Zuzana Kasanova, Dennis Hernaus, Thomas Vaessen, Thérèse van Amelsvoort, Oliver Winz, Alexander Heinzel, Jens Pruessner, Felix M Mottaghy, Dina Collip, Inez Myin-Germeys
Early life stress may have a lasting impact on the developmental programming of the dopamine (DA) system implicated in psychosis. Early adversity could promote resilience by calibrating the prefrontal stress-regulatory dopaminergic neurotransmission to improve the individual's fit with the predicted stressful environment. Aberrant reactivity to such match between proximal and distal environments may, however, enhance psychosis disease risk. We explored the combined effects of childhood adversity and adult stress by exposing 12 unmedicated individuals with a diagnosis of non-affective psychotic disorder (NAPD) and 12 healthy controls (HC) to psychosocial stress during an [18F]fallypride positron emission tomography...
2016: PloS One