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Pancreatic cancer

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167 papers 25 to 100 followers Pancreatic cancer
https://read.qxmd.com/read/30570546/precision-oncology-in-surgery-patient-selection-for-operable-pancreatic-cancer
#1
Stephan B Dreyer, Mark Pinese, Nigel B Jamieson, Christopher J Scarlett, Emily K Colvin, Marina Pajic, Amber L Johns, Jeremy L Humphris, Jianmin Wu, Mark J Cowley, Angela Chou, Adnan M Nagrial, Lorraine Chantrill, Venessa T Chin, Marc D Jones, Kim Moran-Jones, Christopher Ross Carter, Euan J Dickson, Jaswinder S Samra, Neil D Merrett, Anthony J Gill, James G Kench, Fraser Duthie, David K Miller, Susanna Cooke, Daniela Aust, Thomas Knösel, Petra Rümmele, Robert Grützmann, Christian Pilarsky, Nam Q Nguyen, Elizabeth A Musgrove, Peter J Bailey, Colin J McKay, Andrew V Biankin, David K Chang
OBJECTIVE: We aimed to define preoperative clinical and molecular characteristics that would allow better patient selection for operative resection. BACKGROUND: Although we use molecular selection methods for systemic targeted therapies, these principles are not applied to surgical oncology. Improving patient selection is of vital importance for the operative treatment of pancreatic cancer (pancreatic ductal adenocarcinoma). Although surgery is the only chance of long-term survival, 80% still succumb to the disease and approximately 30% die within 1 year, often sooner than those that have unresected local disease...
November 30, 2018: Annals of Surgery
https://read.qxmd.com/read/30522947/contemporary-analysis-of-complications-associated-with-biliary-stents-during-neoadjuvant-therapy-for-pancreatic-adenocarcinoma
#2
Bradford J Kim, Laura Prakash, Nisha Narula, Catherine H Davis, Michael P Kim, Thomas A Aloia, Jean-Nicolas Vauthey, Jeffrey E Lee, Matthew H Katz, Ching-Wei D Tzeng
BACKGROUND: With the increasing use of biliary stents for neoadjuvant therapy (NT) for pancreatic adenocarcinoma (PDAC), the risk of post-pancreaticoduodenectomy (PD) infection remains relevant. This study documents the contemporary incidence of stent-related complications (SRC) during NT and to analyze their impact on surgical infections. METHODS: Consecutive patients from a single institution (2011-15) with resected PDAC treated with biliary decompression, NT, and PD were analyzed...
December 3, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30404163/a-comparative-quantitative-lc-ms-ms-profiling-analysis-of-human-pancreatic-adenocarcinoma-adjacent-normal-tissue-and-patient-derived-tumour-xenografts
#3
Orla Coleman, Michael Henry, Fiona O'Neill, Sandra Roche, Niall Swan, Lorraine Boyle, Jean Murphy, Justine Meiller, Neil T Conlon, Justin Geoghegan, Kevin C Conlon, Vincent Lynch, Ninfa L Straubinger, Robert M Straubinger, Gerard McVey, Michael Moriarty, Paula Meleady, Martin Clynes
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide; it develops in a relatively symptom-free manner, leading to rapid disease progression and metastasis, leading to a 5-year survival rate of less than 5%. A lack of dependable diagnostic markers and rapid development of resistance to conventional therapies are among the problems associated with management of the disease. A better understanding of pancreatic tumour biology and discovery of new potential therapeutic targets are important goals in pancreatic cancer research...
November 6, 2018: Proteomes
https://read.qxmd.com/read/30407289/learning-curves-for-robotic-pancreatic-surgery-from-distal-pancreatectomy-to-pancreaticoduodenectomy
#4
Bor-Uei Shyr, Shih-Chin Chen, Yi-Ming Shyr, Shin-E Wang
This study sought to identify the learning curves of console time (CT) for robotic pancreaticoduodenectomy (RPD) and robotic distal pancreatectomy (RDP). Perioperative outcomes were compared between the early group of surgeries performed early in the learning curve and the late group of surgeries performed after the learning curve.Pancreaticoduodenectomy (PD) is a technically demanding and challenging procedure carrying a high morbidity.Data for RDP and RPD were prospectively collected for analysis. The learning curve was assessed by cumulative sum (CUSUM)...
