Kiel D Neumann, Donna K Broshek, Benjamin T Newman, T Jason Druzgal, Bijoy K Kundu, Jacob E Resch
Sport concussion affects millions of athletes each year at all levels of sport. Increasing evidence demonstrates clinical and physiological recovery are becoming more divergent definitions, as evidenced by several studies examining blood-based biomarkers of inflammation and imaging studies of the central nervous system (CNS). Recent studies have shown elevated microglial activation in the CNS in active and retired American football players, as well as in active collegiate athletes who were diagnosed with a concussion and returned to sport...
August 22, 2023: Cells
Marina Zeldovich, Fabian Bockhop, Amra Covic, Isabelle Mueller, Suzanne Polinder, Ana Mikolic, Marjolein van der Vlegel, Nicole von Steinbuechel
BACKGROUND: Comparison of patient-reported outcomes in multilingual studies requires evidence of the equivalence of translated versions of the questionnaires. The present study examines the factorial validity and comparability of six language versions of the Rivermead Post-Concussion Symptoms Questionnaire (RPQ) administered to individuals following traumatic brain injury (TBI) in the Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) study. METHODS: Six competing RPQ models were estimated using data from Dutch (n = 597), English (n = 223), Finnish (n = 213), Italian (n = 268), Norwegian (n = 263), and Spanish (n = 254) language samples recruited six months after injury...
September 8, 2023: Journal of Patient-Reported Outcomes
Ingerid Kleffelgård, Nada Andelic, Kari Anette Bruusgaard, Birgitta Langhammer, Anne-Lise Tamber, Helene Lundgaard Soberg
Persisting dizziness and balance problems after mild-to-moderate traumatic brain injury (mmTBI) may result in considerable disability. The primary aim of this study was to explore the factors associated with dizziness-related disability one year post-injury. Data from 64 participants (mean age 39.4 [SD 13.0] years; 45 [70.3%] women) with mmTBI from a previous randomised controlled trial were analysed using simple and multiple regression analyses (Clinical Trials Registry #NCT01695577). The Dizziness Handicap Inventory one year (12...
August 9, 2023: Journal of Clinical Medicine
Gian-Gabriel P Garcia, Lauren L Czerniak, Mariel S Lavieri, Spencer W Liebel, Kathryn L Van Pelt, Paul F Pasquina, Thomas W McAllister, Michael A McCrea, Steven P Broglio
BACKGROUND: A key component of return-to-play (RTP) from sport-related concussion is the symptom-free waiting period (SFWP), i.e., the period during which athletes must remain symptom-free before permitting RTP. Yet, the exact relationship between SFWP and post-RTP injury rates is unclear. OBJECTIVE: We design computational simulations to estimate the relationship between the SFWP and rates of repeat concussion and non-concussion time-loss injury up to 30 days post-RTP for male and female collegiate athletes across 13 sports...
August 23, 2023: Sports Medicine
Ethan Danielli, Nicholas Simard, Carol A DeMatteo, Dinesh Kumbhare, Stephan Ulmer, Michael D Noseworthy
The human brain is an exceptionally complex organ that is comprised of billions of neurons. Therefore, when a traumatic event such as a concussion occurs, somatic, cognitive, behavioral, and sleep impairments are the common outcome. Each concussion is unique in the sense that the magnitude of biomechanical forces and the direction, rotation, and source of those forces are different for each concussive event. This helps to explain the unpredictable nature of post-concussion symptoms that can arise and resolve...
2023: Frontiers in Neurology
Serge Belhassen, Quentin Mat, Claude Ferret, Robert Clavel, Bernard Renaud, Pierre Cabaraux
Mild traumatic brain injury (mTBI) and whiplash injury (WI) may lead to long-term disabling consequences known as post-concussive syndrome (PCS) and whiplash-associated disorders (WADs). PCS and WAD patients commonly complain of conditions encompassing dizziness, vertigo, headache, neck pain, visual complaints, anxiety, and neurocognitive dysfunctions. A proper medical work-up is a priority in order to rule out any acute treatable consequences. However investigations may remain poorly conclusive. Gathered in the head and neck structures, the ocular sensorimotor, the vestibular, and the cervical proprioceptive systems, all involved in postural control, may be damaged by mTBI or WI...
July 2023: Brain & NeuroRehabilitation
Håkan Ashina, David W Dodick, Jason Barber, Nancy R Temkin, Catherine D Chong, Jennifer S Adler, Ken Shubin Stein, Todd J Schwedt, Geoffrey T Manley
OBJECTIVE: To ascertain the prevalence of and risk factors for post-traumatic headache (PTH) attributed to mild traumatic brain injury (mTBI). PATIENTS AND METHODS: A prospective, longitudinal, multicenter cohort study of patients with mTBI and orthopedic trauma controls who were enrolled from February 26, 2014, to August 8, 2018. The baseline assessment was conducted as soon as possible following evaluation at the emergency department. Follow-ups were scheduled at 2 weeks, 3 months, 6 months, and 12 months postinjury...
