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JOURNAL ARTICLE
T Hellingman, M E de Swart, J J A Joosten, M R Meijerink, J J J de Vries, J W D de Waard, A A van Zweeden, B M Zonderhuis, G Kazemier
BACKGROUND: For patients with colorectal cancer liver metastases (CRLM), local treatment is the only treatment with curative intent. The majority of patients with CRLM are however evaluated in multidisciplinary teams of colorectal cancer specialists often lacking expertise in local treatment of liver tumors. The aim of this study was therefore to assess the value of a dedicated multidisciplinary panel consisting of hepatobiliary surgeons and interventional radiologists for patients suffering from liver-only CRLM...
December 2020: Surgical Oncology
#2
MULTICENTER STUDY
Povilas Ignatavicius, Christian E Oberkofler, William C Chapman, Ronald P DeMatteo, Bryan M Clary, Michael I D'Angelica, Kenneth K Tanabe, Johnny C Hong, Thomas A Aloia, Timothy M Pawlik, Roberto Hernandez-Alejandro, Shimul A Shah, Jean-Nicolas Vauthey, Guido Torzilli, Hauke Lang, Pål-Dag Line, Olivier Soubrane, Hugo Pinto-Marques, Ricardo Robles-Campos, Karim Boudjema, Peter Lodge, René Adam, Christian Toso, Alejandro Serrablo, Luca Aldrighetti, Michelle L DeOliveira, Philipp Dutkowski, Henrik Petrowsky, Michael Linecker, Cäcilia S Reiner, Julia Braun, Ruslan Alikhanov, Giedrius Barauskas, Albert C Y Chan, Jiahong Dong, Norihiro Kokudo, Masakazu Yamamoto, Koo Jeong Kang, Yuman Fong, Mohamed Rela, Xabier De Aretxabala, Eduardo De Santibañes, Miguel Ángel Mercado, Oscar C Andriani, Orlando Jorge M Torres, Antonio D Pinna, Pierre-Alain Clavien
OBJECTIVE: To test the degree of agreement in selecting therapeutic options for patients suffering from colorectal liver metastasis (CRLM) among surgical experts around the globe. SUMMARY/BACKGROUND: Only few areas in medicine have seen so many novel therapeutic options over the past decades as for liver tumors. Significant variations may therefore exist regarding the choices of treatment, even among experts, which may confuse both the medical community and patients...
November 2020: Annals of Surgery
#3
REVIEW
Safi Dokmak, Béatrice Aussilhou, Wael Rebai, François Cauchy, Jacques Belghiti, Olivier Soubrane
BACKGROUND: The liver hanging maneuver (LHM) was described by Belghiti et al. to facilitate liver resection and is done classically by creating a space between the caudate lobe and the inferior vena cava starting on the edge of caudate lobe and extending cranially, in a para-caval fashion, towards the space between the right and middle hepatic veins. LHM facilitates liver transection, guides anatomical resections, decreases blood loss, facilitates harvesting of the liver graft in live donors, and also has oncological advantages...
February 2021: Langenbeck's Archives of Surgery
#4
JOURNAL ARTICLE
Efstratia Baili, Diamantis I Tsilimigras, Dimitrios Moris, Kota Sahara, Timothy M Pawlik
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) represents a novel surgical technique which provides rapid and effective liver regeneration allowing for the resection of lesions initially deemed unresectable. The objective of this systematic review is to summarize all technical modifications of the original ALPPS approach (mALPPS) for primary liver malignancies and evaluate short- and long-term outcomes. A systematic search of the literature was conducted using PubMed, Scopus, Cochrane Library Central, Google Scholar, and clinicaltrials...
June 2020: Surgical Oncology
#5
RANDOMIZED CONTROLLED TRIAL
Wentao Tang, Li Ren, Tianshu Liu, Qinghai Ye, Ye Wei, Guodong He, Qi Lin, Xiaoying Wang, Mingliang Wang, Fei Liang, Yuehong Cui, Jianmin Xu
PURPOSE: To assess the effects of bevacizumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) as first-line treatment of RAS mutant unresectable colorectal liver metastases. METHODS: From October 2013 to December 2017, patients with RAS mutant unresectable liver-limited metastases from colorectal cancer were randomly assigned to receive mFOLFOX6 plus bevacizumab (arm A) or mFOLFOX6 alone (arm B). The resectability of liver metastases was determined by a local multidisciplinary team...
September 20, 2020: Journal of Clinical Oncology
#6
LETTER
Svein Dueland, Pål-Dag Line
No abstract text is available yet for this article.
