Heike Weber, Sarah Kittel-Schneider, Julia Heupel, Lena Weißflog, Lindsey Kent, Florian Freudenberg, Aet Alttoa, Antonia Post, Sabine Herterich, Jan Haavik, Anne Halmøy, Ole B Fasmer, Elisabeth T Landaas, Stefan Johansson, Bru Cormand, Marta Ribasés, Cristina Sánchez-Mora, Josep Antoni Ramos-Quiroga, Barbara Franke, Klaus-Peter Lesch, Andreas Reif
Attention deficit/ hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder featuring complex genetics with common and rare variants contributing to disease risk. In a high proportion of cases, ADHD does not remit during adolescence but persists into adulthood. Several studies suggest that NOS1, encoding nitric oxide synthase I, producing the gaseous neurotransmitter NO, is a candidate gene for (adult) ADHD. We here extended our analysis by increasing the original sample, adding two further samples from Norway and Spain, and conducted subgroup and co-morbidity analysis...
September 2015: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics