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115 papers 0 to 25 followers
Clayton C Petro, Ivy N Haskins, Arielle J Perez, Luciano Tastaldi, Andrew T Strong, Ramona N Ilie, Chao Tu, David M Krpata, Ajita S Prabhu, Bijan Eghtesad, Michael J Rosen
BACKGROUND: Elective hernia repairs in chronic liver disease (CLD) patients are often avoided due to the fear of hepatic decompensation and mortality, leaving the patient susceptible to an emergent presentation. METHODS: CLD patients undergoing ventral or inguinal hernia repair in emergent and non-emergent settings at our institution (2001-2015) were analyzed. Predictors of 30-day morbidity and mortality (M&M) were determined using univariate analysis and multivariate logistic regression...
January 2019: American Journal of Surgery
Brandon R Hood, Mark E Cowen, Huiyong T Zheng, Richard E Hughes, Bonita Singal, Brian R Hallstrom
Importance: There has been significant debate in the surgical and medical communities regarding the appropriateness of using aspirin alone for venous thromboembolism (VTE) prophylaxis following total knee arthroplasty (TKA). Objective: To determine the acceptability of aspirin alone vs anticoagulant prophylaxis for reducing the risk of postoperative VTE in patients undergoing TKA. Design, Setting, and Participants: Noninferiority study of a retrospective cohort of TKA cases submitted to the Michigan Arthroplasty Registry Collaborative Quality Initiative at 29 member hospitals, ranging from small community hospitals to large academic and nonacademic medical centers in Michigan...
October 17, 2018: JAMA Surgery
A Shiraishi, S Kushimoto, Y Otomo, H Matsui, A Hagiwara, K Murata
BACKGROUND: A reduction in mortality with the early use of tranexamic acid has been demonstrated in severely injured patients who are bleeding. However, the modest treatment effect with no reduction in blood transfusion has raised concerns. The aim of the present study was to estimate the effectiveness of regular use of tranexamic acid in severely injured patients. METHODS: This multicentre observational study used retrospectively collected data from consecutive injured patients (Injury Severity Score at least 16) treated in 15 Japanese academic institutions in 2012...
May 2017: British Journal of Surgery
Vanessa W Stevens, Richard E Nelson, Elyse M Schwab-Daugherty, Karim Khader, Makoto M Jones, Kevin A Brown, Tom Greene, Lindsay D Croft, Melinda Neuhauser, Peter Glassman, Matthew Bidwell Goetz, Matthew H Samore, Michael A Rubin
Importance: Metronidazole hydrochloride has historically been considered first-line therapy for patients with mild to moderate Clostridium difficile infection (CDI) but is inferior to vancomycin hydrochloride for clinical cure. The choice of therapy may likewise have substantial consequences on other downstream outcomes, such as recurrence and mortality, although these secondary outcomes have been less studied. Objective: To evaluate the risk of recurrence and all-cause 30-day mortality among patients receiving metronidazole or vancomycin for the treatment of mild to moderate and severe CDI...
April 1, 2017: JAMA Internal Medicine
Peter Emanuelsson, Ulf Gunnarsson, Ursula Dahlstrand, Karin Strigård, Birgit Stark
BACKGROUND: The primary aim of this prospective, randomized, clinical, 2-armed trial was to evaluate the risk for recurrence using 2 different operative techniques for repair of abdominal rectus diastasis. Secondary aims were comparison of pain, abdominal muscle strength, and quality of life and to compare those outcomes to a control group receiving physical training only. METHODS: Eighty-six patients were enrolled. Twenty-nine patients were allocated to retromuscular polypropylene mesh and 27 to double-row plication with Quill technology...
November 2016: Surgery
Zhaohui Liu, Zhengping Wang, Guangwei Han, Lina Huang, Jihong Jiang, Shitong Li
BACKGROUND: High mobility group box-1 (HMGB1) acts as an inflammatory mediator and has been implicated in pathophysiological damage of vascular inflammatory diseases. Ketamine, an anesthetic agent with sedative and analgesic properties, has been shown to have potent anti-inflammatory effects in a variety of models of systemic inflammation. However, the effects of ketamine on HMGB1-mediated proinflammatory responses have not been fully investigated. In the present study, we investigated the effects of ketamine on HMGB1-activated endothelial cells and explored the underlying mechanisms...
