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Dysrhythmias reviewed

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3 papers 0 to 25 followers
By Arthur Cronwright Aspiring to best practice always
Dan M Roden
Drugs used to treat cardiovascular disease as well as those used in the treatment of multiple other conditions can occasionally produce exaggerated prolongation of the QT interval on the electrocardiogram and the morphologically distinctive polymorphic ventricular tachycardia ('torsades de pointes'). This syndrome of drug-induced long QT syndrome has moved from an interesting academic exercise to become a key element in the development of any new drug entity. The prevailing view, which has driven both clinical care and drug regulation, holds that cardiac repolarization represents a balance between inward currents (primarily through calcium and sodium channels) and outward currents (primarily through rapid and slowed delayed rectifier potassium channels) and that block of the rapid delayed rectifier (IKr ) is the primary mechanism whereby drugs prolong individual action potentials, manifest on the surface electrocardiogram as QT interval prolongation...
May 1, 2016: Journal of Physiology
Nobuhiro Takasugi, Hiroko Goto, Mieko Takasugi, Richard L Verrier, Takashi Kuwahara, Tomoki Kubota, Hiroyuki Toyoshi, Takashi Nakashima, Masanori Kawasaki, Kazuhiko Nishigaki, Shinya Minatoguchi
BACKGROUND: Prevalence of microvolt T-wave alternans (TWA) and the strength of its association with torsade de pointes (TdP) history have not been fully investigated in patients with long QT syndrome (LQTS). METHODS AND RESULTS: Twenty-four-hour continuous 12-lead ECGs were recorded in 10 healthy subjects (5 men; median age, 21.5 years) and 32 patients (13 men; median age, 13 years) with LQTS types 1 (n=18), 2 (n=4), 3 (n=4), and unidentified (n=6). Peak TWA was determined by the Modified Moving Average method...
February 2016: Circulation. Arrhythmia and Electrophysiology
Gerard B Hannibal
No abstract text is available yet for this article.
January 2015: AACN Advanced Critical Care
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