Stefan Leucht, Andrea Cipriani, Loukia Spineli, Dimitris Mavridis, Deniz Orey, Franziska Richter, Myrto Samara, Corrado Barbui, Rolf R Engel, John R Geddes, Werner Kissling, Marko Paul Stapf, Bettina Lässig, Georgia Salanti, John M Davis
BACKGROUND: The question of which antipsychotic drug should be preferred for the treatment of schizophrenia is controversial, and conventional pairwise meta-analyses cannot provide a hierarchy based on the randomised evidence. We aimed to integrate the available evidence to create hierarchies of the comparative efficacy, risk of all-cause discontinuation, and major side-effects of antipsychotic drugs. METHODS: We did a Bayesian-framework, multiple-treatments meta-analysis (which uses both direct and indirect comparisons) of randomised controlled trials to compare 15 antipsychotic drugs and placebo in the acute treatment of schizophrenia...
September 14, 2013: Lancet