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John M Strasswimmer
No abstract text is available yet for this article.
September 2015: JAMA Dermatology
M C Urgert, M T van den Elzen, A C Knulst, Z Fedorowicz, E J van Zuuren
Chronic spontaneous urticaria (CSU) is characterized by the occurrence of hives, angio-oedema or both for a period of at least 6 weeks. Many patients remain symptomatic despite treatment with H1 antihistamines, even at higher doses. This systematic review assessed the quality of the evidence for the effects of omalizumab as treatment in patients with CSU. We searched PubMed, the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials up to 7 August 2014. Three review authors independently carried out study selection, risk of bias assessment and data extraction...
August 2015: British Journal of Dermatology
Jennifer L DePry, Ritva Vyas, Hillard M Lazarus, Paolo F Caimi, Meg R Gerstenblith, Jeremy S Bordeaux
IMPORTANCE: Hematopoietic cell transplantation has increased the survival of patients with several types of malignant hematologic disease and hematologic disorders; however, these patients have an increased risk of posttransplant cutaneous malignant neoplasms. Physicians should be aware of associated risk factors to provide appropriate patient screening and long-term care. OBJECTIVE: To identify the incidence and risk factors for cutaneous malignant neoplasms following hematopoietic cell transplantation...
July 2015: JAMA Dermatology
Franziska Schulze, Kathrin Neumann, Andreas Recke, Detlef Zillikens, Roland Linder, Enno Schmidt
No abstract text is available yet for this article.
May 2015: Journal of Investigative Dermatology
Mikio Ohtsuka, Takako Miura, Tatsuhiko Mori, Masato Ishikawa, Toshiyuki Yamamoto
No abstract text is available yet for this article.
July 2015: JAMA Dermatology
Anne M Kuwabara, Barbara M Rainer, Hatice Basdag, Bernard A Cohen
BACKGROUND: The purpose is to investigate the demographics and course of common warts in children in an outpatient setting. METHODS: A retrospective medical chart review and telephone survey study were completed on an outpatient cohort of children (0-17 yrs) with a clinical diagnosis of warts at a single-center, university-based pediatric dermatology practice. The main outcome measures included management, time to resolution, and associated factors of warts in children...
September 2015: Pediatric Dermatology
Gonul Catli, Ilknur Bostanci, Serap Ozmen, Emine Dibek Misirlioglu, Handan Duman, Ulker Ertan
BACKGROUND: Atopy patch testing is a useful way to determine delayed-type hypersensitivity reactions to foods and aeroallergens. Although food additives have been accused of worsening atopic eczema symptoms, according to recent studies the role of food additives in atopic eczema remains unclear. The purpose of our study was to investigate food additive hypersensitivity in a group of children with atopic eczema by using standardized atopy patch testing and to determine the role of food additive hypersensitivity in atopic eczema...
September 2015: Pediatric Dermatology
Robert E Hunger, Sarina Angermeier, S Morteza Seyed Jafari, Adrian Ochsenbein, Maziar Shafighi
BACKGROUND: Most guidelines recommend at least 2-cm excision margin for melanomas thicker than 2 mm. OBJECTIVE: We evaluated whether 1- or 2-cm excision margins for melanoma (>2 mm) result in different outcomes. METHODS: This is a retrospective cohort study on patients with melanomas (>2 mm) who underwent tumor excision with 1-cm (228 patients) or 2-cm (97 patients) margins to investigate presence of local recurrences, locoregional and distant metastases, and disease-free and overall survival...
June 2015: Journal of the American Academy of Dermatology
Asuman Gürkan, Sare Gülfem Özlü, Pınar Altıaylık-Özer, Bengi Ece Kurtul, Can Demir Karacan, Saliha Şenel
BACKGROUND: Recurrent aphthous stomatitis (RAS) is a common oral ulcerative condition in children. The objective was to describe the clinical features of RAS in children with accompanying clinical and laboratory findings. METHODS: The study included 120 patients younger than 18 years of age (mean age 9.6 ± 4.3 years) with three or more oral aphthous ulcers per year between August 2008 and February 2014. Demographic characteristics of the patients, clinical features of the ulcers, and associated clinical and laboratory findings were evaluated...
July 2015: Pediatric Dermatology
Erqi L Pollom, Timothy T Bui, Anne Lynn S Chang, A Dimitrios Colevas, Wendy Y Hara
IMPORTANCE: Vismodegib is a targeted agent recently approved for treating patients who develop recurrent or locally advanced basal cell carcinoma (BCC), and will inevitably be integrated into existing therapy for advanced BCC as it becomes increasingly used. Improved understanding of how vismodegib interacts with other treatment modalities, including radiotherapy, would help optimize multidisciplinary therapy and clinical outcomes. OBSERVATIONS: We report 2 cases of recurrent, advanced BCC treated from April 1, 2012, through October 31, 2014, with concurrent radiotherapy and vismodegib...
