia is common in patients with advanced chronic kidney disease (CKD). A proportion of patients present with macrocytic anemia, manifested by elevated mean corpuscular volume (MCV), which has been associated with worse outcomes in CKD patients. However, it is unknown whether elevated MCV is associated with higher mortality risk in incident hemodialysis (HD) patients. METHODS: This retrospective observational cohort study examined all-cause, cardiovascular, and infectious mortality associations with both baseline and time-varying MCV in 109,501 incident HD patients using Cox proportional hazards models with 3 levels of hierarchical multivariable adjustment...
January 9, 2019: Nephron
Hikmet Tekce, Buket Kin Tekce, Gulali Aktas, Mehmet Tanrisev, Mustafa Sit
Background. Red cell distribution width (RDW) has been used as a marker of iron deficiency; however, it is accepted as a marker of cardiovascular survival. We aimed to study RDW levels in hemodialysis (HD) patients and the association between RDW and inflammatory, nutritional, and volume markers. Methods. We included 296 HD patients with sufficient iron storage and without anemia or hypervolemia. We grouped patients into four groups according to clinical parameters, albumin, and C-reactive protein (CRP). Results...
2014: International Journal of Nephrology
Junlin Zhang, Rui Zhang, Yiting Wang, Hanyu Li, Qianqian Han, Yucheng Wu, Shanshan Wang, Ruikun Guo, Tingli Wang, Li Li, Fang Liu
BACKGROUND: Red cell distribution width (RDW) has been reported to be involved in metabolic syndrome and cardiovascular events. Patients with diabetic nephropathy (DN) are often found to be with high level of RDW. The aim of this study was to explore whether RDW was associated with DN severity and progression in patients with type-2 diabetes mellitus (T2DM). METHODS: A total of 175 T2DM patients with biopsy-proven DN were enrolled. The baseline clinical and pathologic data of these patients was extracted from the medical records...
November 2018: Renal Failure
Junlin Zhang, Rui Zhang, Yiting Wang, Yucheng Wu, Hanyu Li, Qianqian Han, Ruikun Guo, Tingli Wang, Jiali Wang, Pramesh Grung, Fang Liu
BACKGROUND: Chronic low-grade inflammation related to diabetic nephropathy (DN) may affect the serum neutrophil-lymphocyte ratio (NLR). We aimed to examine the cross-sectional relationships of NLR with renal function and structural lesions of DN in patients with type 2 diabetes mellitus (T2DM). METHODS: The study retrospectively included 247 patients with T2DM and biopsy-proven DN. The severity of different pathological lesions was evaluated based on the criteria of Renal Pathology Society...
October 22, 2018: Nephrology
Benji Wang, Huaya Lu, Yuqiang Gong, Binyu Ying, Bihuan Cheng
Background: Several investigators have sought risk factors for mortality in acute kidney injury (AKI). However, no epidemiological studies have investigated the impact of red blood cell distribution width (RDW) on prognosis for critically ill patients with AKI. The aim of this study was to investigate the association of RDW with mortality in these patients. Methods: We analyzed data from the MIMIC-III. RDW was measured upon ICU admission. The association between RDW and mortality of AKI was determined using a multivariate logistic regression and was expressed as the adjusted odds ratio with associated 95% confidence interval (CI)...
2018: BioMed Research International
Lai Lai Fan, Yi Jun Wang, Cun Jin Nan, Ying He Chen, Hong Xia Su
BACKGROUND: Inflammation plays a critical role in the development of acute kidney injury (AKI). Neutrophil-lymphocyte ratio (NLR) is a biomarker of systemic inflammation used to predict the prognostic outcome of several diseases. We conducted a retrospective cohort study to investigate if NLR can be used as a biomarker to predict the mortality of AKI. METHODS AND RESULTS: Records of critically ill patients with AKI were extracted from the Medical Information Mart for Intensive Care Database III version 1...
