Giuseppe D'Agostino, Claudia Cristiano, David J Lyons, Rita Citraro, Emilio Russo, Carmen Avagliano, Roberto Russo, Giuseppina Mattace Raso, Rosaria Meli, Giovambattista De Sarro, Lora K Heisler, Antonio Calignano
BACKGROUND/OBJECTIVES: Nuclear peroxisome proliferator activated receptor-α (PPAR-α) plays a fundamental role in the regulation of lipid homeostasis and is the target of medications used to treat dyslipidemia. However, little is known about the role of PPAR-α in mouse behavior. METHODS: To investigate the function of Ppar-α in cognitive functions, a behavioral phenotype analysis of mice with a targeted genetic disruption of Ppar-α was performed in combination with neuroanatomical, biochemical and pharmacological manipulations...
July 2015: Molecular Metabolism