July 21, 2023: Mayo Clinic Proceedings
Abdulaziz A Alkathiry
OBJECTIVES: To assesse the characteristics and validity of the Functional Gait Assessment (FGA). Concussion is a frequent brain injury that affect cognition, balance, and mobility. Prediction of the course of recovery after concussion could be achieved using a multidimensional examination. The FGA has been used to assess balance of individuals with concussion. METHODS: A prospective cross-sectional study was commenced between 2015-2020 in Pittsburgh, PA, USA, including 27 high schoolers with current complaints of concussion and 86 healthy controls...
July 2023: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
Rishi S Madnani
Alzheimer's disease (AD), the most common form of dementia, is a striking example of the connection between neurophysiological abnormalities and higher-order cognitive deficiencies. Since its initial description in 1906, research into the pathophysiology and etiology of AD has led to the illumination of an incredibly complex set of genetic and molecular mechanisms for the disease's progression, characterized by much more than the neuropathological hallmarks of beta-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs)...
2023: Frontiers in Neurology
Julien Déry, Béatrice Ouellet, Élaine de Guise, Ève-Line Bussières, Marie-Eve Lamontagne
BACKGROUND: Mild traumatic brain injury (mTBI) is an increasing public health problem, because of its persistent symptoms and several functional consequences. Understanding the prognosis of a condition is an important component of clinical decision-making and can help to guide the prevention of persistent symptoms following mTBI. The prognosis of mTBI has stimulated several empirical primary research papers and many systematic reviews leading to the identification of a wide range of factors...
July 20, 2023: Systematic Reviews
Ashley L Ware, Matthew J W McLarnon, Andrew P Lapointe, Brian L Brooks, Ann Bacevice, Barbara A Bangert, Miriam H Beauchamp, Erin D Bigler, Bruce Bjornson, Daniel M Cohen, William Craig, Quynh Doan, Stephen B Freedman, Bradley G Goodyear, Jocelyn Gravel, H Leslie K Mihalov, Nori Mercuri Minich, H Gerry Taylor, Roger Zemek, Keith Owen Yeates
OBJECTIVES: This study investigated IQ scores in pediatric concussion (ie, mild traumatic brain injury) versus orthopedic injury. METHODS: Children (N = 866; aged 8-16.99 years) were recruited for 2 prospective cohort studies from emergency departments at children's hospitals (2 sites in the United States and 5 in Canada) ≤48 hours after sustaining a concussion or orthopedic injury. They completed IQ and performance validity testing postacutely (3-18 days postinjury; United States) or 3 months postinjury (Canada)...
July 17, 2023: Pediatrics
Ioannis Mavroudis, Alin Ciobica, Alina Costina Luca, Ioana-Miruna Balmus
Post-traumatic headache (PTH) is a common and debilitating consequence of mild traumatic brain injury (mTBI) that can occur over one year after the head impact event. Thus, better understanding of the underlying pathophysiology and risk factors could facilitate early identification and management of PTH. There are several factors that could influence the reporting of PTH prevalence, including the definition of concussion and PTH. The main risk factors for PTHs include a history of migraines or headaches, female gender, younger age, greater severity of the head injury, and co-occurring psychological symptoms, such as anxiety and depression...
June 23, 2023: Journal of Clinical Medicine
Gabrielle Babula, Edward Warunek, Katherine Cure, Grace Nikolski, Heather Fritz, Susan Barker
BACKGROUND: Sports-related concussions (SRC) are a common injury sustained by many athletes of all different age groups and sports. The current standard treatment is rest followed by aerobic activity. Minimal research has been done on the effects of vestibular rehabilitation for concussion treatment, especially in physical therapy practice. OBJECTIVE: The purpose of this study was to examine the effects of early intervention of vestibular rehabilitation (VRT) on an athlete's time to return to play compared to rest alone...
2023: International Journal of Sports Physical Therapy
Erik Hohmann, Paul Bloomfield, Jiri Dvorak, Ruben Echemendia, Rachel M Frank, Janesh Ganda, Leigh Gordon, Louis Holtzhausen, Alan Kourie, Jerome Mampane, Michael Makdissi, Jon Patricios, Elizabeth Pieroth, Margot Putukian, Dina C Janse van Rensburg, Pierre Viviers, Vernon Williams, Jean de Wilde
PURPOSE: The purpose of this study was to perform a Delphi consensus for on-field and pitch-side assessment of sports related concussion (SRC). METHODS: Open-ended questions in rounds 1 and 2 were answered. The results of the first two rounds were used to develop a Likert style questionnaire for round 3. If agreement at round 3 was <80% for an item, if panel members were outside consensus or there were >30% neither agree/disagree responses, the results were carried forward into round 4...
