Morcos Awad, Lawrence S C Czer, Camelia Soliman, James Mirocha, Andrea Ruzza, Joshua Pinzas, Kelsey Rihbany, David Chang, Jaime Moriguchi, Danny Ramzy, Fardad Esmailian, Jon Kobashigawa, Francisco Arabia
Polymorphisms for VKORC1 and CYP2C9 are associated with increased warfarin sensitivity. The prevalence of these polymorphisms in patients with mechanical circulatory support (MCS) is unknown. Polymorphisms for VKORC1 and CYP2C9 were determined in 65 patients undergoing MCS surgery. Postoperative warfarin dose, international normalized ratio (INR), and bleeding events were measured until discharge, 6 months, or composite end point (in-hospital MCS recovery, heart transplant, or death). A total of 67.7% (44/65) had at least one polymorphism: VKORC1 (44...
July 2015: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs