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Thomas Khoo, Susanna Proudman, Vidya Limaye
INTRODUCTION: Silicone breast implants (SBI) may induce systemic autoimmune disease as part of autoimmune syndrome induced by adjuvants (ASIA). This syndrome bears similarities to fibromyalgia and chronic fatigue syndrome (CFS). We sought to determine whether there are any associations between SBI and depression, fibromyalgia and CFS in a rheumatology clinic population. METHODS: The electronic files of rheumatology clinic patients at the Royal Adelaide Hospital between 2000 and 2017 were searched for patients who had received SBI prior to rheumatological diagnosis...
January 31, 2019: Clinical Rheumatology
Katelyn R Smithling, Emily E Adams-Piper, Alexis M Tran A, Bhumy A Davé, Christine M Chu, Robert C Chan, Danielle D Antosh, Robert E Gutman
OBJECTIVE: The objective of this study is to compare quality of life and success rates of repeat midurethral slings (RMUS) using retropubic (RP) and transobturator (TO) routes. MATERIALS AND METHODS: Multicenter retrospective cohort with prospective follow-up of patients undergoing RMUS from 2003 to 2016. Prospective Urinary Distress Inventory (UDI-6) and Patient Global Impression of Improvement (PGI-I) were collected by phone. Primary outcome was success of repeat sling by approach (RP vs TO), defined as responses of no to UDI-6 number 3 and very much better or much better on PGI-I...
July 11, 2018: Female Pelvic Medicine & Reconstructive Surgery
Giuseppe Alessandro Digesu, Visha Tailor, Mario Preti, Pedro Vieira-Baptista, Tufan Tarcan, Colleen Stockdale, Sherif Mourad
AIMS: Energy-based devices using radiofrequency and laser technologies have gained popularity as therapies for vaginal atrophy, urinary incontinence, and vaginal prolapse. They have been promoted by cosmetic and aesthetic industries for vaginal "laxity" and vaginal "rejuvenation," both of which are undefined conditions and terms. This article aims to review the current available literature and its quality on this emerging technology. METHODS: An international panel of gynaecologists, urogynaecologists, and urologists undertook a review of the available published literature, identifying articles, guidance, and society statements on the use vaginal energy-based devices...
January 29, 2019: Neurourology and Urodynamics
Lucas Mira Gon, Cassio Luis Zanettini Riccetto, Caio Cesar Citatini de Campos, Brunno Raphael Iamashita Voris, Leonardo O Reis, Paulo Cesar Rodrigues Palma
PURPOSE: To evaluate mini-sling long-term results and correlate them to failure predictors. Many studies show comparable results among different single-incision slings developed as an attempt to reduce complications while keeping good results, but there is a lack of evidence about mini-slings outcomes in the long term. METHODS: This prospective, single-center study evaluated 40 patients for long-term outcomes after mini-sling placement. Objective cure was defined as leakage of less than 1 g in 1-hour pad-test and no leakage at Valsalva maneuver...
January 30, 2019: Urologia Internationalis
Ralph Stephan von Bardeleben, Lukas Hobohm, Felix Kreidel, Mir A Ostad, Eberhard Schulz, Stavros Konstantinides, Mareike Lankeit, Ted Feldman, Thomas Münzel, Karsten Keller
AIMS: The number of percutaneous edge-to-edge mitral regurgitation valve repairs with MitraClip® implantation increased during the last years. Published studies showed promising safety outcomes in relatively small cohorts, while results from large samples are sparse. Thus, we aimed to evaluate trends and safety outcomes in the German nationwide inpatient sample. METHODS AND RESULTS: We analyzed data on patients' characteristics and in-hospital safety outcomes for all percutaneous mitral valve repairs in MitraClip® technique in Germany between 2011 and 2015...
January 22, 2019: EuroIntervention
Shelley Potter, Elizabeth J Conroy, Ramsey I Cutress, Paula R Williamson, Lisa Whisker, Steven Thrush, Joanna Skillman, Nicola L P Barnes, Senthurun Mylvaganam, Elisabeth Teasdale, Abhilash Jain, Matthew D Gardiner, Jane M Blazeby, Chris Holcombe
BACKGROUND: Use of biological or synthetic mesh might improve outcomes of immediate implant-based breast reconstruction-breast reconstruction with implants or expanders at the time of mastectomy-but there is a lack of high-quality evidence to support the safety or effectiveness of the technique. We aimed to establish the short-term safety of immediate implant-based breast reconstruction performed with and without mesh, to inform the feasibility of undertaking a future randomised clinical trial comparing different breast reconstruction techniques...
