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14 papers 0 to 25 followers
Kristen P Massimino, Maxine S Jochelson, Imelda E Burgan, Michelle Stempel, Monica Morrow
OBJECTIVE: The aim of this study was to determine the rate of non-palpable cancer detection and benign biopsy rates for follow-up mammograms in elderly breast cancer survivors. METHODS: Women 80 years of age and older who underwent operation for ductal carcinoma in situ or invasive breast cancer from 2005 to 2010 and who had at least 6 months of follow-up were identified from a single-institution, prospectively maintained, Health Insurance Portability and Accountability Act (HIPAA)-compliant database...
October 2016: Annals of Surgical Oncology
H Karanlik, I Ozgur, N Cabioglu, F Sen, K Erturk, B Kilic, S Onder, M Deniz, E Yavuz, A Aydiner
BACKGROUND: The aim of this study is to compare the clinical outcome in T2 breast cancer patients who underwent preoperative chemotherapy (PC) and who did not. The study also tried to define a subgroup of patients, who are more beneficial after PC in terms of lower re-excision rates, better cosmetic results and local recurrence free survival. MATERIALS AND METHODS: 251 consecutive patients treated for nonmetastatic T2 invasive breast cancer were analyzed retrospectively...
September 2015: European Journal of Surgical Oncology
Chafika Mazouni, Alix Naveau, Aminata Kane, Ariane Dunant, Jean-Rémi Garbay, Nicolas Leymarie, Benjamin Sarfati, Suzette Delaloge, Françoise Rimareix
OBJECTIVE: The purpose of this study was to evaluate the benefit of Oncoplastic Breast Conserving Surgery (BCS) compared to standard BCS after primary CT, in terms of oncologic safety and cosmetic outcomes. BACKGROUND: The development of new drugs has led to greater use of primary chemotherapy (CT) for bulky breast cancer (BC) and has allowed wider indications for conservative surgery. PATIENTS AND METHODS: We identified 259 patients consecutively treated with BCS for primary BC from January 2002 to November 2010...
December 2013: Breast: Official Journal of the European Society of Mastology
Jung Hoon Cho, Ji Min Park, Hyung Seok Park, Seho Park, Seung Il Kim, Byeong-Woo Park
BACKGROUND: Breast-conserving surgery (BCS) in patients with large tumors shrunk by neoadjuvant chemotherapy (NCT) remains controversial. We investigated oncologic outcomes of BCS in patients receiving NCT to treat locally advanced breast cancer (LABC). METHODS: We reviewed 1,994 patients who underwent surgery with/without NCT. Patients were categorized into three groups according to treatment methods: initial BCS, BCS after NCT (NCT-BCS), and mastectomy after NCT (NCT-MX)...
December 2013: Journal of Surgical Oncology
Hee-Chul Shin, Wonshik Han, Hyeong-Gon Moon, Seock-Ah Im, Woo Kyung Moon, In-Ae Park, Sung Jun Park, Dong-Young Noh
BACKGROUND: We conducted a retrospective study to evaluate the local recurrence (LR) rate depending on the use of neoadjuvant chemotherapy (NCT) and to determine the oncologic safety of breast-conserving surgery (BCS) after NCT by comparing LR between patients treated with BCS and mastectomy in clinical stage III breast cancer patients. PATIENTS AND METHODS: Between 2004 and 2007, 166 patients underwent BCS or mastectomy after NCT (NCT group) and 193 patients underwent surgery first (surgery group) in clinical stage III breast cancer patients...
August 2013: Annals of Surgical Oncology
Emmanuel Barranger, Julie Antomarchi, Emmanuel Chamorey, Constance Cavrot, Bernard Flipo, Philippe Follana, Isabelle Peyrottes, Claire Chapellier, Jean Marc Ferrero, Tarik Ihrai
BACKGROUND: The aim of this study was to assess the rate of breast-conserving surgery (BCS) after neoadjuvant chemotherapy (nCT) in patients for whom mastectomy (MT) was, initially, the only conceivable surgical option. PATIENTS AND METHODS: Between 2007 and 2012, 168 patients from a single center received nCT. Among these patients, we focused on the ones who received nCT (n = 119, [70.8%]) to decrease tumor size and thus to potentially allow a conservative surgical treatment...
October 2015: Clinical Breast Cancer
Patricia Cortazar, Lijun Zhang, Michael Untch, Keyur Mehta, Joseph P Costantino, Norman Wolmark, Hervé Bonnefoi, David Cameron, Luca Gianni, Pinuccia Valagussa, Sandra M Swain, Tatiana Prowell, Sibylle Loibl, D Lawrence Wickerham, Jan Bogaerts, Jose Baselga, Charles Perou, Gideon Blumenthal, Jens Blohmer, Eleftherios P Mamounas, Jonas Bergh, Vladimir Semiglazov, Robert Justice, Holger Eidtmann, Soonmyung Paik, Martine Piccart, Rajeshwari Sridhara, Peter A Fasching, Leen Slaets, Shenghui Tang, Bernd Gerber, Charles E Geyer, Richard Pazdur, Nina Ditsch, Priya Rastogi, Wolfgang Eiermann, Gunter von Minckwitz
BACKGROUND: Pathological complete response has been proposed as a surrogate endpoint for prediction of long-term clinical benefit, such as disease-free survival, event-free survival (EFS), and overall survival (OS). We had four key objectives: to establish the association between pathological complete response and EFS and OS, to establish the definition of pathological complete response that correlates best with long-term outcome, to identify the breast cancer subtypes in which pathological complete response is best correlated with long-term outcome, and to assess whether an increase in frequency of pathological complete response between treatment groups predicts improved EFS and OS...