February 2016: Journal of Surgical Research
Thuy B Tran, David J Worhunsky, Malcolm H Squires, Linda X Jin, Gaya Spolverato, Konstantinos I Votanopoulos, Clifford S Cho, Sharon M Weber, Carl Schmidt, Edward A Levine, Mark Bloomston, Ryan C Fields, Timothy M Pawlik, Shishir K Maithel, Jeffrey A Norton, George A Poultsides
BACKGROUND: Although the extent of resection frequently dictates the method of reconstruction following distal subtotal gastrectomy, it is unclear whether Roux-en-Y gastrojejunostomy compared with Billroth II gastrojejunostomy is associated with superior perioperative outcomes. METHODS: Patients who underwent resection for gastric cancer with Roux-en-Y or Billroth II reconstruction between 2000 and 2012 in seven academic institutions (US Gastric Cancer Collaborative) were identified...
July 2016: Gastric Cancer
Mohammad Khreiss, Mazen Zenati, Amber Clifford, Kenneth K Lee, Melissa E Hogg, Adam Slivka, Jennifer Chennat, Andres Gelrud, Herbert J Zeh, Georgios I Papachristou, Amer H Zureikat
INTRODUCTION: Walled-off pancreatic necrosis (WON) is a sequela of acute necrotizing pancreatitis in 15-40% of cases. We sought to compare the outcomes of minimally invasive surgical and endoscopic cyst gastrostomy (CG) and necrosectomy for the management for sterile WON at a tertiary care high-volume pancreas center. METHOD: This is a retrospective review of patients who underwent minimally invasive surgical or endoscopic CG and necrosectomy for clinically sterile WON between 2008 and 2013...
August 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Brian K P Goh, Zhimin Lin, Damien M Y Tan, Choon-Hua Thng, Christopher J L Khor, Tony K H Lim, London L P J Ooi, Alexander Y F Chung
BACKGROUND: International consensus guidelines to guide management of intraductal papillary mucinous neoplasms (IPMN) were revised in Fukuoka and published in 2012. However, despite widespread acceptance of the Fukuoka Consensus Guidelines (FCG), the utility of these guidelines have not been well-validated. This systematic review was performed to evaluate the clinical utility of the FCG. DESIGN: A computerized search of the PubMed and Scopus databases was performed to identify all studies evaluating the utility of the FCG in surgically resected IPMN...
November 2015: Surgery
Mary Maluccio, Anne Covey
Hepatocellular carcinoma (HCC) is one of the few cancers in which a continued increase in incidence has been observed over several years. As such, there has been a focus on safe and accurate diagnosis and the development of treatment algorithms that take into consideration the unique complexities of this patient population. In the past decade, there have been improvements in nonsurgical treatment platforms and better standardization with respect to the diagnosis and patient eligibility for liver transplant...
November 2012: CA: a Cancer Journal for Clinicians
A Andres, G Mentha, R Adam, E Gerstel, O G Skipenko, E Barroso, S Lopez-Ben, C Hubert, P E Majno, C Toso
BACKGROUND: The management of patients with colorectal cancer and simultaneously diagnosed liver and lung metastases (SLLM) remains controversial. METHODS: The LiverMetSurvey registry was interrogated for patients treated between 2000 and 2012 to assess outcomes after resection of SLLM, and the factors associated with survival. SLLM was defined as liver and lung metastases diagnosed 3 months or less apart. Survival was compared between patients with resected isolated liver metastases (group 1, control), those with resected liver and lung metastases (group 2), and patients with resected liver metastases and unresected (or unresectable) lung metastases (group 3)...
May 2015: British Journal of Surgery
Dionissios D Karavias, Dimitrios D Karavias, Ioannis G Chaveles, Stavros K Kakkos, Nicolaos A Katsiakis, Ioannis C Maroulis
BACKGROUND: Postoperative pancreatic fistula (POPF) due to anastomotic leak is often associated with significant morbidity and mortality. The aim of this study was to present an improved anastomotic technique for Whipple operation, which we call "true" duct-to-mucosa anastomosis (DMA)-pancreaticojejunostomy. METHODS: A novel enteric mucosal eversion at the point of the jejunostomy is constructed prior to the anastomosis with the pancreatic duct in order to enhance sealing...
March 2015: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Jingjing L Sherman, Emily W Shi, Nalin E Ranasinghe, Muthu T Sivasankaran, Jake G Prigoff, Celia M Divino
BACKGROUND: In 2009, a study from our institution used retrospective data and multivariate analysis to identify 5 quantitative variables and their cutoffs that have a positive predictive value (PPV) for common bile duct (CBD) stones in gallstone pancreatitis. They also proposed a management protocol based on the scoring system. This prospective study sought to validate that scoring system. METHODS: From October 2009 to August 2013, patients with gallstone pancreatitis were enrolled in the study...