January 9, 2019: Lancet Oncology
A Brinzeu, E Cuny, D Fontaine, P Mertens, P P Luyet, C Van den Abeele, M C Djian
BACKGROUND: Spinal cord stimulation (SCS) is an established therapy for refractory neuropathic pain. To ascertain the balance between treatment benefits and risks, the French National Authority for Health requested a post-market registry for real-world evaluation of the long-term effectiveness and safety of the therapy. METHODS: 402 patients undergoing implantation with a Medtronic SCS device as either a primo-implant (n=264) or replacement implant (n=138) were enrolled across 28 representative sites in France...
December 29, 2018: European Journal of Pain: EJP
Cynthia Yeung, Bachar Hazim, Debra Campbell, Jim Gooding, Shirley Xl Li, Ho Kit Tam, Wilma M Hopman, Sanoj Chacko, Damian P Redfearn, Christopher Simpson, Hoshiar Abdollah, Adrian Baranchuk
PURPOSE: As cardiovascular implantable electronic devices (CIEDs) are increasingly indicated in older patients, and the burden of cancer is rising with the aging population, the management of patients with CIEDs who require radiotherapy (RT) is a timely concern. The objective of the study was to evaluate the management of, and malfunctions in, patients with CIEDs undergoing RT. METHODS: A retrospective study of patients with CIEDs receiving RT at Kingston Health Sciences Center from March 2007-April 2018 was conducted...
January 3, 2019: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
The Lancet Oncology
No abstract text is available yet for this article.
January 2019: Lancet Oncology
Geoffrey S Cohn, Dean Corbett, Abi Tenen, Minas Coroneo, James McAlister, Jennifer P Craig, Trevor Gray, David Kent, Neil Murray, Con Petsoglou, Stephanie N Baba, Edward J Holland
Purpose: We assess the safety and effectiveness of intranasal neurostimulation to promote tear production via the nasolacrimal pathway in subjects with dry eye disease. Methods: A multicenter, randomized, controlled, double-masked pilot study was conducted in adults with dry eye diagnosis and at least one eye with corneal fluorescein staining ≥2 in at least one region or a sum of all regions ≥5 (National Eye Institute grading), basal Schirmer test score ≤10 mm, a cotton-swab stimulated Schirmer score ≥7 mm higher, and an Ocular Surface Disease Index score ≥23...
January 2, 2019: Investigative Ophthalmology & Visual Science
Catherine Gordon, Savanah Gonzales, Michael L Krychman
OBJECTIVE: The treatment of genitourinary syndrome of menopause (GSM) includes prescription hormone therapy, nonhormonal over-the-counter products, and most recently, laser treatment. Although the Food and Drug Administration has cleared fractional carbon dioxide (CO2) laser for a variety of dermatologic and gynecologic indications, lasers have not to date, been approved for use for vulvar/vaginal atrophy, or sexual dysfunction. METHODS: Four case studies that were referred to a tertiary sexual medicine center regarding laser treatment complications for GSM are reported...
January 14, 2019: Menopause: the Journal of the North American Menopause Society
Kathryn M Wagner, Visish M Srinivasan, Aditya Srivatsan, Michael G Z Ghali, Ajith J Thomas, Alejandro Enriquez-Marulanda, Abdulrahman Y Alturki, Christopher S Ogilvy, Maxim Mokin, Anna L Kuhn, Ajit Puri, Ramesh Grandhi, Stephen Chen, Jeremiah Johnson, Peter Kan
OBJECTIVEWith the increasing use of flow diversion as treatment for intracranial aneurysms, there is a concomitant increased vigilance in monitoring complications. The low porosity of flow diverters is concerning when the origins of vessels are covered, whether large circle of Willis branches or critical perforators. In this study, the authors report their experience with flow diverter coverage of the lenticulostriate vessels and evaluate their safety and outcomes.METHODSThe authors retrospectively reviewed 5 institutional databases of all flow diversion cases from August 2012 to June 2018...
