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GU pathology

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55 papers 100 to 500 followers
By Sean Williamson Urologic Surgical Pathologist
Murali Varma, Brett Delahunt, Lars Egevad, Hemamali Samaratunga, Glen Kristiansen
Intraductal carcinoma of the prostate gland (IDCP), which is now categorised as a distinct entity by WHO 2016, includes two biologically distinct diseases. IDCP associated with invasive carcinoma (IDCP-inv) generally represents a growth pattern of invasive prostatic adenocarcinoma while the rarely encountered pure IDCP is a precursor of prostate cancer. This review highlights issues that require further discussion and clarification. The diagnostic criterion "nuclear size at least 6 times normal" is ambiguous as "size" could refer to either nuclear area or diameter...
March 1, 2019: Virchows Archiv: An International Journal of Pathology
Nicholas P Reder, Adam K Glaser, Erin F McCarty, Ye Chen, Lawrence D True, Jonathan T C Liu
CONTEXT.—: Ex vivo microscopy encompasses a range of techniques to examine fresh or fixed tissue with microscopic resolution, eliminating the need to embed the tissue in paraffin or produce a glass slide. One such technique is light-sheet microscopy, which enables rapid 3D imaging. Our pathology-engineering collaboration has resulted in an open-top light-sheet (OTLS) microscope that is specifically tailored to the needs of pathology practice. OBJECTIVE.—: To present an image atlas of OTLS images of prostate core needle biopsies...
March 20, 2019: Archives of Pathology & Laboratory Medicine
Wei Zheng, Abigail L Goodman, José E Velázquez Vega, Feng Yin, Kar-Ming Fung, Adeboye O Osunkoya
Brain metastases from renal cell carcinoma (RCC) are associated with significant morbidity and mortality. However, there are only few large series in the pathology literature specifically analyzing the clinicopathologic and immunohistochemical features in comparison with primary brain tumors with clear cell features. We identified 34 cases of metastatic RCC to the brain from the Urologic Pathology and Neuropathology files of 2 institutions between 2000 and 2018. Mean patient age at diagnosis of primary RCC was 59 years (range: 37 to 82 y)...
March 13, 2019: Applied Immunohistochemistry & Molecular Morphology: AIMM
Manuel L Gonzalez, Reza Alaghehbandan, Krystina Pivovarcikova, Kvetoslava Michalova, Joanna Rogala, Petr Martinek, María P Foix, Enric C Mundo, Eva Comperat, Monika Ulamec, Milan Hora, Michal Michal, Ondrej Hes
AIMS: Current available data on cytokeratin 7 (CK7) immunostaining pattern in the clear cell renal cell carcinoma (RCC) spectrum is conflicting. The aim of this study was to assess CK7 immunoreactivity within the spectrum of clear cell renal neoplasms, including clear cell RCC, multicystic renal neoplasm of low malignant potential and clear cell papillary RCC-like tumours. METHODS AND RESULTS: We analysed two clones of CK7 and two tumour blocks for a total of 75 cases divided into five distinct groups: (i) low-grade clear cell RCC, (ii) high-grade clear cell RCC, (iii) multicystic renal neoplasm of low malignant potential, (iv) clear cell RCC with cystic changes and (v) clear cell papillary RCC-like tumours...
March 2019: Histopathology
Nicole K Andeen, Xiaoyu Qu, Tatjana Antic, Scott S Tykodi, Min Fang, Maria S Tretiakova
CONTEXT.—: Cytogenomic analysis provides a useful adjunct to traditional pathology in the categorization of renal cell carcinomas (RCCs), particularly in morphologically ambiguous cases, but it has disadvantages, including cost. OBJECTIVE.—: To define the clinical scenarios in which this technology has direct clinical applications. DESIGN.—: DNA was isolated from paraffin-embedded tissue from 40 selected cases of RCC. Chromosome genomic array testing was performed using the OncoScan...