June 2015: Surgery
M Derogar, J Blomberg, O Sadr-Azodi
BACKGROUND: The association between hospital teaching status and mortality after pancreatic resection is not well explored. Although hospital volume is related to short-term mortality, the effect on long-term survival needs investigation, taking into account hospital teaching status and selective referral patterns. METHODS: This was a nationwide retrospective register-based cohort study of patients undergoing pancreatic resection between 1990 and 2010. Follow-up for survival was carried out until 31 December 2011...
April 2015: British Journal of Surgery
Malcolm H Squires, N Volkan Adsay, David M Schuster, Maria C Russell, Kenneth Cardona, Keith A Delman, Joshua H Winer, Deniz Altinel, Juan M Sarmiento, Bassel El-Rayes, Natalyn Hawk, Charles A Staley, Shishir K Maithel, David A Kooby
BACKGROUND: Clinicians may order Octreoscan or positron emission tomography (PET) scan for staging patients with neuroendocrine tumors (NETs). (111)In-Octreoscan (Octreoscan) identifies tumors by radiolabeled targeting of somatostatin receptors, while 18F-fluorodeoxyglucose-positron emission tomography ((18)FDG-PET) measures differential tissue glucose transport. We assessed the sensitivity of both nuclear imaging modalities with pathologic correlation to define the best initial choice for NET staging after standard cross-sectional imaging...
July 2015: Annals of Surgical Oncology
Wesley A Papenfuss, Moshim Kukar, Jacqueline Oxenberg, Kristopher Attwood, Steven Nurkin, Usha Malhotra, Neal W Wilkinson
BACKGROUND: Surgery alone is often inadequate for advanced-stage gastric cancer. Surgical complications may delay adjuvant therapy. Understanding these complications is needed for multidisciplinary planning. MATERIAL AND METHODS: The American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) database was queried for patients who underwent gastrectomy for malignancy (ICD-9 code 151.x) from 2005 to 2010. Thirty-day mortality and morbidity were evaluated...
September 2014: Annals of Surgical Oncology
K Parry, L Haverkamp, R C G Bruijnen, P D Siersema, J P Ruurda, R van Hillegersberg
BACKGROUND: Patients with adenocarcinoma of the gastro-esophageal junction (GEJ) may undergo either esophagectomy or gastrectomy. The aim of this study was to evaluate the outcome of surgical therapy with regard to postoperative outcome and survival in patients with Siewert type II tumors. METHODS: A prospective database of 266 consecutive patients with surgically resectable GEJ adenocarcinomas from 2003 to 2013 was analyzed. The surgical approach was based on preoperative imaging and intraoperative findings...
February 2015: Annals of Surgical Oncology
Kurinchi Selvan Gurusamy, Rahul Koti, Brian R Davidson
BACKGROUND: Laparoscopic cholecystectomy is the main method of treatment of symptomatic gallstones. Drains are used after laparoscopic cholecystectomy to prevent abdominal collections. However, drain use may increase infective complications and delay discharge. OBJECTIVES: The aim is to assess the benefits and harms of routine abdominal drainage in uncomplicated laparoscopic cholecystectomy. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and Science Citation Index Expanded until February 2013...
2013: Cochrane Database of Systematic Reviews
Zubin M Bamboat, Ronald P Dematteo
Despite being the most common sarcoma of the gastrointestinal tract, gastrointestinal stromal tumor (GIST) has been widely recognized as a unique entity for just over a decade. The advent of tyrosine kinase inhibitors has revolutionized the diagnosis and treatment of GIST. Although surgery remains the only chance for cure, multimodal treatment that includes molecular therapy continues to develop. Optimal management of GIST requires careful radiographic, pathologic, medical, and surgical care, emphasizing the need for a multidisciplinary approach...
April 2012: Surgical Oncology Clinics of North America
Siong-Seng Liau, M Saeed Qureshi, Raaj Praseedom, Emmanuel Huguet
INTRODUCTION: Hepatic adenomas (HAs) are benign tumors of the liver, which can be solitary or multiple, and have a definite risk of malignant degeneration. DISCUSSION: The pathogenesis and natural history of this disease entity were previously unknown. Recent research into the molecular pathogenesis of this condition has provided evidence for the malignant transformation of some of these adenomas. In the current article, we discuss the current evidence on the molecular biology underlying malignant transformation of hepatic adenomas and the implications for the surgical management of this disease...
October 2013: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
2015-06-03 00:56:51
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