September 7, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Wafaa M Soliman, Nahed M Sherif, Iman M Ghanima, Mohja A El-Badawy
OBJECTIVES: To investigate the role of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as activity markers in systemic lupus erythematosus (SLE) without nephritis and lupus nephritis (LN) patients. PATIENTS AND METHODS: This study included 60 SLE patients with LN, 60 SLE patients without renal involvement and 30 healthy controls. We analyzed correlations between NLR and PLR and both disease activity and renal affection. RESULTS: The NLR of SLE patients was much higher than those of the controls...
August 27, 2018: Reumatología Clinica
Dragan Djordjevic, Goran Rondovic, Maja Surbatovic, Ivan Stanojevic, Ivo Udovicic, Tamara Andjelic, Snjezana Zeba, Snezana Milosavljevic, Nikola Stankovic, Dzihan Abazovic, Jasna Jevdjic, Danilo Vojvodic
Background: Neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume-to-platelet count (MPV/PC) ratio are readily available parameters that might have discriminative power regarding outcome. The aim of our study was to assess prognostic value of these biomarkers regarding outcome in critically ill patients with secondary sepsis and/or trauma. Methods: A total of 392 critically ill and injured patients, admitted to surgical ICU, were enrolled in a prospective observational study...
2018: Mediators of Inflammation
Zhouping Zou, Yamin Zhuang, Lan Liu, Bo Shen, Jiarui Xu, Wuhua Jiang, Zhe Luo, Jie Teng, Chunsheng Wang, Xiaoqiang Ding
BACKGROUND: The aim of the study was to explore associations between elevated red cell distribution width (RDW) and acute kidney injury (AKI) in patients undergoing cardiac surgery (CS-AKI). METHODS: Preoperative, intraoperative and postoperative data of 10,274 patients undergoing cardiac surgery, including demographic data, were prospectively collected from January 2009 to December 2014. Propensity score matching was used on the basis of clinical characteristics and preoperative variables...
August 14, 2018: BMC Cardiovascular Disorders
Chew-Teng Kor, Yao-Peng Hsieh, Chia-Chu Chang, Ping-Fang Chiu
Recently, both red cell distribution width (RDW) and mean corpuscular volume (MCV) have been associated with unfavorable outcomes in several medical conditions. Therefore, we conducted this retrospective study of 1075 patients with stage 3-5 chronic kidney disease to investigate whether interactions between RDW and MCV influence the risk of mortality. These patients were divided into four groups: group A (n = 415), RDW ≤ 14.9% and MCV ≤ 91.6 fL; group B (n = 232), RDW > 14.9% and MCV ≤ 91...
August 8, 2018: Scientific Reports
Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
BACKGROUND: Neutrophil to lymphocyte ratio (NLR) was introduced to predict poor prognosis in various diseases, but not all variants of ANCA-associated vasculitis (AAV). In this study, we aimed to investigate whether NLR at diagnosis can estimate vasculitis activity at diagnosis and poor prognosis during follow-up in patients with AAV. METHODS: We retrospectively reviewed the medical records of 160 patients with AAV. We collected clinical and laboratory data at diagnosis and obtained remission and death as poor prognosis...
July 31, 2018: BMC Nephrology
Abha Singh, Ruchi Varma
Objective: To evaluate the role of platelet indices in preeclampsia and eclampsia. Methods: An observational analytical study was conducted in Department of Obstetrics and Gynaecology, Ambedkar Hospital, Pandit Jawaharlal Nehru Memorial Medical College, Raipur. It was performed on 150 women between March 2015 and February 2016; among them, 42 were taken as controls, 36 were preeclampsia and 72 were eclampsia. Their platelet count and platelet indices were done, analyzed and compared...
August 2018: Journal of Obstetrics and Gynaecology of India
Hakan Parlar, Hüseyin Şaşkın
OBJECTIVE: In this study, we investigated the role of two of the recent biomarkers of inflammation on the development of acute kidney injury in the early postoperative period of isolated coronary artery bypass grafting. METHODS: Three hundred and eleven patients, who underwent isolated coronary artery bypass grafting with cardiopulmonary bypass by the same surgery team in our clinic between May 2010 and October 2014, who had a preoperative serum creatinine level lower than 1...
May 2018: Brazilian Journal of Cardiovascular Surgery
2018-07-27 08:09:42
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