November 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30394883/plasma-mir-181a-5p-downregulation-predicts-response-and-improved-survival-after-folfirinox-in-pancreatic-ductal-adenocarcinoma
#5
Laura L Meijer, Ingrid Garajová, Chiara Caparello, Tessa Y S Le Large, Adam E Frampton, Enrico Vasile, Niccola Funel, Geert Kazemier, Elisa Giovannetti
OBJECTIVE: The aim of the study was to identify plasma microRNA (miRNA) biomarkers for stratifying and monitoring patients with locally advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) treated with FOLFIRINOX, and to investigate their functional roles. SUMMARY BACKGROUND DATA: FOLFIRINOX has become a standard therapy for patients with advanced PDAC and can be used to potentially downstage disease. However, only a subset of patients respond, and biomarkers to guide decision-making are urgently needed...
December 9, 2018: Annals of Surgery
https://read.qxmd.com/read/30292643/diagnosis-and-management-of-pancreatic-cancer-in-adults-a-summary-of-guidelines-from-the-uk-national-institute-for-health-and-care-excellence
#6
REVIEW
Derek O'Reilly, Linyun Fou, Elise Hasler, James Hawkins, Susan O'Connell, Ferruccio Pelone, Mark Callaway, Fiona Campbell, Margred Capel, Richard Charnley, Pippa Corrie, Dawn Elliot, Lesley Goodburn, Anna Jewell, Suzanne Joharchi, Laura McGeeney, Somnath Mukherjee, Kofi Oppong, Phil Whelan, John Primrose, John Neoptolemos
To enable standardisation of care of pancreatic cancer patients and facilitate improvement in outcome, the United Kingdom's National Institute for Health and Care Excellence (NICE) developed a clinical guideline for the diagnosis and management of pancreatic cancer in adults. Systematic literature searches, systematic review and meta-analyses were undertaken. Recommendations were drafted on the basis of the group's interpretation of the best available evidence of clinical and cost effectiveness. There was patient involvement and public consultation...
December 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/30298284/a-comparison-between-plastic-and-metallic-biliary-stent-placement-in-patients-receiving-preoperative-neoadjuvant-chemoradiotherapy-for-resectable-pancreatic-cancer
#7
Kota Nakamura, Masayuki Sho, Takahiro Akahori, Minako Nagai, Satoshi Nishiwada, Kenji Nakagawa, Toshihiro Tanaka, Kimihiko Kichikawa, Tetsuro Tamamoto, Masatoshi Hasegawa, Akira Mitoro, Hitoshi Yoshiji, Naoya Ikeda
BACKGROUND: The optimal stent type in patients receiving preoperative neoadjuvant chemoradiotherapy (NACRT) is uncertain. The present study aimed to compare the clinical effectiveness of biliary metallic stent (MS) and plastic stent (PS) in patients undergoing preoperative NACRT for resectable pancreatic cancer. METHODS: This retrospective study included 43 patients who required either biliary MS or PS before initiating NACRT for resectable or borderline resectable pancreatic head cancer...
February 2019: World Journal of Surgery
https://read.qxmd.com/read/30377050/density-and-enhancement-of-the-pancreatic-tail-on-computer-tomography-predicts-acinar-score-and-pancreatic-fistula-after-pancreatoduodenectomy
#8
Christopher B Nahm, Isaac Lui, Catherine S Naidoo, Lucian Roseverne, Saeed Alzaabi, Richard Maher, Georgina Mann, Steven Blome, Anthony J Gill, Jaswinder S Samra, Anubhav Mittal
BACKGROUND: Acinar score calculated at the pancreatic resection margin is associated with postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD). The present study evaluates the association between (i) computed tomography (CT) density of the pancreas and the acinar score of the pancreatic resection margin, and (ii) CT density of the pancreas and POPF after PD. METHODS: Consecutive patients who underwent PD were included for analysis. CT densities of the pancreatic head, neck, body and tail were measured in non-contrast (NC), arterial (ART) and portal venous (PV) phases...
October 27, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/30312198/importance-of-normalization-of-ca19-9-levels-following-neoadjuvant-therapy-in-patients-with-localized-pancreatic-cancer
#9
Susan Tsai, Ben George, David Wittmann, Paul S Ritch, Ashley N Krepline, Mohammed Aldakkak, Chad A Barnes, Kathleen K Christians, Kulwinder Dua, Michael Griffin, Catherine Hagen, William A Hall, Beth A Erickson, Douglas B Evans
OBJECTIVE: Carbohydrate antigen 19-9 (CA19-9) is a prognostic marker for patients with pancreatic cancer (PC), but its value as a treatment biomarker is unclear. SUMMARY BACKGROUND DATA: Although CA19-9 is an established prognostic marker for patients with PC, it is unclear how CA19-9 monitoring should be used to guide multimodality treatment and what level of change in CA19-9 constitutes a meaningful treatment response. METHODS: CA19-9 measurements at diagnosis (pretx), after completion of all planned neoadjuvant therapy (preop), and after surgery (postop) were analyzed in patients with localized PC who had an elevated CA19-9 (≥35 U/dL) at diagnosis...
