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By Vicente Bebia OB/GYN Residente Hospital 12 de Octubre, Madrid
Agnieszka Seremak-Mrozikiewicz, Anna Bogacz, Joanna Bartkowiak-Wieczorek, Hubert Wolski, Boguslaw Czerny, Malgorzata Gorska-Paukszta, Krzysztof Drews
OBJECTIVE: Preeclampsia (PE) is a major cause of maternal and perinatal mortality and morbidity. The studies suggest that both polymorphisms and changes of expression in genes encoding enzymes involved in the methionine and homocysteine metabolism (MHM), such as methylenetetrahydrofolate, reductase (MTHFR), methionine synthase (MTR), methionine synthase reductase (MTRR) and cystathionine gamma-lyase (CSE), could play a role in the development of hypertension during pregnancy. The aim of the study was to determine the expression level of MTHFR, MTR, MTRR and CSE genes in the development of PE in Caucasian women...
May 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
C Fox, K S Khan, A Coomarasamy
The methodology to evaluate either a test or treatment is well developed and understood. However, the design, conduct and interpretation of a combination of a test and a treatment in a single study are fraught with complexities. There are two distinct study designs to evaluate test-treatment combinations, with randomisation occurring either before or after the test. We present critical issues that need to be considered when evaluating and appraising test-treatment combinations, using the example of research on the uterine artery Doppler test to predict, and aspirin to prevent, pre-eclampsia...
June 2010: BJOG: An International Journal of Obstetrics and Gynaecology
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