April 2019: Archives of Pathology & Laboratory Medicine
Leal Herlitz, Ondrej Hes, Michal Michal, Maria Tretiakova, Miguel Reyes-Múgica, Jane K Nguyen, Megan L Troxell, Christopher G Przybycin, Cristina Magi-Galluzzi, Jesse K McKenney
Renal mass lesions with a follicular architecture resembling atrophic kidney have been described, but their distinction from thyroid-like follicular carcinoma of the kidney remains controversial. We collected 8 cases of this purported "atrophic kidney"-like lesion to fully describe their clinical and histologic spectrum, their possible etiology, and to discuss their distinction from other renal neoplasms. Eight total cases were identified with patient ages ranging from 9 to 48 years (mean: 29 y; median: 28...
December 2018: American Journal of Surgical Pathology
Huiying He, Kiril Trpkov, Petr Martinek, Ozlem Tanas Isikci, Cristina Maggi-Galuzzi, Reza Alaghehbandan, Anthony J Gill, Maria Tretiakova, Jose Ignacio Lopez, Sean R Williamson, Delia Perez Montiel, Maris Sperga, Eva Comperat, Fadi Brimo, Ali Yilmaz, Kristyna Pivovarcikova, Kveta Michalova, David Slouka, Kristyna Prochazkova, Milan Hora, Michael Bonert, Michal Michal, Ondrej Hes
The spectrum of the renal oncocytic tumors has been expanded in recent years to include several novel and emerging entities. We describe a cohort of novel, hitherto unrecognized and morphologically distinct high-grade oncocytic tumors (HOT), currently diagnosed as "unclassified" in the WHO classification. We identified 14 HOT by searching multiple institutional archives. Morphologic, immunohistochemical (IHC), molecular genetic, and molecular karyotyping studies were performed to investigate these tumors...
December 2018: Virchows Archiv: An International Journal of Pathology
Gang Wang, Jesse K McKenney
CONTEXT: - Since the publication of the previous World Health Organization (WHO) Classification of Tumours on the Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs in 2004, significant new knowledge has been generated regarding the pathology and genetics of bladder neoplasia. Publication of the 2016 WHO "Blue Book" has codified that new data into updated recommendations for classification and prognostication. Similarly, the recent release of the 8th edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual, which was implemented in January 2018, has also addressed staging criteria for bladder cancer in several unique settings to clarify their application...
July 25, 2018: Archives of Pathology & Laboratory Medicine
Thomas K Lee, Jae Y Ro
CONTEXT: - The presence of cribriform glands/ducts in the prostate can pose a diagnostic challenge. Cribriform glands/ducts include a spectrum of lesions, from benign to malignant, with vastly different clinical, prognostic, and treatment implications. OBJECTIVE: - To highlight the diagnostic features of several entities with a common theme of cribriform architecture. We emphasize the importance of distinguishing among benign entities such as cribriform changes and premalignant to malignant entities such as high-grade prostatic intraepithelial neoplasia, atypical intraductal cribriform proliferation, intraductal carcinoma of the prostate, and invasive adenocarcinoma (acinar and ductal types)...
August 2018: Archives of Pathology & Laboratory Medicine
T Maubon, N Branger, C Bastide, G Lonjon, K-A Harvey-Bryan, P Validire, S Giusiano, D Rossi, X Cathelineau, F Rozet
BACKGROUND: To assess the impact of the degree of extraprostatic extension (EPE) on biochemical recurrence (BCR) and utility of the original Epstein's criteria to define EPE in a cohort of pT3aN0 without positive surgical margin (PSM). METHODS: A two-center retrospective analysis was performed on data from 490 pT3aN0 patients who underwent radical prostatectomy between 2000 and 2012. Patients with neoadjuvant and/or adjuvant therapy, detectable PSA and PSM were excluded...
