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Colo de Útero

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8 papers 25 to 100 followers
By Alessandro Franciscon doctor
Karen Lim, William Small, Lorraine Portelance, Carien Creutzberg, Ina M Jürgenliemk-Schulz, Arno Mundt, Loren K Mell, Nina Mayr, Akila Viswanathan, Anuja Jhingran, Beth Erickson, Jennifer De los Santos, David Gaffney, Catheryn Yashar, Sushil Beriwal, Aaron Wolfson, Alexandra Taylor, Walter Bosch, Issam El Naqa, Anthony Fyles
PURPOSE: Accurate target definition is vitally important for definitive treatment of cervix cancer with intensity-modulated radiotherapy (IMRT), yet a definition of clinical target volume (CTV) remains variable within the literature. The aim of this study was to develop a consensus CTV definition in preparation for a Phase 2 clinical trial being planned by the Radiation Therapy Oncology Group. METHODS AND MATERIALS: A guidelines consensus working group meeting was convened in June 2008 for the purposes of developing target definition guidelines for IMRT for the intact cervix...
February 1, 2011: International Journal of Radiation Oncology, Biology, Physics
Loren K Mell, Igor Sirák, Lichun Wei, Rafal Tarnawski, Umesh Mahantshetty, Catheryn M Yashar, Michael T McHale, Ronghui Xu, Gordon Honerkamp-Smith, Ruben Carmona, Mary Wright, Casey W Williamson, Linda Kasaová, Nan Li, Stephen Kry, Jeff Michalski, Walter Bosch, William Straube, Julie Schwarz, Jessica Lowenstein, Steve B Jiang, Cheryl C Saenz, Steve Plaxe, John Einck, Chonlakiet Khorprasert, Paul Koonings, Terry Harrison, Mei Shi, A J Mundt
PURPOSE: To test the hypothesis that intensity modulated radiation therapy (IMRT) reduces acute hematologic and gastrointestinal (GI) toxicity for patients with locoregionally advanced cervical cancer. METHODS AND MATERIALS: We enrolled patients with stage IB-IVA cervical carcinoma in a single-arm phase II trial involving 8 centers internationally. All patients received weekly cisplatin concurrently with once-daily IMRT, followed by intracavitary brachytherapy, as indicated...
March 1, 2017: International Journal of Radiation Oncology, Biology, Physics
W A Peters, P Y Liu, R J Barrett, R J Stock, B J Monk, J S Berek, L Souhami, P Grigsby, W Gordon, D S Alberts
PURPOSE: To determine whether the addition of cisplatin-based chemotherapy (CT) to pelvic radiation therapy (RT) will improve the survival of early-stage, high-risk patients with cervical carcinoma. PATIENTS AND METHODS: Patients with clinical stage IA(2), IB, and IIA carcinoma of the cervix, initially treated with radical hysterectomy and pelvic lymphadenectomy, and who had positive pelvic lymph nodes and/or positive margins and/or microscopic involvement of the parametrium were eligible for this study...
April 2000: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Marvin Rotman, Alexander Sedlis, Marion R Piedmonte, Brian Bundy, Samuel S Lentz, Laila I Muderspach, Richard J Zaino
PURPOSE: To investigate, in a phase III randomized trial, whether postoperative external-beam irradiation to the standard pelvic field improves the recurrence-free interval and overall survival (OS) in women with Stage IB cervical cancers with negative lymph nodes and certain poor prognostic features treated by radical hysterectomy and pelvic lymphadenectomy. METHODS AND MATERIALS: Eligible patients had Stage IB cervical cancer with negative lymph nodes but with 2 or more of the following features: more than one third (deep) stromal invasion, capillary lymphatic space involvement, and tumor diameter of 4 cm or more...
May 1, 2006: International Journal of Radiation Oncology, Biology, Physics
Daniel M Trifiletti, Samuel Swisher-McClure, Timothy N Showalter, Sarah E Hegarty, Surbhi Grover
PURPOSE: To review the National Cancer Database (NCDB) to evaluate postoperative high-risk cervical cancer patients for factors associated with a benefit from chemoradiation therapy (CRT) over external beam radiation therapy alone (EBRT). METHODS AND MATERIALS: The National Cancer Database was queried for women with cervical cancer treated with hysterectomy and adjuvant EBRT from 2002 to 2012. Only patients with pathologic lymph node involvement (LN+), positive surgical margins, and/or parametrial invasion were included in our analysis (on the basis of Peter's criteria)...
December 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Nikola Cihoric, Coya Tapia, Kamilla Krüger, Daniel M Aebersold, Bernd Klaeser, Kristina Lössl
BACKGROUND: To evaluate toxicity and outcome of intensity modulated radiotherapy (IMRT) with simultaneous integrated boost (SIB) to the positive lymph nodes in patients with loco-regional advanced cervical cancer (LRACC). METHODS: The study population comprised ten patients with 18FDG-PET\CT positive lymph nodes (LNs), who underwent chemoradiation with IMRT and SIB. A dose of 50.4 Gy, in daily fractions of 1.8 Gy, was delivered to primary tumor and draining LNs...
March 25, 2014: Radiation Oncology
M Rotman, T F Pajak, K Choi, M Clery, V Marcial, P W Grigsby, J Cooper, M John
OBJECTIVES: To investigate whether irradiation to the standard pelvic field only improves the response rate and survival in comparison with pelvic plus para-aortic irradiation in patients with high-risk cervical carcinoma, and to investigate patterns of failure and treatment-related toxicity. DESIGN: Randomized controlled trial from November 1979 to October 1986, with stratification by histology, para-aortic nodal status, and International Federation of Gynecology and Obstetrics (FIGO) stage...
August 2, 1995: JAMA: the Journal of the American Medical Association
A Sedlis, B N Bundy, M Z Rotman, S S Lentz, L I Muderspach, R J Zaino
OBJECTIVE: The objective of this study was to evaluate the benefits and risk of adjuvant pelvic radiotherapy aimed at reducing recurrence in women with Stage IB cervical cancer treated by radical hysterectomy and pelvic lymphadenectomy. METHODS: Two hundred seventy-seven eligible patients were entered with at least two of the following risk factors: >1/3 stromal invasion, capillary lymphatic space involvement, and large clinical tumor diameter. Of 277 patients, 137 were randomized to pelvic radiotherapy (RT) and 140 to no further treatment (NFT)...
May 1999: Gynecologic Oncology
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