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CKD Biomarkers

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339 papers 25 to 100 followers
By Isabel Acosta-Ochoa Nephrology senior staff. Valladolid. Spain
Aline Martin
PURPOSE OF REVIEW: Chronic kidney disease (CKD) is a condition associated with bone disease and fibroblast growth factor 23 (FGF23) excess that contributes to cardiovascular mortality. Dentin matrix protein 1 (DMP1) is an established regulator of bone mineralization and FGF23 production in osteocytes. To date, DMP1 function has mainly been studied in the context of hereditary hypophosphatemic rickets diseases. This review describes the role of DMP1 as a potential strong candidate to prevent bone disorders, FGF23 elevation and associated cardiac outcomes in CKD...
May 16, 2019: Current Opinion in Nephrology and Hypertension
Mustafa M Sinna, Faris Mn Altaf, Osama F Mosa
BACKGROUND: Acute kidney injury (AKI) has a high global incidence with observable complications in critically ill patients. Long-term disease and medication complexity contribute to devastating chronic kidney disease (CKD) and diminish quality of life. Establishing new biomarkers would guide patient care and facilitate novel therapeutics development. METHODS: Serum and urinary levels of creatinine, CysC, and NGAL were estimated in 86 renal patients and compared with healthy controls for AKI and CKD categorization...
May 15, 2019: Current Pharmaceutical Design
Stella Bernardi, Rebecca Voltan, Erika Rimondi, Elisabetta Melloni, Daniela Milani, Carlo Cervellati, Donato Gemmati, Claudio Celeghini, Paola Secchiero, Giorgio Zauli, Veronica Tisato
Ligands and receptors of the tumor necrosis factor (TNF) superfamily regulate immune responses and homeostatic functions with potential diagnostic and therapeutic implications. Kidney disease represents a global public health problem, whose prevalence is rising worldwide, due to the aging of the population and the increasing prevalence of diabetes, hypertension, obesity, and immune disorders. In addition, chronic kidney disease is an independent risk factor for the development of cardiovascular disease, which further increases kidney-related morbidity and mortality...
May 31, 2019: Clinical Science (1979-)
Ai-Hua Zhang, Wei-Kang Guo, Ling Yu, Wen-Hu Liu
BACKGROUND: Cardiovascular disease is the leading cause of morbidity and mortality in maintenance hemodialysis (MHD) patients. Uremic cardiomyopathy, characterized by myocardial hypertrophy and fibrosis, has a significant contribution to these adverse cardiac outcomes. The protective effect of soluble Klotho (s-Klotho) on myocardial damage was demonstrated in in vitro and animal experiments. However, data from MHD patients is limited. The present study was designed to identify potential correlations between echocardiographic parameters and serum s-Klotho levels in MHD patients...
May 10, 2019: Kidney & Blood Pressure Research
Xiaofang Tang, Jing You, Di Liu, Ming Xia, Liyu He, Hong Liu
BACKGROUND/AIMS: Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Microalbuminuria (MA) is widely used to predict early progressive renal function decline (ERFD) of DN in type 2 diabetes mellitus (T2D) patients, but the sensitivity and specificity of MA have been questioned. Here, we determined the urine metabolites differences between T2D patients with MA who maintained stable renal function and those who progressed to ERFD in order to identify specific biomarkers of the progression of renal dysfunction...
May 9, 2019: Kidney & Blood Pressure Research
M Zulkarnain Bidin, Anim Md Shah, J Stanslas, Christopher Thiam Seong Lim
INTRODUCTION: Chronic kidney disease (CKD) is a silent disease. Most CKD patients are unaware of their condition during the early stages of the disease which poses a challenge for healthcare professionals to institute treatment or start prevention. The trouble with the diagnosis of CKD is that in most parts of the world, it is still diagnosed based on measurements of serum creatinine and corresponding calculations of eGFR. There are controversies with the current staging system, especially in the methodology to diagnose and prognosticate CKD...
April 19, 2019: Clinica Chimica Acta; International Journal of Clinical Chemistry
Alejandra Droguett, Graciela Valderrama, María E Burgos, Daniel Carpio, Constanza Saka, Jesús Egido, Marta Ruiz-Ortega, Sergio Mezzano
Gremlin renal overexpression has been reported in diabetic nephropathy, pauci-immune crescentic glomerulonephritis and chronic allograft nephropathy and has been implicated in the pathophysiology of the progression of renal damage. However, it is unknown whether urinary Gremlin can be associated with renal functional status, renal biopsy findings and outcome. To examine these associations we studied 20 patients with ANCA+ renal vasculitis and very high urinary Gremlin (354 ± 76 ug/gCr), 86 patients with other glomerular diseases and moderately elevated urinary Gremlin (83 ± 14 ug/gCr) and 11 healthy controls (urinary Gremlin 11...