July 12, 2014: Lancet
Sibylle Loibl, Gunter von Minckwitz, Michael Untch, Carsten Denkert
Within 2 decades, neoadjuvant therapy (NAT) has become a standard treatment option in breast cancer. The advantage of NAT is the ability to monitor the treatment effect. Pathological complete response (pCR) after NAT is a very good predictor for long-term outcome. Clinical factors, such as age and body mass index, as well as recently identified biomarkers can predict the chance of achieving a pCR. Hormone-receptor status, proliferation markers, immune infiltrates and genetic alterations, such as germline BRCA and PIK3CA, can now be measured almost on a routine basis due to the decreased analysis costs...
2014: Oncology Research and Treatment
Gianpiero Manca, Domenico Rubello, Elisa Tardelli, Francesco Giammarile, Sara Mazzarri, Giuseppe Boni, Sotirios Chondrogiannis, Maria Cristina Marzola, Serena Chiacchio, Matteo Ghilli, Manuela Roncella, Duccio Volterrani, Patrick M Colletti
Axillary lymph node status, a major prognostic factor in early-stage breast cancer, provides information important for individualized surgical treatment. Because imaging techniques have limited sensitivity to detect metastasis in axillary lymph nodes, the axilla must be explored surgically. The histology of all resected nodes at the time of axillary lymph node dissection (ALND) has traditionally been regarded as the most accurate method for assessing metastatic spread of disease to the locoregional lymph nodes...
February 2016: Clinical Nuclear Medicine
Jordan D Frey, Michael Alperovich, Jennifer Chun Kim, Deborah M Axelrod, Richard L Shapiro, Mihye Choi, Freya R Schnabel, Nolan S Karp, Amber A Guth
INTRODUCTION: Long-term oncologic outcomes in nipple-sparing mastectomy (NSM) continue to be defined. Rates of locoregional recurrence for skin-sparing mastectomy (SSM) and NSM in the literature range from 0% to 14.3%. We investigated the outcomes of NSM at our institution. METHODS: Patients undergoing NSM at our institution from 2006 to 2014 were identified and outcomes were analyzed. RESULTS: From 2006 to 2014, 319 patients (555 breasts) underwent NSM...
January 2016: Journal of Surgical Oncology
Eran Nizri, Ofer Merimsky, Guy Lahat
Breast sarcomas are rare mesenchymal-derived breast tumors. The small number of patients, the different histological subtypes, and the variation in clinical practice impairs the ability to draw firm practice recommendations. Patient management is often extrapolated from other soft tissue sarcomas, mostly of the extremities in which more clinical data is available. Surgical resection with negative margins is the goal of treatment, irrespective of the surgical procedure; the implication of radiation and chemotherapy is variable...
June 2014: Expert Review of Anticancer Therapy
Adel Denewer, Omar Farouk, Sherif Kotb, Ahmed Setit, Seham Abd El-Khalek, Mosab Shetiwy
Breast reconstruction is considered as an integrated part of the modern breast surgery. The aim of this study is to evaluate whether immediate autologous breast reconstruction influences QOL and patient satisfaction outcomes among Egyptian women with breast cancer in comparison to the traditional mastectomy. This is a prospective study in which 200 Egyptian women with non metastatic breast cancer were included; group I (100 patients) underwent sparing mastectomy with immediate autologous breast reconstruction and group II (100 patients) underwent traditional mastectomy...
June 2012: Breast Cancer Research and Treatment
Alvin C Kwok, Isak A Goodwin, Jian Ying, Jayant P Agarwal
BACKGROUND: This study's purpose was to examine the national rate of breast cancer patients undergoing bilateral mastectomy (BM) and immediate breast reconstruction (IBR) and their associated complication rates. METHODS: Using the National Surgical Quality Improvement Program database, breast cancer patients undergoing mastectomy between 2005 and 2012 were identified. Rates in BM and IBR as well as associated complication rates were evaluated. Logistic regression was used to identify predictors of BM, IBR, and complications...
September 2015: American Journal of Surgery
Yu Liu, Yaohui Wang, Liheng Zhou, Kai Yin, Wenjin Yin, Jinsong Lu
BACKGROUND: It is controversial whether surgery during different menstrual phases (a kind of host milieu may influence biological characteristics of micrometastatic foci) affects clinical outcomes. METHODS: Survival outcomes were compared between patients who underwent surgery during the follicular (cycle days 1 to 14) and luteal (days 15 to 31) phases. A range of cutoff days from day 10 to 22 was used to observe the risk trend. RESULTS: The follicular phase was associated with a more favorable prognosis than the luteal phase in disease-free survival (DFS) [hazard ratio (HR) ...
September 2015: American Journal of Surgery
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