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Vitamin C

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6 papers 0 to 25 followers
By Joe Weatherly FM/Hospitalist-CoFounder of QuestioningMedicine and PCRAP contributor.
Ali Sahraian, Ahmad Ghanizadeh, Fereshteh Kazemeini
BACKGROUND: There are some animal studies suggesting the possible role of vitamin C for treating depression. However, the efficacy of vitamin C for treating adult patients with major depressive disorder (MDD) has never been examined. METHODS: This 8-week randomized double-blind placebo-controlled clinical trial included adult patients with major depressive disorder according to DSM-IV diagnostic criteria. Twenty-one patients in the treatment group received citalopram plus vitamin C and the 22 patients in the control group received citalopram plus placebo...
December 2015: Trials
Cindy T McEvoy, Diane Schilling, Nakia Clay, Keith Jackson, Mitzi D Go, Patricia Spitale, Carol Bunten, Maria Leiva, David Gonzales, Julie Hollister-Smith, Manuel Durand, Balz Frei, A Sonia Buist, Dawn Peters, Cynthia D Morris, Eliot R Spindel
IMPORTANCE: Maternal smoking during pregnancy adversely affects offspring lung development, with lifelong decreases in pulmonary function and increased asthma risk. In a primate model, vitamin C blocked some of the in-utero effects of nicotine on lung development and offspring pulmonary function. OBJECTIVE: To determine if newborns of pregnant smokers randomized to receive daily vitamin C would have improved results of pulmonary function tests (PFTs) and decreased wheezing compared with those randomized to placebo...
May 2014: JAMA: the Journal of the American Medical Association
D Montero, G Walther, C D A Stehouwer, A J H M Houben, J A Beckman, A Vinet
Controversy exists among trials assessing whether prolonged antioxidant vitamin supplementation improves endothelial function in type 2 diabetes mellitus (T2DM) subjects. The aim of this study was to systematically review and quantify the effect of antioxidant vitamin supplementation on endothelial function in T2DM subjects. MEDLINE, Cochrane, Scopus and Web of Science were searched up to February 2013 for randomized controlled trials assessing the effect of antioxidant vitamin E and/or C supplementation on endothelial function in T2DM subjects...
February 2014: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
Kathryn C Fitzgerald, √Čilis J O'Reilly, Elinor Fondell, Guido J Falcone, Marjorie L McCullough, Yikyung Park, Laurence N Kolonel, Alberto Ascherio
OBJECTIVE: Prior research has suggested the possible role of oxidative stress in the pathogenesis of amyotrophic lateral sclerosis (ALS). Prospective data examining dietary antioxidants such carotenoids and vitamin C are limited. METHODS: Risk of ALS associated with carotenoid and vitamin C intake was investigated in 5 prospective cohorts: the National Institutes of Health-Association of American Retired Persons Diet and Health Study, the Cancer Prevention Study II Nutrition Cohort, the Multiethnic Cohort, the Health Professionals Follow-up Study (HPFS), and the Nurses Health Study (NHS)...
February 2013: Annals of Neurology
Stephen P Juraschek, Eliseo Guallar, Lawrence J Appel, Edgar R Miller
BACKGROUND: In observational studies, increased vitamin C intake, vitamin C supplementation, and higher blood concentrations of vitamin C are associated with lower blood pressure (BP). However, evidence for blood pressure-lowering effects of vitamin C in clinical trials is inconsistent. OBJECTIVE: The objective was to conduct a systematic review and meta-analysis of clinical trials that examined the effects of vitamin C supplementation on BP. DESIGN: We searched Medline, EMBASE, and Central databases from 1966 to 2011...
May 2012: American Journal of Clinical Nutrition
James M Roberts, Leslie Myatt, Catherine Y Spong, Elizabeth A Thom, John C Hauth, Kenneth J Leveno, Gail D Pearson, Ronald J Wapner, Michael W Varner, John M Thorp, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Marshall W Carpenter, Philip Samuels, Anthony Sciscione, Margaret Harper, Wendy J Smith, George Saade, Yoram Sorokin, Garland B Anderson
BACKGROUND: Oxidative stress has been proposed as a mechanism linking the poor placental perfusion characteristic of preeclampsia with the clinical manifestations of the disorder. We assessed the effects of antioxidant supplementation with vitamins C and E, initiated early in pregnancy, on the risk of serious adverse maternal, fetal, and neonatal outcomes related to pregnancy-associated hypertension. METHODS: We conducted a multicenter, randomized, double-blind trial involving nulliparous women who were at low risk for preeclampsia...
April 8, 2010: New England Journal of Medicine
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