May 3, 2019: Scientific Reports
Thomas J Velenosi, Benjamin K A Thomson, Nicholas C Tonial, Adrien A E RaoPeters, Megan A Mio, Gilles A Lajoie, Amit X Garg, Andrew A House, Bradley L Urquhart
The diagnosis and prognosis of chronic kidney disease (CKD) currently relies on very few circulating small molecules, which can vary by factors unrelated to kidney function. In end-stage renal disease (ESRD), these same small molecules are used to determine dialysis dose and dialytic clearance. Therefore, we aimed to identify novel plasma biomarkers to estimate kidney function in CKD and dialytic clearance in ESRD. Untargeted metabolomics was performed on plasma samples from patients with a single kidney, non-dialysis CKD, ESRD and healthy controls...
May 2, 2019: Scientific Reports
Darren P Wallace
Periostin is a matricellular protein that is expressed in several tissues during embryonic development; however, its expression in adults is mostly restricted to collagen-rich connective tissues. Periostin is expressed only briefly during kidney development, but it is not normally detected in the adult kidney. Recent evidence has revealed that periostin is aberrantly expressed in several forms of chronic kidney disease (CKD), and that its expression correlates with the degree of interstitial fibrosis and the decline in renal function...
2019: Advances in Experimental Medicine and Biology
Cynthia Van der Hauwaert, François Glowacki, Nicolas Pottier, Christelle Cauffiez
Fibrosis, or tissue scarring, is defined as the excessive, persistent and destructive accumulation of extracellular matrix components in response to chronic tissue injury. Renal fibrosis represents the final stage of most chronic kidney diseases and contributes to the progressive and irreversible decline in kidney function. Limited therapeutic options are available and the molecular mechanisms governing the renal fibrosis process are complex and remain poorly understood. Recently, the role of non-coding RNAs, and in particular microRNAs (miRNAs), has been described in kidney fibrosis...
April 23, 2019: International Journal of Molecular Sciences
Drew Watson, Joshua Y C Yang, Reuben D Sarwal, Tara K Sigdel, Juliane M Liberto, Izabella Damm, Victoria Louie, Shristi Sigdel, Devon Livingstone, Katherine Soh, Arjun Chakraborty, Michael Liang, Pei-Chen Lin, Minnie M Sarwal
The current standard of care measures for kidney function, proteinuria, and serum creatinine (SCr) are poor predictors of early-stage kidney disease. Measures that can detect chronic kidney disease in its earlier stages are needed to enable therapeutic intervention and reduce adverse outcomes of chronic kidney disease. We have developed the Kidney Injury Test (KIT) and a novel KIT Score based on the composite measurement and validation of multiple biomarkers across a unique set of 397 urine samples. The test is performed on urine samples that require no processing at the site of collection and without target sequencing or amplification...
April 12, 2019: Journal of Clinical Medicine
Monika A Niewczas, Meda E Pavkov, Jan Skupien, Adam Smiles, Zaipul I Md Dom, Jonathan M Wilson, Jihwan Park, Viji Nair, Andrew Schlafly, Pierre-Jean Saulnier, Eiichiro Satake, Christopher A Simeone, Hetal Shah, Chengxiang Qiu, Helen C Looker, Paolo Fiorina, Carl F Ware, Jennifer K Sun, Alessandro Doria, Matthias Kretzler, Katalin Susztak, Kevin L Duffin, Robert G Nelson, Andrzej S Krolewski
Chronic inflammation is postulated to be involved in the development of end-stage renal disease in diabetes, but which specific circulating inflammatory proteins contribute to this risk remain unknown. To study this, we examined 194 circulating inflammatory proteins in subjects from three independent cohorts with type 1 and type 2 diabetes. In each cohort, we identified an extremely robust kidney risk inflammatory signature (KRIS), consisting of 17 proteins enriched in tumor necrosis factor-receptor superfamily members, that was associated with a 10-year risk of end-stage renal disease...
April 22, 2019: Nature Medicine
Karolis Azukaitis, Wenjun Ju, Marietta Kirchner, Viji Nair, Michelle Smith, Zhiyin Fang, Daniela Thurn-Valsassina, Aysun Bayazit, Anna Niemirska, Nur Canpolat, Ipek Kaplan Bulut, Fatos Yalcinkaya, Dusan Paripovic, Jerome Harambat, Nilgun Cakar, Harika Alpay, Francesca Lugani, Francesca Mencarelli, Mahmut Civilibal, Hakan Erdogan, Jutta Gellermann, Enrico Vidal, Yilmaz Tabel, Charlotte Gimpel, Pelin Ertan, Onder Yavascan, Anette Melk, Uwe Querfeld, Elke Wühl, Matthias Kretzler, Franz Schaefer
Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6-17 years with baseline estimated glomerular filtration rate (eGFR) of 10-60 ml/min/1...
