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Neurobiology of Aggression

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4 papers 100 to 500 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
Larry J Siever
Acts of violence account for an estimated 1.43 million deaths worldwide annually. While violence can occur in many contexts, individual acts of aggression account for the majority of instances. In some individuals, repetitive acts of aggression are grounded in an underlying neurobiological susceptibility that is just beginning to be understood. The failure of "top-down" control systems in the prefrontal cortex to modulate aggressive acts that are triggered by anger provoking stimuli appears to play an important role...
April 2008: American Journal of Psychiatry
Klaus A Miczek, Rosa M M de Almeida, Edward A Kravitz, Emilie F Rissman, Sietse F de Boer, Adrian Raine
Psychopathological violence in criminals and intense aggression in fruit flies and rodents are studied with novel behavioral, neurobiological, and genetic approaches that characterize the escalation from adaptive aggression to violence. One goal is to delineate the type of aggressive behavior and its escalation with greater precision; second, the prefrontal cortex (PFC) and brainstem structures emerge as pivotal nodes in the limbic circuitry mediating escalated aggressive behavior. The neurochemical and molecular work focuses on the genes that enable invertebrate aggression in males and females and genes that are expressed or suppressed as a result of aggressive experiences in mammals...
October 31, 2007: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Evelien Platje, Arne Popma, Robert R J M Vermeiren, Theo A H Doreleijers, Wim H J Meeus, Pol A C van Lier, Hans M Koot, Susan J T Branje, Lucres M C Jansen
Testosterone and cortisol have been proposed to jointly regulate aggressive behavior. However, few empirical studies actually investigated this joint relation in humans, and reported inconsistent findings. Also, samples in these studies were small and/or specific, and consisted largely of males. Therefore, in the current study testosterone and cortisol in relation to aggression were investigated in a non-clinical sample of 259 boys and girls (mean age 16.98 years, SD = 0.42, 56% boys). A positive testosterone/cortisol ratio, that is, high testosterone relative to cortisol, was found to be associated with aggressive behavior, explaining 7% of the variance...
September 2015: Aggressive Behavior
Macià Buades-Rotger, David Gallardo-Pujol
Hereditary factors are increasingly attracting the interest of behavioral scientists and practitioners. Our aim in the present article is to introduce some state-of-the-art topics in behavioral genetics, as well as selected findings in the field, in order to illustrate how genetic makeup can modulate the impact of environmental factors. We focus on the most-studied polymorphism to date for antisocial responses to adversity: the monoamine oxidase A gene. Advances, caveats, and promises of current research are reviewed...
2014: Psychology Research and Behavior Management
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