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Case control studies using EHR

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5 papers 0 to 25 followers Examples of case control studies using electronic health records
Yana Vinogradova, Carol Coupland, Julia Hippisley-Cox
OBJECTIVE: To investigate the association between use of combined oral contraceptives and risk of venous thromboembolism, taking the type of progestogen into account. DESIGN: Two nested case-control studies. SETTING: General practices in the United Kingdom contributing to the Clinical Practice Research Datalink (CPRD; 618 practices) and QResearch primary care database (722 practices). PARTICIPANTS: Women aged 15-49 years with a first diagnosis of venous thromboembolism in 2001-13, each matched with up to five controls by age, practice, and calendar year...
May 26, 2015: BMJ: British Medical Journal
Katherine A McGlynn, Katrina Hagberg, Jie Chen, Barry I Graubard, W Thomas London, Susan Jick, Vikrant V Sahasrabuddhe
BACKGROUND: Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are widely prescribed to reduce cholesterol levels. Studies have suggested that statins are associated with reduced risk of liver cancer, but much of the evidence is from regions of the world with high liver cancer incidence rates. The current study examined the statins-liver cancer relationship in a low-rate region and examined the effects of preexisting liver disease and diabetes on that association. METHODS: A nested case-control study was conducted within the United Kingdom's Clinical Practice Research Datalink (CPRD)...
April 2015: Journal of the National Cancer Institute
J-L Faillie, K B Filion, V Patenaude, P Ernst, L Azoulay
AIMS: To determine whether the use of dipeptidyl peptidase-4 (DPP-4) inhibitors is associated with an increased risk of community-acquired pneumonia. METHODS: The UK Clinical Practice Research Datalink and the Hospital Episodes Statistics database were used to conduct a nested case-control analysis within a cohort of new users of antidiabetic drugs between 2007 and 2012. Incident cases of hospitalization for community-acquired pneumonia were matched with up to 20 controls on age, duration of treated diabetes, calendar year and duration of follow-up...
April 2015: Diabetes, Obesity & Metabolism
Sarah Walker, Chris Hyde, William Hamilton
BACKGROUND: Breast cancer is the most common cancer in the UK. GPs are encouraged to refer all women whose symptoms may represent cancer, rather than selecting those at highest risk. AIM: To identify and quantify features of breast cancer in primary care. DESIGN AND SETTING: A UK case-control study using the Clinical Practice Research Database (CPRD). METHOD: Possible features of breast cancer were identified in the year before diagnosis, and odds ratios calculated using conditional logistic regression...
December 2014: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Chieko Ishiguro, Xi Wang, Lin Li, Susan Jick
BACKGROUND: The evidence to date on the relationship between antipsychotic drugs and the risk of venous thromboembolism (VTE) is limited. PURPOSE: Our aim was to examine the association between the use of typical and atypical antipsychotics and risk of VTE and to assess the effects of dose and duration of use. METHODS: Among users of typical or atypical antipsychotics between 1998 and 2012 in the Clinical Practice Research Datalink, we identified all VTE cases aged 20-59 years with no major risk factors for VTE...
November 2014: Pharmacoepidemiology and Drug Safety
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