March 20, 2019: Kidney International
Katerina Damianaki, Joao Miguel Lourenco, Philippe Braconnier, Jean-Pierre Ghobril, Olivier Devuyst, Michel Burnier, Sebastien Lenglet, Marc Augsburger, Aurelien Thomas, Menno Pruijm
BACKGROUND: Zinc deficiency is commonly encountered in chronic kidney disease (CKD). The aims of this study were to assess whether zinc deficiency was related to increased renal excretion of zinc and to the progression of CKD. METHODS: Plasma and 24-h urinary zinc levels, urinary electrolytes and uromodulin were measured in 108 CKD patients and 81 individuals without CKD. Serum creatinine values were collected for 3 years to calculate the yearly change in estimated glomerular filtration rate (eGFR)...
April 21, 2019: Nephrology, Dialysis, Transplantation
Junlin Zhang, Yiting Wang, Rui Zhang, Hanyu Li, Qianqian Han, Yucheng Wu, Shanshan Wang, Ruikun Guo, Tingli Wang, Li Li, Fang Liu
AIMS: Heavy proteinuria caused by non-diabetic renal disease (NDRD) is common in type 2 diabetes mellitus (T2DM). The aim of this study was to investigate specific predictors for NDRD in addition to traditional indicators in T2DM. METHODS: A total of 341 patients with T2DM who underwent renal biopsy were retrospectively included. Eligible patients were divided into a nephrotic-range group (n = 194) and a non-nephrotic-range group (n = 147) based on proteinuria level...
April 19, 2019: Acta Diabetologica
Aml Gaber Mohammed Mohammed, Heba S Gafar, Abeer A Elmalah, Marwa Elhady, Heba Mohamed Abd Elgalil, Eman Saad Mohamed Bayoumy
INTRODUCTION: Myocardial dysfunction is a leading cause of mortality in chronic kidney disease (CKD) children specially those on regular hemodialysis. Cardiac biomarkers play a key role for early detection of myocardial injury. We aim to clarify the prognostic role of circulating cardiac biomarkers, heart type fatty acid binding protein (H-FABP) and pregnancy associated plasma protein-A (PAPP-A) in CKD children on regular hemodialysis. MATERIAL AND METHODS: This is a prospective case control study over 2 years duration...
March 2019: Iranian Journal of Kidney Diseases
Marta Kordalewska, Szymon Macioszek, Renata Wawrzyniak, Małgorzata Sikorska-Wiśniewska, Tomasz Śledziński, Michał Chmielewski, Adriana Mika, Michał J Markuszewski
Changes in metabolites composition can reflect currently present pathological processes in a living organism and constitute a basis for diagnosis and treatment improvements. Thus, the multiplatform metabolomics approach was applied for the investigation of molecular mechanisms of chronic kidney disease (CKD) progression. The high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS) and gas chromatography coupled with triple quadrupole mass spectrometry (GC-QqQ/MS) serum metabolic fingerprinting followed by uni- and multivariate statistical analysis was carried out to determine metabolic pattern differentiating CKD patients and healthy controls...
June 1, 2019: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Omnia Safwat El-Deeb, Marwa Mohamed Atef, Yasser Mostafa Hafez
BACKGROUND: Chronic kidney disease (CKD) signifies a frequently life-threatening condition influencing kidney structure and function. Despite its irrefutable importance, its exact pathogenesis is not completely clarified. However, CKD is known to be associated with accumulated uremic toxins/metabolites, interstitial fibrosis, and systemic inflammation. So we aimed to investigate the role of microbiota-dependent metabolite trimethylamine N-oxide (TMAO), transforming growth factor β (TGFβ)/SMAD signaling, and inflammasome activation in CKD pathogenesis through its different stages...
April 19, 2019: Journal of Cellular Biochemistry
Deepali Junnarkar Roy, Shrikant Digambarrao Pande, Zhong Hong Liew, Debajyoti Roy
Introduction: It is not uncommon for patients without preceding history of kidney disease to present to the Emergency department with renal failure. The absence of prior medical records or renal imaging presents a diagnostic challenge. Elevated parathyroid hormone levels or echogenic contracted kidneys on ultrasound are known to point to a diagnosis of chronic kidney disease. The literature in this regard is surprisingly limited. The objective of this study is to assess the role of intact parathyroid (iPTH) blood level and bedside ultrasound in differentiating acute kidney injury from chronic kidney disease...
2019: Emergency Medicine International
Krishnamurthy P Gudehithlu, Peter Hart, Amit Joshi, Ignacio Garcia-Gomez, David J Cimbaluk, George Dunea, Jose A L Arruda, Ashok K Singh
BACKGROUND: Previously we found that kidney tissue and urinary exosomes from patients of diabetic kidney disease showed high levels of ceruloplasmin (CP). Because CP is an acute-phase protein of kidney origin, it could be an early marker of many other kidney diseases. To investigate this hypothesis, we first measured urine exosomal and kidney expression of CP in non-diabetic chronic kidney disease (CKD) patients (membranous nephropathy, focal segmental glomerulosclerosis, lupus nephritis and IgA nephropathy) followed by a longitudinal study in rat passive Heymann nephritis (PHN), a model of human membranous nephropathy...
April 6, 2019: Clinical and Experimental Nephrology
2019-04-09 06:22:13
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