October 11, 2018: Annals of Surgery
https://read.qxmd.com/read/29493784/propensity-score-matched-comparison-of-oncological-outcomes-between-laparoscopic-and-open-distal-pancreatic-resection
#10
MULTICENTER STUDY
M Raoof, P H G Ituarte, Y Woo, S G Warner, G Singh, Y Fong, L Melstrom
BACKGROUND: Selected studies have reported improved outcomes in laparoscopic compared with open distal pancreatic resection. Concerns regarding failure to achieve proper oncological resection and compromised long-term outcomes remain. This study investigated whether postoperative outcomes and long-term survival after laparoscopic distal pancreatectomy are comparable to those after an open procedure. METHODS: This retrospective case-control study included patients who underwent distal pancreatectomy for resectable pancreatic adenocarcinoma between 2010 and 2013, identified from the National Cancer Database...
April 2018: British Journal of Surgery
https://read.qxmd.com/read/29363018/surgical-anatomy-of-the-superior-mesenteric-vessels-related-to-pancreaticoduodenectomy-a-systematic-review-and-meta-analysis
#11
Ionut Negoi, Mircea Beuran, Sorin Hostiuc, Ruxandra Irina Negoi, Yosuke Inoue
BACKGROUND AND PURPOSE: Mesopancreas dissection with central vascular ligation and the superior mesenteric artery (SMA)-first approach represent the cornerstone of current principles for radical resection for pancreatic head cancer. The surgeon dissecting around the SMV and SMA should be aware regarding the anatomical variants in this area. The aims of this systematic review and meta-analysis are to detail the surgical anatomy of the superior mesenteric vessels and to propose a standardized terminology with impact in pancreatic cancer surgery...
May 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://read.qxmd.com/read/29334562/is-a-pathological-complete-response-following-neoadjuvant-chemoradiation-associated-with-prolonged-survival-in-patients-with-pancreatic-cancer
#12
Jin He, Alex B Blair, Vincent P Groot, Ammar A Javed, Richard A Burkhart, Georgios Gemenetzis, Ralph H Hruban, Kevin M Waters, Justin Poling, Lei Zheng, Daniel Laheru, Joseph M Herman, Martin A Makary, Matthew J Weiss, John L Cameron, Christopher L Wolfgang
OBJECTIVES: To describe the survival outcome of patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma (BR/LA-PDAC) who have a pathologic complete response (pCR) following neoadjuvant chemoradiation. BACKGROUND: Patients with BR/LA-PDAC are often treated with neoadjuvant chemoradiation in an attempt to downstage the tumor. Uncommonly, a pCR may result. METHODS: A retrospective review of a prospectively maintained database was performed at a single institution...
July 2018: Annals of Surgery
https://read.qxmd.com/read/29249649/systematic-review-on-the-impact-of-pancreatoduodenectomy-on-quality-of-life-in-patients-with-pancreatic-cancer
#13
REVIEW
Sven M van Dijk, Hanne D Heerkens, Dorine S J Tseng, Martijn Intven, I Quintus Molenaar, Hjalmar C van Santvoort
BACKGROUND: Patients undergoing pancreatoduodenectomy for pancreatic cancer have a high risk of major postoperative complications and a low survival rate. Insight in the impact of pancreatoduodenectomy on quality of life (QoL) is therefore of great importance. The aim of this systematic review was to assess QoL after pancreatoduodenectomy for pancreatic cancer. METHODS: A systematic review of the literature was performed according to the PRISMA guidelines. A systematic search of all the English literature available in PubMed and Medline was performed...
March 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/29307511/acinar-cell-density-at-the-pancreatic-resection-margin-is-associated-with-post-pancreatectomy-pancreatitis-and-the-development-of-postoperative-pancreatic-fistula
#14
Christopher B Nahm, Kai M Brown, Philip J Townend, Emily Colvin, Viive M Howell, Anthony J Gill, Saxon Connor, Jaswinder S Samra, Anubhav Mittal
BACKGROUND: There has been recent evidence supporting post-pancreatectomy pancreatitis as a factor in the development of postoperative pancreatic fistula (POPF). The aims of this study were to evaluate: (i) the correlation of the acinar cell density at the pancreatic resection margin with the intra-operative amylase concentration (IOAC) of peri-pancreatic fluid, postoperative pancreatitis, and POPF; and (ii) the association between postoperative pancreatitis on the first postoperative day and POPF...
