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Borderline Personality Disorder

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40 papers 100 to 500 followers
Natalie A Izurieta Hidalgo, Rieke Oelkers-Ax, Krisztina Nagy, Falk Mancke, Martin Bohus, Sabine C Herpertz, Katja Bertsch
BACKGROUND: Borderline personality disorder (BPD) is characterized by a negative perception of others. Previous studies have revealed deficits and biases in facial emotion recognition. This study investigates the behavioural and electrophysiological correlates underlying facial emotion processing in individuals with BPD. METHODS: The present study was conducted between July 2012 and May 2014. In an emotion classification task, unmedicated female patients with BPD as well as healthy women had to classify faces displaying blends of anger and happiness while the electroencephalogram was recorded...
January 2016: Journal of Psychiatry & Neuroscience: JPN
David L Perez, David R Vago, Hong Pan, James Root, Oliver Tuescher, Benjamin H Fuchs, Lorene Leung, Jane Epstein, Nicole M Cain, John F Clarkin, Mark F Lenzenweger, Otto F Kernberg, Kenneth N Levy, David A Silbersweig, Emily Stern
AIMS: Borderline personality disorder (BPD) is characterized by self-regulation deficits, including impulsivity and affective lability. Transference-focused psychotherapy (TFP) is an evidence-based treatment proven to reduce symptoms across multiple cognitive-emotional domains in BPD. This pilot study aimed to investigate neural activation associated with, and predictive of, clinical improvement in emotional and behavioral regulation in BPD following TFP. METHODS: BPD subjects (n = 10) were scanned pre- and post-TFP treatment using a within-subjects design...
January 2016: Psychiatry and Clinical Neurosciences
Borwin Bandelow, Dirk Wedekind
Around half the inmates in prison institutions have antisocial personality disorder (ASPD). A recent theory has proposed that a dysfunction of the endogenous opioid system (EOS) underlies the neurobiology of borderline personality disorder (BPD). In the present theoretical paper, based on a comprehensive database and hand search of the relevant literature, this hypothesis is extended to ASPD, which may be the predominant expression of EOS dysfunction in men, while the same pathology underlies BPD in women. According to evidence from human and animal studies, the problematic behaviours of persons with antisocial, callous, or psychopathic traits may be seen as desperate, unconscious attempts to stimulate their deficient EOS, which plays a key role in brain reward circuits...
November 2015: Human Psychopharmacology
Ana Martín-Blanco, Marc Ferrer, Joaquim Soler, Maria Jesús Arranz, Daniel Vega, Joana Bauzà, Natalia Calvo, Matilde Elices, Cristina Sanchez-Mora, Iris García-Martinez, Juliana Salazar, Marta Ribases, Cristina Carmona, Mónica Prat, Juan C Pascual
This study investigated the possible association of 40 polymorphisms within 4 noradrenergic genes with BPD risk and the modulating effect of childhood trauma on these associations in 481 BPD subjects and 442 controls. COMT rs5993882, DBH rs77905 and SLC6A2 rs1814270 showed associations with BPD, which were modulated by childhood trauma. However, none of these findings survived Bonferroni correction. Further investigation is needed to clarify the involvement of these genes in BPD pathogenesis.
September 30, 2015: Psychiatry Research
Christina Andreou, Julia Kleinert, Saskia Steinmann, Ulrike Fuger, Gregor Leicht, Christoph Mulert
OBJECTIVES: Previous electrophysiological studies have confirmed impaired reward processing in patients with BPD. However, it is not clear which aspects of reward processing are affected and which brain regions are involved. The present study investigated both evoked and induced event-related oscillations (EROs) to feedback events (thought to represent different aspects of feedback processing), and used source localization (sLORETA) to assess activity in two areas known to contribute to reward processing, the dorsomedial prefrontal/anterior cingulate cortex (dmPFC/ACC) and the orbitofrontal cortex (OFC)...
2015: World Journal of Biological Psychiatry
Julian Koenig, Andrew H Kemp, Nicole R Feeling, Julian F Thayer, Michael Kaess
Borderline personality disorder (BPD) is the most common personality disorder in clinical settings. It is characterized by negative affectivity, emotional liability, anxiety, depression, as well as disinhibition (i.e., impulsivity and risk taking), all of which have been linked to lower resting state vagal tone, which may be indexed by vagally-mediated heart rate variability (vmHRV). Here, we aimed to quantify the current evidence on alterations in resting state vmHRV in individuals with BPD, relative to healthy controls...
