Nicole Schupf, Annie Lee, Naeun Park, Lam-Ha Dang, Deborah Pang, Alexander Yale, David Kyung-Taek Oh, Sharon J Krinsky-McHale, Edmund C Jenkins, José A Luchsinger, Warren B Zigman, Wayne Silverman, Benjamin Tycko, Sergey Kisselev, Lorraine Clark, Joseph H Lee
We examined the contribution of candidates genes for Alzheimer's disease (AD) to individual differences in levels of beta amyloid peptides in adults with Down syndrom, a population at high risk for AD. Participants were 254 non-demented adults with Down syndrome, 30-78 years of age. Genomic deoxyribonucleic acid was genotyped using an Illumina GoldenGate custom array. We used linear regression to examine differences in levels of Aβ peptides associated with the number of risk alleles, adjusting for age, sex, level of intellectual disability, race and/or ethnicity, and the presence of the APOE ε4 allele...
October 2015: Neurobiology of Aging