May 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://read.qxmd.com/read/29240007/alternative-fistula-risk-score-for-pancreatoduodenectomy-a-frs-design-and-international-external-validation
#15
Timothy H Mungroop, L Bengt van Rijssen, David van Klaveren, F Jasmijn Smits, Victor van Woerden, Ralph J Linnemann, Matteo de Pastena, Sjors Klompmaker, Giovanni Marchegiani, Brett L Ecker, Susan van Dieren, Bert Bonsing, Olivier R Busch, Ronald M van Dam, Joris Erdmann, Casper H van Eijck, Michael F Gerhards, Harry van Goor, Erwin van der Harst, Ignace H de Hingh, Koert P de Jong, Geert Kazemier, Misha Luyer, Awad Shamali, Salvatore Barbaro, Thomas Armstrong, Arjun Takhar, Zaed Hamady, Joost Klaase, Daan J Lips, I Quintus Molenaar, Vincent B Nieuwenhuijs, Coen Rupert, Hjalmar C van Santvoort, Joris J Scheepers, George P van der Schelling, Claudio Bassi, Charles M Vollmer, Ewout W Steyerberg, Mohammed Abu Hilal, Bas Groot Koerkamp, Marc G Besselink
OBJECTIVE: The aim of this study was to develop an alternative fistula risk score (a-FRS) for postoperative pancreatic fistula (POPF) after pancreatoduodenectomy, without blood loss as a predictor. BACKGROUND: Blood loss, one of the predictors of the original-FRS, was not a significant factor during 2 recent external validations. METHODS: The a-FRS was developed in 2 databases: the Dutch Pancreatic Cancer Audit (18 centers) and the University Hospital Southampton NHS...
December 12, 2017: Annals of Surgery
https://read.qxmd.com/read/29265404/randomized-clinical-trial-of-duct-to-mucosa-versus-invagination-pancreaticojejunostomy-after-pancreatoduodenectomy
#16
RANDOMIZED CONTROLLED TRIAL
Y Senda, Y Shimizu, S Natsume, S Ito, K Komori, T Abe, K Matsuo, T Sano
BACKGROUND: The postoperative pancreatic fistula (POPF) rate for duct-to-mucosa and invagination anastomosis after pancreatoduodenectomy is still debated. The aim of this RCT was to investigate the POPF rate for duct-to-mucosa versus invagination pancreaticojejunostomy. METHODS: Patients were stratified by pancreatic texture and diameter of the main pancreatic duct and randomized to the duct-to-mucosa or invagination group. The primary endpoint was the rate of clinically relevant POPF (defined as grade B or C)...
January 2018: British Journal of Surgery
https://read.qxmd.com/read/29119533/18-fluorodeoxyglucose-positron-emission-tomography-predicts-recurrence-in-resected-pancreatic-ductal-adenocarcinoma
#17
Kyohei Ariake, Fuyuhiko Motoi, Hideo Shimomura, Masamichi Mizuma, Shimpei Maeda, Chiaki Terao, Yasuko Tatewaki, Hideo Ohtsuka, Koji Fukase, Kunihiro Masuda, Hiroki Hayashi, Tatsuyuki Takadate, Takeshi Naitoh, Yasuyuki Taki, Michiaki Unno
BACKGROUND: We aimed to determine whether treatment should be stratified according to 18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) maximum standardized uptake values (SUVmax ) in pancreatic ductal adenocarcinoma. METHODS: Patients who underwent preoperative 18F-FDG PET/CT between 2006 and 2014 (n = 138) were stratified into high (≥ 4.85) and low (< 4.85) PET groups. The clinicopathological characteristics and prognostic outcomes were analyzed retrospectively...
February 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://read.qxmd.com/read/29103084/reinforced-staplers-for-distal-pancreatectomy
#18
MULTICENTER STUDY
Manabu Kawai, Seiko Hirono, Ken-Ichi Okada, Sohei Satoi, Hiroaki Yanagimoto, Masanori Kon, Yoshiaki Murakami, Naru Kondo, Masayuki Sho, Takahiro Akahori, Hirochika Toyama, Takumi Fukumoto, Tsutomu Fujii, Ippei Matsumoto, Hidetoshi Eguchi, Hisashi Ikoma, Yutaka Takeda, Jiro Fujimoto, Hiroki Yamaue
PURPOSE: The safety and efficacy of reinforced staplers during distal pancreatectomy (DP) remain controversial because of the small sample size. This multicenter single-arm prospective study aims to evaluate the safety and efficacy of reinforced staplers with bioabsorbable material during DP. METHODS: Between October 2014 and August 2015, 121 patients scheduled for DP were enrolled in this study at 11 institutions in Japan. The primary endpoint was the incidence of clinically relevant pancreatic fistula...
