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JOURNAL ARTICLE
Emmanuel Curis, Vincent Pestre, Vincent Jullien, Luc Eyrolle, Denis Archambeau, Philippe Morand, Laure Gatin, Matthieu Karoubi, Nicolas Pinar, Valérie Dumaine, Jean-Claude Nguyen Van, Antoine Babinet, Philippe Anract, Dominique Salmon
PURPOSE: Clindamycin, a lincosamide antibiotic with a good penetration into bone, is widely used for treating bone and joint infections by Gram-positive pathogens. To be active against Staphylococcus spp, its concentration at the infection site, C, must be higher than 2× the minimal inhibitory concentration (MIC). The aims of the work were to study the determinants of plasma clindamycin trough concentration, C min, especially the effect of co-treatment with rifampicin, and the consequences on clinical outcome...
August 2015: Infection
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