Robert A Ganz, Jeffrey H Peters, Santiago Horgan, Willem A Bemelman, Christy M Dunst, Steven A Edmundowicz, John C Lipham, James D Luketich, W Scott Melvin, Brant K Oelschlager, Steven C Schlack-Haerer, C Daniel Smith, Christopher C Smith, Dan Dunn, Paul A Taiganides
BACKGROUND: Patients with gastroesophageal reflux disease who have a partial response to proton-pump inhibitors often seek alternative therapy. We evaluated the safety and effectiveness of a new magnetic device to augment the lower esophageal sphincter. METHODS: We prospectively assessed 100 patients with gastroesophageal reflux disease before and after sphincter augmentation. The study did not include a concurrent control group. The primary outcome measure was normalization of esophageal acid exposure or a 50% or greater reduction in exposure at 1 year...
February 21, 2013: New England Journal of Medicine