December 1, 2021: Annals of Surgery
#7
JOURNAL ARTICLE
Kota Sahara, Diamantis I Tsilimigras, Amika Moro, Rittal Mehta, J Madison Hyer, Anghela Z Paredes, Joal D Beane, Itaru Endo, Timothy M Pawlik
BACKGROUND: Although previous studies have suggested that drain management is highly variable, data on drain placement and timing of drain removal among patients undergoing hepatic resection remain scarce. The objective of the current study was to define the utilization of drain placement among patients undergoing major hepatic resection. METHODS: The ACS NSQIP-targeted hepatectomy database was used to identify patients who underwent major hepatectomy between 2014 and 2017...
April 27, 2020: Journal of Gastrointestinal Surgery
#8
REVIEW
Juan Glinka, Victoria Ardiles, Juan Pekolj, Juan Mattera, Rodrigo Sanchez Clariá, Eduardo de Santibañes, Martin de Santibañes
PURPOSE: Almost 50% of patients diagnosed with colorectal cancer (CRC) will develop liver metastasis (LM). Although their only long-term curative treatment is surgery, less than half of these patients can be eventually resected. Therefore, palliative chemotherapy is offered as a definitive option, though with poor results. Recently, the University of Oslo group has published encouraging results in the treatment of these patients with liver transplantation (LT), whereby worldwide interest in this option has been renewed...
May 2020: Langenbeck's Archives of Surgery
#9
RANDOMIZED CONTROLLED TRIAL
Pablo E Serrano, Chu-Shu Gu, Carol-Anne Moulton, Mohamed Husien, Diederick Jalink, Guillaume Martel, Melanie E Tsang, Julie Hallet, Vivian McAlister, Steven Gallinger, Mark Levine
BACKGROUND: Preoperative evaluation of resectable colorectal cancer liver metastases with positron emission tomography (PET) combined with computed tomography (PET-CT) is used extensively. The PETCAM trial evaluated the effect of PET-CT (intervention) vs no PET-CT (control) on surgical management. PET-CT resulted in 8% change in surgical management, therefore, we aimed to compare long-term outcomes (disease-free [DFS], overall survival [OS]). METHODS: Trial recruitment (2005-2010) had prospective follow-up until 2013...
May 2020: Journal of Surgical Oncology
#10
MULTICENTER STUDY
Jason T Wiseman, Francisco Guzman-Pruneda, Dimitrios Xourafas, Yun Shin Chun, Aslam Ejaz, Allan Tsung, Timothy M Pawlik, Jordan M Cloyd
BACKGROUND: The role of neoadjuvant chemotherapy in the management of colorectal liver metastases remains controversial. We sought to investigate whether neoadjuvant systemic chemotherapy contributes to clinically significant increases in postoperative morbidity and mortality using a population-based cohort. STUDY DESIGN: The American College of Surgeons NSQIP Targeted Hepatectomy Participant Use Files were queried from 2014 to 2016 to identify patients with colorectal liver metastases who underwent liver resection...
July 2019: Journal of the American College of Surgeons
#11
REVIEW
C J Isfordink, M Samim, M N G J A Braat, A M Almalki, J Hagendoorn, I H M Borel Rinkes, I Q Molenaar
An important risk of major hepatic resection is postoperative liver failure, which is directly related to insufficient future liver remnant (FLR). Portal vein embolization (PVE) and portal vein ligation (PVL) can minimize this risk by inducing hypertrophy of the FLR. The aim of this systematic review and meta-analysis was to compare the efficacy and safety of PVE and PVL for FLR hypertrophy. A systematic search was conducted on the17th of January 2017. The methodological quality of the studies was assessed using the Oxford Critical Appraisal Skills Program for cohort studies...
September 2017: Surgical Oncology
#12
JOURNAL ARTICLE
Claudius Conrad, Jean-Nicolas Vauthey, Okuno Masayuki, Rahul A Sheth, Suguru Yamashita, Guillaume Passot, Christina E Bailey, Daria Zorzi, Scott Kopetz, Thomas A Aloia, Y Nancy You
BACKGROUND: The optimal treatment sequence for patients with advanced rectal cancer and synchronous resectable liver metastases is controversial. We examined the outcomes associated with an individualized selection of classic, reversed, or combined approaches. METHODS: Between 1999 and 2014, 268 patients with rectal cancer and synchronous liver-only metastases underwent curative-intent multimodality therapy. Demographics and tumor and treatment details were reviewed...