January 4, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
Ana Martín-Blanco, Marc Ferrer, Joaquim Soler, Maria Jesús Arranz, Daniel Vega, Natalia Calvo, Matilde Elices, Cristina Sanchez-Mora, Iris García-Martinez, Juliana Salazar, Cristina Carmona, Joana Bauzà, Mónica Prat, Víctor Pérez, Juan C Pascual
Current knowledge suggests that borderline personality disorder (BPD) results from the interaction between genetic and environmental factors. Research has mainly focused on monoaminergic genetic variants and their modulation by traumatic events, especially those occurring during childhood. However, to the best of our knowledge, there are no studies on the genetics of hypothalamus-pituitary-adrenal (HPA) axis, despite its vulnerability to early stress and its involvement in BPD pathogenesis. The aim of this study was to investigate the contribution of genetic variants in the HPA axis and to explore the modulating effect of childhood trauma in a large sample of BPD patients and controls...
June 2016: European Archives of Psychiatry and Clinical Neuroscience
Ehud Bodner, Amit Shrira, Hagai Hermesh, Menachem Ben-Ezra, Iulian Iancu
This study examines the relationship between psychiatrists׳ fear of death and negative emotions toward patients with borderline personality disorder (BPD). A survey (N=120) demonstrated that fear of death is associated with stronger negative attitudes toward BPD patients, after controlling for attitudes toward suicide. Our findings emphasize the importance of psychiatrists׳ awareness to their fear of death as a relevant factor for their emotions toward BPD patients.
August 30, 2015: Psychiatry Research
Chiara De Panfilis, Paolo Riva, Emanuele Preti, Chiara Cabrino, Carlo Marchesi
Increasing evidence suggests that individuals with borderline personality disorder (BPD) might feel rejected even when socially included by others. A psychological mechanism accounting for this response bias could be that objective social inclusion violates BPD patients' underlying implicit needs of "extreme" inclusion. Thus, this study investigated whether, during interpersonal exchanges, BPD patients report more rejection-related negative emotions and less feelings of social connection than controls unless they are faced with conditions of extreme social inclusion...
October 2015: Personality Disorders
Jeannette LeGris, Maggie Toplak, Paul S Links
The affective decision making of 41 recently treated outpatient women with borderline personality disorder (BPD) was compared to 41 healthy controls using the Iowa Gambling Task (IGT). Non-affective executive functions (EF) of working memory, interference control, and motor inhibition were also compared. Associations among affective and non-affective EF were examined. Despite normal range intelligence, Stroop interference, motor inhibition, and working memory, women with BPD made significantly more disadvantageous IGT decisions than controls (Cohen's d = ...
October 2014: Journal of Personality Disorders
Constance Hammen, Julienne E Bower, Steven W Cole
Oxytocin appears to be centrally involved in socioemotional functioning, and is hypothesized to be relevant to the severe disruption in close relationships characteristic of borderline personality pathology. We examined whether a polymorphism of the oxytocin receptor gene (OXTR rs53576) interacts with quality of family functioning to predict borderline personality disorder (BPD) symptomatology in a sample of youth at age 20. A total of 385 youth from a longitudinal study of offspring of depressed or nondepressed mothers who were well characterized with respect to their family conditions and BPD symptomatology provided DNA for genotyping...
April 2015: Journal of Personality Disorders
Cornelia E Schwarze, Dirk H Hellhammer, Verena Stroehle, Klaus Lieb, Arian Mobascher
Borderline personality disorder (BPD) is characterized by a pattern of intense but unstable interpersonal relationships. These interpersonal dysfunctions may originate from impaired bonding and attachment that is determined during early life. Remarkably, it has been reported that the quality of mother-infant relationship is influenced by the feeding mode. Thus, bottle feeding instead of breastfeeding and possible lack of maternal bonding-related behavior may increase the risk for later psychopathology and attachment problems as seen in BPD...
October 2015: Journal of Personality Disorders
Lisa Schilling, Steffen Moritz, Brooke Schneider, Julia Bierbrodt, Matthias Nagel
We aimed to examine the profile of interpersonal attributions in BPD. We hypothesized that patients show more mono-causal and internal attributions than healthy controls. A revised version of the Internal, Personal, Situational and Attributions Questionnaire was assessed in 30 BPD patients and 30 healthy controls. BPD patients and controls differed significantly in their attributional pattern. Patients displayed more mono-causal inferences, that is, they had difficulties considering alternative explanatory factors...