December 2017: Langenbeck's Archives of Surgery
https://read.qxmd.com/read/29099399/minimally-invasive-versus-open-distal-pancreatectomy-for-ductal-adenocarcinoma-diploma-a-pan-european-propensity-score-matched-study
#19
Jony van Hilst, Thijs de Rooij, Sjors Klompmaker, Majd Rawashdeh, Francesca Aleotti, Bilal Al-Sarireh, Adnan Alseidi, Zeeshan Ateeb, Gianpaolo Balzano, Frederik Berrevoet, Bergthor Björnsson, Ugo Boggi, Olivier R Busch, Giovanni Butturini, Riccardo Casadei, Marco Del Chiaro, Sophia Chikhladze, Federica Cipriani, Ronald van Dam, Isacco Damoli, Susan van Dieren, Safi Dokmak, Bjørn Edwin, Casper van Eijck, Jean-Marie Fabre, Massimo Falconi, Olivier Farges, Laureano Fernández-Cruz, Antonello Forgione, Isabella Frigerio, David Fuks, Francesca Gavazzi, Brice Gayet, Alessandro Giardino, Bas Groot Koerkamp, Thilo Hackert, Matthias Hassenpflug, Irfan Kabir, Tobias Keck, Igor Khatkov, Masa Kusar, Carlo Lombardo, Giovanni Marchegiani, Ryne Marshall, Krish V Menon, Marco Montorsi, Marion Orville, Matteo de Pastena, Andrea Pietrabissa, Ignaci Poves, John Primrose, Raffaele Pugliese, Claudio Ricci, Keith Roberts, Bård Røsok, Mushegh A Sahakyan, Santiago Sánchez-Cabús, Per Sandström, Lauren Scovel, Leonardo Solaini, Zahir Soonawalla, F Régis Souche, Robert P Sutcliffe, Guido A Tiberio, Aleš Tomazic, Roberto Troisi, Ulrich Wellner, Steven White, Uwe A Wittel, Alessandro Zerbi, Claudio Bassi, Marc G Besselink, Mohammed Abu Hilal
OBJECTIVE: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open distal pancreatectomy (ODP) in patients with pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: Cohort studies have suggested superior short-term outcomes of MIDP vs. ODP. Recent international surveys, however, revealed that surgeons have concerns about the oncological outcomes of MIDP for PDAC. METHODS: This is a pan-European propensity score matched study including patients who underwent MIDP (laparoscopic or robot-assisted) or ODP for PDAC between January 1, 2007 and July 1, 2015...
January 2019: Annals of Surgery
https://read.qxmd.com/read/29068800/the-impact-of-positive-resection-margins-on-survival-and-recurrence-following-resection-and-adjuvant-chemotherapy-for-pancreatic-ductal-adenocarcinoma
#20
Paula Ghaneh, Jorg Kleeff, Christopher M Halloran, Michael Raraty, Richard Jackson, James Melling, Owain Jones, Daniel H Palmer, Trevor F Cox, Chloe J Smith, Derek A O'Reilly, Jakob R Izbicki, Andrew G Scarfe, Juan W Valle, Alexander C McDonald, Ross Carter, Niall C Tebbutt, David Goldstein, Robert Padbury, Jennifer Shannon, Christos Dervenis, Bengt Glimelius, Mark Deakin, Alan Anthoney, Markus M Lerch, Julia Mayerle, Attila Oláh, Charlotte L Rawcliffe, Fiona Campbell, Oliver Strobel, Markus W Büchler, John P Neoptolemos
OBJECTIVE AND BACKGROUND: Local and distant disease recurrence are frequently observed following pancreatic cancer resection, but an improved understanding of resection margin assessment is required to aid tailored therapies. METHODS: Analyses were carried out to assess the association between clinical characteristics and margin involvement as well as the effects of individual margin involvement on site of recurrence and overall and recurrence-free survival using individual patient data from the European Study Group for Pancreatic Cancer (ESPAC)-3 randomized controlled trial...
March 2019: Annals of Surgery
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