September 2016: Prostate Cancer and Prostatic Diseases
Bruce J Trock, Helen Fedor, Bora Gurel, Robert B Jenkins, B S Knudsen, Samson W Fine, Jonathan W Said, H Ballentine Carter, Tamara L Lotan, Angelo M De Marzo
Men who enter active surveillance because their biopsy exhibits only Gleason grade 3 (G3) frequently have higher grade tumor missed by biopsy. Thus, biomarkers are needed that, when measured on G3 tissue, can predict the presence of higher grade tumor in the whole prostate. We evaluated whether PTEN loss, chromosome 8q gain (MYC) and/or 8p loss (LPL) measured only on G3 cores is associated with un-sampled G4 tumor. A tissue microarray was constructed of prostatectomy tissue from patients whose prostates exhibited only Gleason score 3+3, only 3+4 or only 4+3 tumor (n=50 per group)...
July 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Ikuma Kato, Yasuhiro Iribe, Yoji Nagashima, Naoto Kuroda, Reiko Tanaka, Yukio Nakatani, Hisashi Hasumi, Masahiro Yao, Mitsuko Furuya
Birt-Hogg-Dubé syndrome (BHD) is a familial disorder associated with a germline mutation of FLCN that is a tumor suppressor gene. Patients with BHD have high risks for developing multiple renal cell carcinomas (RCCs). The frequent histological types are hybrid oncocytic/chromophobe tumors (HOCTs) and chromophobe RCCs. The morphology of HOCTs could alert pathologists to the possibility of BHD. On the other hand, chromophobe RCCs occurring in BHD patients demonstrate positive immunostaining for cytokeratin-7, CD82, and Ksp-cadherin similar to their sporadic counterparts...
June 2016: Human Pathology
Evita T Sadimin, Jonathan I Epstein
Prostatic stromal tumor of uncertain malignant potential (STUMP) is a distinct entity which includes several different patterns. Four patterns of STUMP have been described including stroma with (1) degenerative atypia, (2) hypercellular spindle cells, (3) myxoid spindle cells, and (4) phyllodes-like pattern. The current study identified a novel round cell pattern. We searched our database from 1999 to 2015 and identified 7 patients with round cell pattern out of a total number of 98 patients with STUMP. All 7 cases showed mildly increased stromal cellularity with rounded nuclei, diagnosed on core biopsies in 5 cases, transurethral resection in 1 case, and radical prostatectomy in 1 case...
June 2016: Human Pathology
Rajal B Shah, Ming Zhou
Since its initial description in 1966 by Dr Donald Gleason, Gleason grading has become the cornerstone in the management of prostate cancer (PCa). With widespread use of Prostate Specific Antigen (PSA) screening and needle core biopsy, the diagnosis and management of PCa have dramatically evolved. In addition, better understanding of the morphological spectrum of prostate cancer and its clinical significance have prompted the refinement of the grading criteria and reporting guidelines commensurate to contemporary practice...
May 2016: Pathology International
Pedram Argani, Minghao Zhong, Victor E Reuter, John T Fallon, Jonathan I Epstein, George J Netto, Cristina R Antonescu
Xp11 translocation cancers include Xp11 translocation renal cell carcinoma (RCC), Xp11 translocation perivascular epithelioid cell tumor (PEComa), and melanotic Xp11 translocation renal cancer. In Xp11 translocation cancers, oncogenic activation of TFE3 is driven by the fusion of TFE3 with a number of different gene partners; however, the impact of individual fusion variant on specific clinicopathologic features of Xp11 translocation cancers has not been well defined. In this study, we analyze 60 Xp11 translocation cancers by fluorescence in situ hybridization using custom bacterial artificial chromosome probes to establish their TFE3 fusion gene partner...
June 2016: American Journal of Surgical Pathology
Sara M Falzarano, Jesse K McKenney, Rodolfo Montironi, John N Eble, Adeboye O Osunkoya, Juan Guo, Shengmei Zhou, Hong Xiao, Saravana M Dhanasekaran, Sudhanshu Shukla, Rohit Mehra, Cristina Magi-Galluzzi
Renal cell carcinoma (RCC) associated with neuroblastoma (NB) was included as a distinct entity in the 2004 World Health Organization classification of kidney tumors. A spectrum of RCC subtypes has been reported in NB survivors. We herein describe a series of 8 RCCs diagnosed in 7 patients with a history of NB. Microscopic evaluation, immunohistochemical staining for PAX8, cathepsin K, and succinate dehydrogenase subunit B (SDHB), and fluorescence in situ hybridization (FISH) for TFE3 and TFEB were performed...