December 2015: Journal of Personality Disorders
Ryan W Carpenter, Phillip K Wood, Timothy J Trull
Borderline personality disorder (BPD) is comorbid with substance use disorders (SUDs). However, most epidemiological work on BPD and SUDs has collapsed nonalcohol substances into a drug use disorder indicator, potentially obscuring patterns of association between BPD and individal SUDs. Using a nationally representative sample (National Epidemiologic Survey on Alcohol and Related Conditions; N = 34,481), the authors examined the association between lifetime BPD and nine lifetime SUDs. First, the authors examined the bivariate association of BPD and each SUD...
June 2016: Journal of Personality Disorders
Jaime L Anderson, Martin Sellbom, Randy A Sansone, Douglas A Songer
The current study evaluated the relative associations of the DSM-5 Section II operationalization of Borderline Personality Disorder (BPD) and dimensional traits included in a diagnosis of BPD in DSM-5 Section III with conceptually relevant external criterion variables. It is important to determine whether or not Section II BPD and constellation of Section III BPD traits have similar positions in the nomological network representing the BPD construct. Moreover, it is important to determine whether or not the trait-based Section III BPD diagnosis is an improvement upon the categorical Section II diagnosis in regard to its associations with external criteria...
April 2016: Journal of Personality Disorders
Alexander J Busch, Steve Balsis, Leslie C Morey, Thomas F Oltmanns
The literature on the prevalence of borderline personality disorder (BPD) across gender reveals multiple trends. A number of studies indicate that women have a higher prevalence. Others indicate no difference, and a few even reveal that men have a higher prevalence. Yet existing studies are plagued by sampling biases, use mainly self-reported information, and tend to report general prevalence of BPD categorically defined. The current investigation attempted to shed new light on this literature by analyzing BPD features dimensionally in a representative epidemiological sample of adults ages 55-64, using both self- and informant-reported perspectives...
June 2016: Journal of Personality Disorders
Justin K Meyer, Leslie C Morey
Research on borderline personality disorder (BPD) has consistently found that those with the disorder often experience volatile interpersonal interactions, and several areas of research have been dedicated to the understanding of the mechanisms behind these interpersonal struggles. One of the most common theories is that the emotional dysregulation that is characteristic of BPD may adversely impact these interpersonal interactions, perhaps through a resulting misperception of emotional states in others. The purpose of the current study was to examine perception of negative affect in those with borderline personality features using a signal detection paradigm, a modified version of the Reading the Mind in the Eyes Task...
August 2015: Personality and Mental Health
Johanna Levallius, Göran Rydén, Claes Norring
Patients with borderline personality disorder have a characteristic and extreme personality associated with psychopathology. The aim was to investigate personality change in relation to suicidality following treatment. 21 patients were assessed before and after psychotherapy on personality (NEO PI-R) and suicidality (SUAS). At follow-up, Neuroticism and Conscientiousness normalized along with six lower-order facets; Depression, Impulsiveness, Competence, Achievement Striving, Self-Discipline and Deliberation...
August 30, 2015: Psychiatry Research
K Piotrowicz, A Prejbisz, M Klocek, R Topor-Madry, K Kawecka-Jaszcz, A Januszewicz, K Narkiewicz, T Grodzicki, J Gasowski
OBJECTIVE: To assess blood pressure control rate and its correlates in a Polish nationwide cohort of the community dwelling persons at or above the age of 80 years. DESIGN AND METHOD: As a part of PolFokus study we did a cross-sectional, nationwide survey of 2500 elderly people treated for hypertension for at least one year. In the current analysis we included data of 384 individuals aged 80+. During the survey visit BP was measured at least twice and the mean value was calculated...
June 2015: Journal of Hypertension
Miriam Frankel-Waldheter, Jenny Macfie, Jennifer M Strimpfel, Christopher D Watkins
Several theories propose a relationship between deficits in autonomy and relatedness and the development of borderline personality disorder (BPD). Empirical work supports relationships between maternal BPD and adolescent symptomatology, as well as between maternal autonomy and relatedness and adolescent symptomatology. However, no study has examined how individuals with BPD differ from normative comparisons on autonomy and relatedness, or whether mothers' BPD mediates the relationship between their autonomy and relatedness and their adolescents' symptomatology...
April 2015: Personality Disorders
2015-06-13 23:51:55
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