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Anxiety disorders

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12 papers 500 to 1000 followers
By Abraham Nunes Psychiatry resident interested in computational neuroscience, forensic psychiatry, and neuropsychiatry.
Michelle G Craske, Murray B Stein
Anxiety disorders (separation anxiety disorder, selective mutism, specific phobias, social anxiety disorder, panic disorder, agoraphobia, and generalised anxiety disorder) are common and disabling conditions that mostly begin during childhood, adolescence, and early adulthood. They differ from developmentally normative or stress-induced transient anxiety by being marked (ie, out of proportion to the actual threat present) and persistent, and by impairing daily functioning. Most anxiety disorders affect almost twice as many women as men...
December 17, 2016: Lancet
Rita A Watterson, Jeanne V A Williams, Dina H Lavorato, Scott B Patten
OBJECTIVE: The first national survey to assess the prevalence of generalized anxiety disorder (GAD) in Canada was the 2012 Canadian Community Health Survey: Mental Health and Well-Being (CCHS-MH). The World Mental Health Composite International Diagnostic Interview (WMH-CIDI), used within the representative sample of the CCHS-MH, provides the best available description of the epidemiology of this condition in Canada. This study uses the CCHS-MH data to describe the epidemiology of GAD...
January 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Jasmijn M de Lijster, Bram Dierckx, Elisabeth M W J Utens, Frank C Verhulst, Carola Zieldorff, Gwen C Dieleman, Jeroen S Legerstee
OBJECTIVE: The objective was to estimate the age of onset (AOO) for all anxiety disorders and for specific subtypes. Gender differences in the AOO of anxiety disorders were examined, as were the influence of study characteristics on reported AOOs. METHODS: Seven electronic databases were searched up to October 2014, with keywords representing anxiety disorder subtypes, AOO, and study design. The inclusion criteria were studies using a general population sample that provided data on the AOO for all anxiety disorders, or specific anxiety disorders, according to DSM-III-R, DSM-IV, or ICD-10 criteria...
April 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Murray B Stein, Jitender Sareen
No abstract text is available yet for this article.
November 19, 2015: New England Journal of Medicine
Philip Tovote, Jonathan Paul Fadok, Andreas L├╝thi
Decades of research has identified the brain areas that are involved in fear, fear extinction, anxiety and related defensive behaviours. Newly developed genetic and viral tools, optogenetics and advanced in vivo imaging techniques have now made it possible to characterize the activity, connectivity and function of specific cell types within complex neuronal circuits. Recent findings that have been made using these tools and techniques have provided mechanistic insights into the exquisite organization of the circuitry underlying internal defensive states...
June 2015: Nature Reviews. Neuroscience
Rebecca L Schneider, Joanna J Arch, Kate B Wolitzky-Taylor
INTRODUCTION: The aim of this review was to synthesize findings for moderators of treatment outcome across adult anxiety disorders, obsessive-compulsive disorder, and posttraumatic stress disorder. METHODS: Twenty-four papers that compared two or more active treatments (at least one of which was a form of cognitive behavioral therapy [CBT]) were identified and organized into five treatment comparison categories (distinct psychotherapy combinations, CBT full package vs...
June 2015: Clinical Psychology Review
Jessica A Eccles, Andrew P Owens, Christopher J Mathias, Satoshi Umeda, Hugo D Critchley
This review explores the proposal that vulnerability to psychological symptoms, particularly anxiety, originates in constitutional differences in the control of bodily state, exemplified by a set of conditions that include Joint Hypermobility, Postural Tachycardia Syndrome and Vasovagal Syncope. Research is revealing how brain-body mechanisms underlie individual differences in psychophysiological reactivity that can be important for predicting, stratifying and treating individuals with anxiety disorders and related conditions...
2015: Frontiers in Neuroscience
Courtney Benjamin Wolk, Philip C Kendall, Rinad S Beidas
OBJECTIVE: Evidence for an independent relationship between anxiety and suicidality has been mixed. Few studies have examined this relationship in youth seeking treatment for anxiety. The present study examined the relationship between response to treatment for an anxiety disorder in childhood and suicidal ideation, plans, and attempts at a follow-up interval of 7 to 19 years. We hypothesized that successful treatment for an anxiety disorder in childhood would be protective against later suicidality...
March 2015: Journal of the American Academy of Child and Adolescent Psychiatry
Janice H Goodman, Kerry L Chenausky, Marlene P Freeman
OBJECTIVE: To systematically evaluate the literature on anxiety disorders during pregnancy. DATA SOURCES: MEDLINE, PsycINFO, and CINAHL were searched through October 2013 for original research studies published in English using combinations of the terms pregnancy, prenatal, or pregnancy outcomes; anxiety disorder; and generalized anxiety. Reference lists of included studies were hand-searched and a PubMed search for in-process reports was conducted. STUDY SELECTION: Relevant studies of anxiety disorders during pregnancy as determined by diagnostic interview were included if they reported on prevalence; course, onset, and/or risk factors; maternal, obstetric, or fetal/child outcomes; and/or treatment trial results...
October 2014: Journal of Clinical Psychiatry
David M Bannerman, Rolf Sprengel, David J Sanderson, Stephen B McHugh, J Nicholas P Rawlins, Hannah Monyer, Peter H Seeburg
Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety...
March 2014: Nature Reviews. Neuroscience
Dan W Grupe, Jack B Nitschke
Uncertainty about a possible future threat disrupts our ability to avoid it or to mitigate its negative impact and thus results in anxiety. Here, we focus the broad literature on the neurobiology of anxiety through the lens of uncertainty. We identify five processes that are essential for adaptive anticipatory responses to future threat uncertainty and propose that alterations in the neural instantiation of these processes result in maladaptive responses to uncertainty in pathological anxiety. This framework has the potential to advance the classification, diagnosis and treatment of clinical anxiety...
July 2013: Nature Reviews. Neuroscience
Nastassja Koen, Dan J Stein
Given the enormous contribution of anxiety disorders to the burden of disease, it is key to optimize their prevention and treatment. In this critical review we assess advances in the pharmacotherapy of anxiety disorders, as well as remaining challenges, in recent decades, the field has seen rigorous clinical trial methods to quantify the efficacy and safety of serendipitously discovered agents, more focused development of medications with selective mechanisms of action, and the gradual translation of insights from laboratory research into proof-of-principle clinical trials...
2011: Dialogues in Clinical Neuroscience
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