Ben J Stenson, William O Tarnow-Mordi, Brian A Darlow, John Simes, Edmund Juszczak, Lisa Askie, Malcolm Battin, Ursula Bowler, Roland Broadbent, Pamela Cairns, Peter Graham Davis, Sanjeev Deshpande, Mark Donoghoe, Lex Doyle, Brian W Fleck, Alpana Ghadge, Wendy Hague, Henry L Halliday, Michael Hewson, Andrew King, Adrienne Kirby, Neil Marlow, Michael Meyer, Colin Morley, Karen Simmer, Win Tin, Stephen P Wardle, Peter Brocklehurst
BACKGROUND: The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that infants had reduced rates of retinopathy of prematurity when lower targets of oxygen saturation were used. METHODS: In three international randomized, controlled trials, we evaluated the effects of targeting an oxygen saturation of 85 to 89%, as compared with a range of 91 to 95%, on disability-free survival at 2 years in infants born before 28 weeks' gestation...
May 30, 2013: New England Journal of Medicine