July 2016: American Journal of Surgical Pathology
Guang-Qian Xiao, Faqian Li, Pamela D Unger, Hani Katerji, Qi Yang, Loralee McMahon, David E Burstein
Although the function of zinc finger and BTB domain containing 16 (ZBTB16) in spermatogenesis is well documented, expression of ZBTB16 in germ cell tumors has not yet been studied. The aim of this study was to investigate the immunohistochemical expression and diagnostic utility of ZBTB16 in germ cell tumors. A total of 67 adult germ cell tumors were studied (62 testicular germ cell tumors, 2 ovarian yolk sac tumors, 1 mediastinal yolk sac tumor, and 2 retroperitoneal metastatic yolk sac tumors). The 62 testicular primary germ cell tumors are as follows: 34 pure germ cell tumors (20 seminomas, 8 embryonal carcinomas, 2 teratomas, 1 choriocarcinoma, 1 carcinoid, and 2 spermatocytic tumors) and 28 mixed germ cell tumors (composed of 13 embryonal carcinomas, 15 yolk sac tumors, 15 teratomas, 7 seminomas, and 3 choriocarcinomas in various combinations)...
June 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Martin J Magers, Aaron M Udager, Arul M Chinnaiyan, Diana French, Jeffrey L Myers, Jeffrey M Jentzen, Jonathan B McHugh, Amer Heider, Rohit Mehra
The immunophenotype of a normal testis and the excretory duct system has not been studied comprehensively in fetal and adult patients without testicular disease or hormonal manipulation so far. In addition, testicular (TA) and epididymal (EA) appendages are frequent paratesticular structures without previously reported comprehensive immunophenotypic studies. Immunohistochemistry for multiple markers, including the androgen receptor (AR), the estrogen receptor (ER), the progesterone receptor (PR), the prostate-specific antigen, the prostate-specific membrane antigen, PAX8, WT1, calretinin, CK7, CK20, OCT4, SALL4, and CD117, was performed on full sections of testicular/paratesticular tissue from a large cohort of adult and fetal autopsy patients...
August 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
Gladell P Paner, Antonio Lopez-Beltran, Deepika Sirohi, Mahul B Amin
Since the publication of the World Health Organization "blue book" in 2004, several recent studies have provided new insights on the pathologic aspects of urachal neoplasms. The proposed updates include modified criteria for the diagnosis of urachal carcinoma. A uniform nomenclature for cystic tumors was lacking, and it is recommended that urachal mucinous cystic tumors should be separated and classified in a manner similar to ovarian mucinous neoplasms. The spectrum includes mucinous cystadenoma, mucinous cystic tumor of low malignant potential, mucinous cystic tumor of low malignant potential with intraepithelial carcinoma, and microscopically or frankly invasive mucinous cystadenocarcinoma, with 65% of cystic tumors classified as mucinous cystic tumor of low malignant potential...
March 2016: Advances in Anatomic Pathology
Hironori Kusano, Yuki Togashi, Jun Akiba, Fukuko Moriya, Katsuyoshi Baba, Naomi Matsuzaki, Yoshiaki Yuba, Yusuke Shiraishi, Hiroshi Kanamaru, Naoto Kuroda, Seiji Sakata, Kengo Takeuchi, Hirohisa Yano
Anaplastic lymphoma kinase (ALK) translocation renal cell carcinomas (RCCs) have been reported by several independent groups in recent times. The clinical behavior and histopathologic characteristics of these carcinomas are not fully understood because of the paucity of cases reported. Here, we describe 2 cases of RCC harboring a novel striatin (STRN)-ALK fusion. The first case was a 33-year-old woman with no sickle cell trait who underwent nephrectomy for right renal mass and had late recurrence in para-aortic lymph nodes twice 10 and 12 years after initial surgery...
June 2016: American Journal of Surgical Pathology
2016-02-13 18:03:34
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