June 28, 2023: Arthroscopy
Tara Caberwal, Amy S Cecchini, Laurel M Wentz, Cristóbal S Berry-Cabán
INTRODUCTION: Many of the injury mechanisms that cause mild traumatic brain injury (mTBI) also create forces commonly associated with whiplash, resulting in cervical pain injury. The prevalence of associated neck pain with mTBI is not well established. There is a strong indication that injury to the cervical spine may aggravate, cause, and/or impact recovery of symptoms and impairments associated with the concussive event and its primary effect on the brain. The purpose of this study is to help identify the prevalence of ensuing cervical pain within 90 days of a previously documented mTBI and to examine the role of neck pain during concurrent concussive symptoms, in a military population stationed at a large military installation...
June 29, 2023: Military Medicine
E Anarte-Lazo, D Abichandani, C Rodriguez-Blanco, C Bernal-Utrera, D Falla
BACKGROUND: Whiplash-associated headache (WAH) is one of the most common symptoms after a whiplash injury, leading to high disability. Nevertheless, the clinical characteristics of WAH have not been well described. OBJECTIVE: To synthesise the existing literature on the clinical characteristics of WAH. DESIGN: Scoping review. METHODS: The protocol for this scoping review was registered in Open Science Framework and the PRISMA extension for Scoping Reviews tool was used to ensure methodological and reporting quality...
June 18, 2023: Musculoskeletal Science & Practice
Shawn R Eagle, Ava M Puccio, Denes V Agoston, Ryan Soose, Michael Mancinelli, Rachel Nwafo, Peyton McIntyre, Allison Agnone, Savannah Tollefson, Michael Collins, Anthony P Kontos, Walter Schneider, David O Okonkwo
Chronic consequences of mild traumatic brain injury (mTBI) are heterogeneous, but may be treatable with targeted medical and rehabilitation interventions. A biological signature for the likelihood of response to therapy (i.e., "predictive" biomarkers) would empower personalized medicine post-mTBI. The purpose of this study was to correlate pre-intervention blood biomarker levels and the likelihood of response to targeted interventions for patients with chronic issues attributable to mTBI. Patients with chronic symptoms and/or disorders secondary to mTBI >3 months previous (104 days to 15 years; n  = 74) were enrolled...
2023: Neurotrauma reports
Andrew Crane, Analise Roccaforte, Frank Webbe, Anthony LoGalbo
OBJECTIVE: Concussion is a growing public health concern given the large number of youth and collegiate athletes participating in collision sports. Sport-related concussions can have an adverse impact on student-athletes' health and academic performance. Athletic programs within academic organizations are motivated to employ the most effective and efficient diagnostic and recovery procedures to minimize the duration and impact of these symptoms on student-athletes' functioning. The present study sought to further our understanding regarding the value and frequency of conducting baseline assessments when evaluating sport-related concussions...
June 22, 2023: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
Ammar Aljabri, Alhussain Halawani, Alaa Ashqar, Omar Alageely, Adel Alhazzani
OBJECTIVE: Mild traumatic brain injury (mTBI) or concussion is a common yet undermanaged and underreported condition. This systematic review and meta-analysis aim to determine the efficacy of vestibular rehabilitation therapy (VRT) as a treatment option for mTBI. METHOD: This review and meta-analysis was performed following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. It included randomized controlled trials and pre-VRT/post-VRT retrospective chart reviews...
June 19, 2023: Journal of Head Trauma Rehabilitation
Andreas Sakkas, Christel Weiß, Frank Wilde, Marcel Ebeling, Mario Scheurer, Oliver Christian Thiele, Robert Andreas Mischkowski, Sebastian Pietzka
The primary aim was to evaluate the compliance of cranial CT indication with the national guideline-based decision rules in patients after mTBI. The secondary aim was to determine the incidence of CT pathologies among justified and unjustified CT scans and to investigate the diagnostic value of these decision rules. This is a retrospective, single-center study on 1837 patients (mean age = 70.7 years) referred to a clinic of oral and maxillofacial surgery following mTBI over a five-year period. The current national clinical decision rules and recommendations for mTBI were retrospectively applied to calculate the incidence of unjustified CT imaging...
May 23, 2023: Diagnostics
2023-06-17 12:32:48
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