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JOURNAL ARTICLE
Sayaka Toki, Sei-ichiro Motegi, Kazuya Yamada, Akihiko Uchiyama, Sahori Kanai, Masayoshi Yamanaka, Osamu Ishikawa
Localized scleroderma (LSc) primarily affects skin, whereas systemic sclerosis (SSc) affects skin and various internal organs. LSc and SSc are considered to be basically different diseases, and there is no transition between them. However, LSc and SSc have several common characteristics, including endothelial cell dysfunction, immune activation, and excess fibrosis of the skin, and there exist several SSc cases complicated with LSc during the course of SSc. Clinical and laboratory characteristics of SSc patients with LSc remain unclear...
March 2015: Journal of Dermatology
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