Yan Sun, Li-Yan Zhao, Gui-Bin Wang, Wei-Hua Yue, Yong He, Ni Shu, Qi-Xiang Lin, Fan Wang, Jia-Li Li, Na Chen, Hui-Min Wang, Thomas R Kosten, Jia-Jia Feng, Jun Wang, Yu-De Tang, Shu-Xue Liu, Gui-Fa Deng, Gan-Huan Diao, Yun-Long Tan, Hong-Bin Han, Lu Lin, Jie Shi
Drug addiction shares common neurobiological pathways and risk genes with other psychiatric diseases, including psychosis. One of the commonly identified risk genes associated with broad psychosis has been ZNF804A. We sought to test whether psychosis risk variants in ZNF804A increase the risk of heroin addiction by modulating neurocognitive performance and gray matter volume (GMV) in heroin addiction. Using case-control genetic analysis, we compared the distribution of ZNF804A variants (genotype and haplotype) in 1035 heroin abusers and 2887 healthy subjects...
May 2016: Addiction Biology