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Guidelines paeds

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Lissy de Ridder, Matti Waterman, Dan Turner, Jiri Bronsky, Almuthe C Hauer, Jorge A Dias, Caterina Strisciuglio, Frank M Ruemmele, Arie Levine, Paolo Lionetti
Because the patents for biopharmaceutical monoclonal antibodies have or soon will expire, biosimilars are coming to the market. This will most likely lead to decreased drug costs and so easier access to these expensive agents. Extrapolation, however, of the limited available clinical data from adults with rheumatologic diseases to children with inflammatory bowel disease (IBD) should be done with caution and needs some considerations.Postmarketing surveillance programs for efficacy, safety, and immunogenicity should become mandatory in children with IBD using biosimilars, as for all biological drugs...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
R B Heuschkel, F Gottrand, K Devarajan, H Poole, J Callan, J A Dias, S Karkelis, A Papadopoulou, S Husby, F Ruemmele, M G Schäppi, M Wilschanski, P Lionetti, R Orel, J Tovar, N Thapar, Y Vandenplas
OBJECTIVES: This European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) position statement provides a comprehensive guide for health care providers to manage percutaneous endoscopic gastrostomy tubes in a safe, effective, and appropriate way. METHODS: Relevant literature from searches of PubMed, CINAHL, and recent guidelines was reviewed. In the absence of evidence, recommendations reflect the expert opinion of the authors. Final consensus was obtained by multiple e-mail exchange and during 3 face-to-face meetings of the gastroenterology committee of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition...
January 2015: Journal of Pediatric Gastroenterology and Nutrition
Kathryn N North, Ching H Wang, Nigel Clarke, Heinz Jungbluth, Mariz Vainzof, James J Dowling, Kimberly Amburgey, Susana Quijano-Roy, Alan H Beggs, Caroline Sewry, Nigel G Laing, Carsten G Bönnemann
Over the past decade there have been major advances in defining the genetic basis of the majority of congenital myopathy subtypes. However the relationship between each congenital myopathy, defined on histological grounds, and the genetic cause is complex. Many of the congenital myopathies are due to mutations in more than one gene, and mutations in the same gene can cause different muscle pathologies. The International Standard of Care Committee for Congenital Myopathies performed a literature review and consulted a group of experts in the field to develop a summary of (1) the key features common to all forms of congenital myopathy and (2) the specific features that help to discriminate between the different genetic subtypes...
February 2014: Neuromuscular Disorders: NMD
Shawn L Ralston, Allan S Lieberthal, H Cody Meissner, Brian K Alverson, Jill E Baley, Anne M Gadomski, David W Johnson, Michael J Light, Nizar F Maraqa, Eneida A Mendonca, Kieran J Phelan, Joseph J Zorc, Danette Stanko-Lopp, Mark A Brown, Ian Nathanson, Elizabeth Rosenblum, Stephen Sayles, Sinsi Hernandez-Cancio
This guideline is a revision of the clinical practice guideline, "Diagnosis and Management of Bronchiolitis," published by the American Academy of Pediatrics in 2006. The guideline applies to children from 1 through 23 months of age. Other exclusions are noted. Each key action statement indicates level of evidence, benefit-harm relationship, and level of recommendation. Key action statements are as follows:
November 2014: Pediatrics
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