September 2015: JAMA Dermatology
Brian J Simmons, Robert D Griffith, Leyre A Falto-Aizpurua, Keyvan Nouri
No abstract text is available yet for this article.
April 2015: JAMA Dermatology
Christopher R Kieliszak, Tess H Pollinger, Megha M Tollefson, John R Griffin
The umbilicus may be the site of congenital and acquired malformations and may harbor clinical clues to the diagnosis of potentially fatal inherited disorders, primary skin conditions, and a variety of infectious diseases. Both benign and malignant tumors may involve the umbilicus, and some are unique to this site. Finally, cutaneous signs localized to this anatomic location may be found in diverse systemic diseases.
June 2015: Journal of the American Academy of Dermatology
Laureline Legendre, Thomas Barnetche, Juliette Mazereeuw-Hautier, Nicolas Meyer, Dedee Murrell, Carle Paul
BACKGROUND: There is controversy regarding a potential increased risk of lymphoma in patients with atopic dermatitis (AD). OBJECTIVE: To assess the risk of lymphoma and the role of topical treatments in patients with AD. METHODS: A systematic literature search and a separate meta-analysis were performed on case control and cohort studies. RESULTS: Of the 3979 articles retrieved, 24 references met the inclusion criteria...
June 2015: Journal of the American Academy of Dermatology
Alina Goldenberg, Arisa Ortiz, Silvia S Kim, S Brian Jiang
BACKGROUND: Squamous cell carcinoma with aggressive subclinical extension (SCC-ASE) is a tumor whose extensive spread becomes revealed during surgery or pathologic review, particularly during Mohs micrographic surgery. Limited clinical awareness of these lesions may result in unanticipated longer surgical times and larger postoperative defects. SCC-ASE-associated clinical risk factors are not well studied. OBJECTIVE: We sought to evaluate the incidence of and risk factors associated with SCC-ASE...
July 2015: Journal of the American Academy of Dermatology
Aditi Choudhry, Judith Hong, Kim Chong, Betty Jiang, Rebecca Hartman, Emily Chu, Kelly Nelson, Maria L Wei, Tien Nguyen
IMPORTANCE: Effective patient-physician communication is essential for optimal health care. Recent introduction of online patient portals to access test results are changing the communication landscape, but regulatory guidelines for the online release of biopsy results vary from state to state. OBJECTIVES: To assess patient preferences for receiving skin biopsy results to rule out melanoma and to compare those preferences to current physicians' practices for notification...
May 2015: JAMA Dermatology
Reshmi Madankumar, Marie C Leger, Jennifer A Stein
No abstract text is available yet for this article.
May 2015: JAMA Dermatology
Thomas J Moore
No abstract text is available yet for this article.
June 2015: JAMA Dermatology
Elin S Gray, Anna L Reid, Samantha Bowyer, Leslie Calapre, Kelvin Siew, Robert Pearce, Lester Cowell, Markus H Frank, Michael Millward, Mel Ziman
Metastatic melanoma is a highly heterogeneous tumor; thus, methods to analyze tumor-derived cells circulating in blood should address this diversity. Taking this into account, we analyzed, using multiparametric flow cytometry, the co-expression of the melanoma markers melanoma cell adhesion molecule and melanoma-associated chondroitin sulphate proteoglycan and the tumor-initiating markers ATP-binding cassette sub-family B member 5 (ABCB5), CD271, and receptor activator of NF-κβ (RANK) in individual circulating tumor cells (CTCs) from 40 late-stage (III-IV) and 16 early-stage (I-II) melanoma patients...
August 2015: Journal of Investigative Dermatology
R N Matin
No abstract text is available yet for this article.
April 2015: British Journal of Dermatology
Natalia Jaimes, Ashfaq A Marghoob, Harold Rabinovitz, Ralph P Braun, Alan Cameron, Cliff Rosendahl, Greg Canning, Jeffrey Keir
BACKGROUND: Melanomas on chronically sun-damaged skin (CSDS) can be difficult to identify and often manifest morphologic features that overlap with benign lesions. OBJECTIVE: We describe and analyze the clinical and dermoscopic characteristics of melanomas on nonfacial CSDS. METHODS: Melanoma cases on nonfacial CSDS were retrospectively identified from the biopsy specimen logs of 6 melanoma clinics. Clinical and dermoscopic images were combined into 1 database...
June 2015: Journal of the American Academy of Dermatology
2015-04-19 22:38:03
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