Marija Barbateskovic, Sara R Krauss, Marie O Collet, Nina C Andersen-Ranberg, Ole Mathiesen, Janus C Jakobsen, Anders Perner, Jørn Wetterslev
BACKGROUND: Haloperidol is the most frequently used drug to treat delirium in the critically ill patients. Yet, no systematic review has focussed on the effects of haloperidol in critically ill patients with delirium. METHODS: We conducted a systematic review with meta-analysis and Trial Sequential Analysis of randomized clinical trials (RCTs) assessing the effects of haloperidol vs any intervention on all-cause mortality, serious adverse reactions/events, days alive without delirium, health-related quality of life (HRQoL), cognitive function and delirium severity in critically ill patients with delirium...
February 2020: Acta Anaesthesiologica Scandinavica