December 2017: Annals of Surgical Oncology
#13
JOURNAL ARTICLE
Katsunori Imai, Carlos Castro Benitez, Marc-Antoine Allard, Eric Vibert, Antonio Sa Cunha, Daniel Cherqui, Denis Castaing, Henri Bismuth, Hideo Baba, René Adam
OBJECTIVE: To evaluate the impact of repeat surgery for recurrence on the long-term survival after 2-stage hepatectomy (TSH) for extensive colorectal liver metastases (CRLM). BACKGROUND: Although TSH is now deemed effective for selected patients with extensive bilobar CRLM, disease recurrence after TSH is very frequent because of the extensive tumor load. METHODS: Among a total cohort of 1235 patients who underwent hepatectomy for CRLM between 1992 and 2012, 139 with extensive bilobar CRLM were scheduled for TSH...
February 2019: Annals of Surgery
#14
JOURNAL ARTICLE
Jonathan S Abelson, Fabrizio Michelassi, Tianyi Sun, Jialin Mao, Jeffrey Milsom, Benjamin Samstein, Art Sedrakyan, Heather L Yeo
BACKGROUND: Optimal surgical management for patients with synchronous colorectal cancer liver metastasis is controversial. We provide an analysis of surgical utilization and outcomes for patients presenting with synchronous colon and rectal cancer liver metastasis between simultaneous and staged approaches. METHODS: SPARCS database was used to follow patients undergoing surgery for colorectal cancer with liver metastases from 2005 to 2014. Using International Classification of Diseases, Ninth Revision codes, we identified patients undergoing staged and simultaneous resection...
June 2017: Journal of Gastrointestinal Surgery
#15
JOURNAL ARTICLE
Leonid Barkhatov, Åsmund A Fretland, Airazat M Kazaryan, Bård I Røsok, Kristoffer W Brudvik, Anne Waage, Bjørn A Bjørnbeth, Mushegh A Sahakyan, Bjørn Edwin
OBJECTIVE: The aim of this study was to validate clinical risk scores in patients underwent laparoscopic resection of colorectal liver metastases (CLM) with 5 years follow-up or more, and assess 5- and 10-year actual survival in this group. METHODS: A total of 516 laparoscopic liver resections were performed in 406 patients with CLM between February 1998 and September 2015. A follow-up of 5 and 10 years could be assessed in 144 and 29 patients, respectively. The Fong score, pre- and postoperative Basingstoke Predictive Index (BPI), Nordlinger score, and Iwatsuki score were validated...
November 2016: Journal of Surgical Oncology
#16
REVIEW
Lee M Ocuin, Allan Tsung
Utilization of robotic techniques for resection of the liver is slowly gaining acceptance in specific situations and is now being applied to more challenging endeavors, such as major hepatectomy for cancer. This review provides a summary of robotic applications in liver surgery, with specific attention perioperative outcomes, oncologic outcomes, cost, and comparison to conventional laparoscopic techniques of liver resection. We also discuss future applications of robotic-assisted liver surgery.
September 2015: Journal of Surgical Oncology
#17
COMPARATIVE STUDY
Neda Amini, Yuhree Kim, Omar Hyder, Gaya Spolverato, Christopher L Wu, Andrew J Page, Timothy M Pawlik
BACKGROUND: We sought to define trends in the use of epidural analgesia (EA) for hepatopancreatic procedures, as well as to characterize inpatient outcomes relative to the use of EA. METHODS: The Nationwide Inpatient Sample database was queried to identify all elective hepatopancreatic surgeries between 2000 and 2012. In-hospital outcomes were compared among patients receiving EA vs conventional analgesia using propensity matching. RESULTS: EA utilization was 7...
September 2015: American Journal of Surgery
#18
JOURNAL ARTICLE
Guido Torzilli, Fabio Procopio, Matteo Cimino, Matteo Donadon, Daniele Del Fabbro, Guido Costa, Carlos A Garcia-Etienne
BACKGROUND: Two-stage hepatectomies generally are selected for patients with multiple bilobar colorectal liver metastases (CLMs) involving the hepatic veins (HV) at the caval confluence to reduce the risk of postoperative hepatic failure due to insufficient remnant liver.1 (,) 2 The use of IOUS based on well-established criteria offers alternative technical solutions to the staged resections.3 (,) 4 This report describes a sophisticated IOUS-guided parenchyma-sparing procedure. METHODS: A 57-year-old woman with multiple CLMs underwent surgery...
May 2015: Annals of Surgical Oncology
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