January 11, 2019: Journal of Neurosurgery
Katherine Moore, Anand Ganesan, Clementine Labrosciano, William Heddle, Andrew McGavigan, Sadia Hossain, Dennis Horton, Saranya Hariharaputhiran, Isuru Ranasinghe
Background To date, limited population-level studies have examined the impact of sex on the acute complications of cardiac implantable electronic devices ( CIED) , including permanent pacemakers, implantable cardioverter defibrillators, and cardiac resynchronization therapy devices. Methods and Results We studied all patients aged >18 years from 2010 to 2015 who were a resident of Australia or New Zealand, undergoing a new permanent pacemaker, implantable cardioverter defibrillator, or cardiac resynchronization therapy implant...
January 22, 2019: Journal of the American Heart Association
Bjørn Holdø, Margareta Verelst, Rune Svenningsen, Ian Milsom, Finn Egil Skjeldestad
INTRODUCTION: The retropubic tension-free vaginal tape has been the preferred method for primary surgical treatment of stress urinary incontinence and stress dominated mixed urinary incontinence in women for more than 20 years. This study presents long-term safety and efficacy data and assesses risk factors for long-term recurrence. MATERIAL AND METHODS: In a case-series design we assessed a historical cohort of primary surgeries performed with the tension-free vaginal tape procedure in 596 women from 1998 to 2012 with follow-up through 2015...
January 19, 2019: Acta Obstetricia et Gynecologica Scandinavica
Lauryn Samelko, Marco S Caicedo, Joshua Jacobs, Nadim James Hallab
Metal hypersensitivity has been recognized as an adverse biologic reaction that can compromise total joint arthroplasty (TJA) performance. However, the etiology of metal hypersensitivity responses in TJAs remains unclear. Metal implant debris is known to act as a danger signal that drives NLRP3 inflammasome activation. It remains unknown if implant debris induced inflammasome activation regulates T cell lineage in TJA metal hypersensitivity responses. In this study, we show both in vivo and in vitro that the pathogenesis of metal hypersensitivity responses to implant debris are largely dependent on activation of the inflammasome/caspase-1 pathway and subsequent production of IL-17A/F by CD4+ T cells...
2019: PloS One
Deborah S Hess, Gary E Lemack
No abstract text is available yet for this article.
December 20, 2018: European Urology
Ally Murji, Stephanie Scott, Sony Sukhbir Singh, Olga Bougie, Nicholas Leyland, Philippe-Yves Laberge, George A Vilos
OBJECTIVE: This guideline provides guidance to gynaecologists regarding the use of tissue morcellation in gynaecologic surgery. OUTCOMES: Morcellation may be used in gynaecologic surgery to allow removal of large uterine specimens, thus providing women with a minimally invasive surgical option. Adverse oncologic outcomes of tissue morcellation should be mitigated through improved patient selection, preoperative investigations, and novel techniques that minimize tissue dispersion...
January 2019: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Fiona Bach, Simon Hill, Philip Toozs-Hobson
BACKGROUND: Analysing surgical databases utilises "real-life" outcomes rather than highly selected cases from randomised controlled trials. Retropubic midurethral slings are a highly effective surgical treatment for stress urinary incontinence but if modifiable patient characteristics alter outcomes, rendering treatments less effective, patients should be informed and given the opportunity to change. OBJECTIVE: The aim was to evaluate the effect of body mass index on patient reported outcome measures by analysing midurethral slings from the British Society of Urogynaecology database...
December 18, 2018: American Journal of Obstetrics and Gynecology
Alka A Bhide, Vik Khullar, Stephen Swift, Giuseppe A Digesu
INTRODUCTION: The use of lasers in urogynaecology has increased in recent years. Their use has been described in pelvic organ prolapse, urinary incontinence and genito-urinary symptoms of menopause. The aim of this study was to review the published literature on CO2 and erbium:YAG laser use in urogynaecological conditions. METHODS: An extensive search of literature databases (PubMed, EMBASE) was performed for publications (full text and abstracts) written in English up to July 2018...
December 18, 2018: International Urogynecology Journal
2018-12-21 18:58:57
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