Petra Seibold, Sabine Behrens, Peter Schmezer, Irmgard Helmbold, Gillian Barnett, Charlotte Coles, John Yarnold, Christopher J Talbot, Takashi Imai, David Azria, C Anne Koch, Alison M Dunning, Neil Burnet, Judith M Bliss, R Paul Symonds, Tim Rattay, Tomo Suga, Sarah L Kerns, Celine Bourgier, Katherine A Vallis, Marie-Luise Sautter-Bihl, Johannes Claßen, Juergen Debus, Thomas Schnabel, Barry S Rosenstein, Frederik Wenz, Catharine M West, Odilia Popanda, Jenny Chang-Claude
PURPOSE: To identify single-nucleotide polymorphisms (SNPs) in oxidative stress-related genes associated with risk of late toxicities in breast cancer patients receiving radiation therapy. METHODS AND MATERIALS: Using a 2-stage design, 305 SNPs in 59 candidate genes were investigated in the discovery phase in 753 breast cancer patients from 2 prospective cohorts from Germany. The 10 most promising SNPs in 4 genes were evaluated in the replication phase in up to 1883 breast cancer patients from 6 cohorts identified through the Radiogenomics Consortium...
August 1, 2015: International Journal of Radiation Oncology, Biology, Physics