collection
https://read.qxmd.com/read/26097601/whether-alzheimer-s-diseases-related-genes-also-differently-express-in-the-hippocampus-of-ts65dn-mice
#21
JOURNAL ARTICLE
Bin Zhang, Qiuwei Wang, Tingting Miao, Bin Yu, Pei Yuan, Jing Kong, Beiyi Lu
BACKGROUND: Down syndrome is a condition which extra genetic material causes delays in child development, both mentally and physically. Strengthening the study of the neural defects of DS is of great significance. METHODS: Ts65Dn mice were used in this study. We removed the brain and isolated their hippocampus. We customized 54 genes in one PCR arrays, included some important genes related to Alzheimer's disease. The expression of genes were detected by RT-PCR. RESULTS: PCR arrays contained 54 genes related to Alzheimer's disease...
2015: International Journal of Clinical and Experimental Pathology
https://read.qxmd.com/read/26097763/oxidative-stress-a-phenotypic-hallmark-of-fanconi-anemia-and-down-syndrome-the-effect-of-antioxidants
#22
JOURNAL ARTICLE
H T El-Bassyouni, H H Afifi, M M Eid, R M Kamal, H H El-Gebali, Gsm El-Saeed, M M Thomas, S A Abdel-Maksoud
BACKGROUND: Oxidative stress plays a major role in the pathogenesis of leukemia-prone diseases such as Fanconi anemia (FA) and Down syndrome (DS). AIM: To explore the oxidative stress state in children with DS and FA by estimating the levels of antioxidants (e.g., malondialdehyde [MDA], total antioxidant capacity, and superoxide dismutase [SOD] activity) and DNA damage, and to evaluate of the effect of antioxidant treatment on these patients. SUBJECTS AND METHODS: The study included 32 children clinically diagnosed with (15 patients) and FA (17 patients) in addition to 17 controls matched for age and sex...
May 2015: Annals of Medical and Health Sciences Research
https://read.qxmd.com/read/26103884/down-syndrome-individuals-with-alzheimer-s-disease-have-a-distinct-neuroinflammatory-phenotype-compared-to-sporadic-alzheimer-s-disease
#23
JOURNAL ARTICLE
Donna M Wilcock, Jennifer Hurban, Alex M Helman, Tiffany L Sudduth, Katie L McCarty, Tina L Beckett, Joshua C Ferrell, M Paul Murphy, Erin L Abner, Frederick A Schmitt, Elizabeth Head
Down syndrome (DS) is the most common genetic cause of intellectual disability and is primarily caused by the triplication of chromosome 21. The overexpression of amyloid precursor protein gene may be sufficient to drive Alzheimer's disease (AD) neuropathology that is observed in virtually all individuals with DS by the age of 40 years. There is relatively little information about inflammation in the DS brain and how the genetics of DS may alter inflammatory responses and modify the course of AD pathogenesis in this disorder...
September 2015: Neurobiology of Aging
https://read.qxmd.com/read/26105013/sleep-profiles-in-children-with-down-syndrome
#24
JOURNAL ARTICLE
Julia L Bassell, Han Phan, Roberta Leu, Rebecca Kronk, Jeannie Visootsak
Down syndrome (DS) is the most common genetic cause of intellectual disability and results from an extra chromosome 21 (Trisomy 21). Sleep issues and/or obstructive sleep apnea (OSA) are assumed to be part of the DS phenotype with a high prevalence but are often under recognized. This cross-sectional study of children with DS examines the caregiver-reported sleep behaviors of 108 children with DS, ranging in age from 1.50 to 13.40 years (mean = 5.18 years) utilizing a standardized assessment tool, the Children's Sleep Habit Questionnaire (CSHQ)...
August 2015: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/26107323/diagnosing-dementia-in-adults-with-down-s-syndrome
#25
JOURNAL ARTICLE
Vee P Prasher, Niyati Sachdeva, Nick Tarrant
Individuals with Down's syndrome (DS) are living longer and many will survive into their fifth or sixth decade of life. Among the DS population, the prevalence of dementia in Alzheimer's disease increases from 9.4% in age group 30-39 years to 54.5% age group 60-69 years. The psychopathology of dementia in Alzheimer's disease is similar to that seen in the general population although differences are apparent due to the underlying intellectual disability in DS and on the reliance on collateral information from informants...
2015: Neurodegenerative Disease Management
https://read.qxmd.com/read/26111164/self-organizing-feature-maps-identify-proteins-critical-to-learning-in-a-mouse-model-of-down-syndrome
#26
JOURNAL ARTICLE
Clara Higuera, Katheleen J Gardiner, Krzysztof J Cios
Down syndrome (DS) is a chromosomal abnormality (trisomy of human chromosome 21) associated with intellectual disability and affecting approximately one in 1000 live births worldwide. The overexpression of genes encoded by the extra copy of a normal chromosome in DS is believed to be sufficient to perturb normal pathways and normal responses to stimulation, causing learning and memory deficits. In this work, we have designed a strategy based on the unsupervised clustering method, Self Organizing Maps (SOM), to identify biologically important differences in protein levels in mice exposed to context fear conditioning (CFC)...
2015: PloS One
https://read.qxmd.com/read/26025226/clinical-profile-and-main-comorbidities-of-spanish-adults-with-down-syndrome
#27
JOURNAL ARTICLE
Diego Real de Asua, Miriam Quero, Fernando Moldenhauer, Carmen Suarez
BACKGROUND: The life expectancy of adults with Down syndrome (DS) has significantly increased in the last decades. We aim to describe the main demographic and clinical characteristics of a cohort of adults with DS, and analyse their differences according to age and gender groups. METHODS: Cross-sectional study of 144 adults with DS from the outpatient clinic of a tertiary care hospital in Madrid, Spain, recruited between February 2012 and March 2013. Demographic data (age, gender, living situation, caregivers, and working situation), clinical conditions, prior medications, and laboratory data were measured and compared between groups...
July 2015: European Journal of Internal Medicine
1
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.