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Glucose sensing

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8 papers 0 to 25 followers Brain glucose sensing /relevant literature
Tran Duy Thanh, Jayaraman Balamurugan, Seung Hee Lee, Nam Hoon Kim, Joong Hee Lee
A novel gold nanoparticle-anchored nitrogen-doped graphene (AuNP/NG) nanohybrid was synthesized through a seed-assisted growth method, as an effective electrocatalyst for glucose and dopamine detection. The AuNP/NG nanohybrids exhibited high sensitivity and selectivity toward glucose and dopamine sensing applications. The as-synthesized nanohybrids exhibited excellent catalytic activity toward glucose, with a linear response throughout the concentration range from 40μM to 16.1mM, a detection limit of 12μM, and a short response time (∼ 10s)...
July 15, 2016: Biosensors & Bioelectronics
Eugene A Kiyatkin, Ken T Wakabayashi
Extracellular levels of glucose in brain tissue reflect dynamic balance between its gradient-dependent entry from arterial blood and its use for cellular metabolism. In this work, we present several sets of previously published and unpublished data obtained by using enzyme-based glucose biosensors coupled with constant-potential high-speed amperometry in freely moving rats. First, we consider basic methodological issues related to the reliability of electrochemical measurements of extracellular glucose levels in rats under physiologically relevant conditions...
January 21, 2015: ACS Chemical Neuroscience
Hakan Ciftci, Yasemin Oztekin, Ugur Tamer, Almira Ramanaviciene, Arunas Ramanavicius
This study is focused on the investigation of electrocatalytic effect of glucose oxidase (GOx) immobilized on the graphite rod (GR) electrode. The enzyme modified electrode was prepared by encapsulation of immobilized GOx within enzymatically formed poly(1,10-phenanthroline-5,6-dione) (pPD) film. The electrochemical responses of such enzymatic electrode (pPD/GOx/GR) vs. different glucose concentrations were examined chronoamperometrically in acetate-phosphate buffer solution (A-PBS), pH 6.0, under aerobic or anaerobic conditions...
November 1, 2014: Colloids and Surfaces. B, Biointerfaces
Aliakbar Tarlani, Mahtab Fallah, Behzad Lotfi, Avideh Khazraei, Sommayeh Golsanamlou, Jacques Muzart, Maryam Mirza-Aghayan
In a new approach, shape controlled synthesis of zinc oxide nanostructures were carried out using a solvothermal route assisted amino acids such as L-Lysine (lysine), L-Cysteine (cysteine) and L-Arginine (arginine) as bifunctional species with (or without) urea or oxalic acid as additives which affect the pH of the reaction. Rod, powder, particle, cube, rock candy-like, sheet, sphere, brain-like, groundnut-like and pussy willow-like morphologies were obtained through the synthetic route. Particle sizes varied from 25 nm to4 μm...
May 15, 2015: Biosensors & Bioelectronics
Abdulazeez T Lawal
This review summarises the most recent contributions in the fabrication of graphene-based electrochemical biosensors in recent years. It discusses the synthesis and application of graphene to the fabrication of graphene-based electrochemical sensors, its analytical performance and future prospects. An increasing number of reviews and publications involving graphene sensors have been reported ever since the first design of graphene electrochemical biosensor. The large surface area and good electrical conductivity of graphene allow it to act as an "electron wire" between the redox centres of an enzyme or protein and an electrode's surface, which make it a very excellent material for the design of electrochemical biosensors...
January 2015: Talanta
Hua Li, Chun-Yan Guo, Cai-Ling Xu
Bimetallic Cu-Ag superstructures were successfully fabricated for the first time by using the natural leaves as reducing agent through a facile one-step hydrothermal process. Morphology, structure and composition of the Cu-Ag superstructures were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectra (XPS) and inductively coupled plasma-optical emission spectroscopy (ICP-OES), respectively. The results reveal that the Cu-Ag superstructure is bimetallic nanocomposite constructed by nanoparticles with low Ag content and shows a rough surface and porous flexural algae-like microstructure...
January 15, 2015: Biosensors & Bioelectronics
Melisa del Barrio, Susana de Marcos, Vicente Cebolla, Josef Heiland, Stefan Wilhelm, Thomas Hirsch, Javier Galbán
A new approach for the design of a fluorometric biosensor for continuous monitoring of glucose levels in biological samples based on near-infrared (NIR) excitation is described. The sensor combines the fluorescence of the enzyme glucose oxidase (GOx) chemically modified with a fluorescein derivative (FS) and the luminescent properties of upconverting luminescent nanoparticles (UCLNPs). Both, the chemically modified enzyme (GOx-FS) and the UCLNPs are immobilized in a poly(acrylamide) film as a physical support...
September 15, 2014: Biosensors & Bioelectronics
Jyoti C Patel, Margaret E Rice
Here we review evidence that the reactive oxygen species, hydrogen peroxide (H(2)O(2)), meets the criteria for classification as a neuromodulator through its effects on striatal dopamine (DA) release. This evidence was obtained using fast-scan cyclic voltammetry to detect evoked DA release in striatal slices, along with whole-cell and fluorescence imaging to monitor cellular activity and H(2)O(2) generation in striatal medium spiny neurons (MSNs). The data show that (1) exogenous H(2)O(2) suppresses DA release in dorsal striatum and nucleus accumbens shell and the same effect is seen with elevation of endogenous H(2)O(2) levels; (2) H(2)O(2) is generated downstream from glutamatergic AMPA receptor activation in MSNs, but not DA axons; (3) generation of modulatory H(2)O(2) is activity dependent; (4) H(2)O(2) generated in MSNs diffuses to DA axons to cause transient DA release suppression by activating ATP-sensitive K(+) (K(ATP)) channels on DA axons; and (5) the amplitude of H(2)O(2)-dependent inhibition of DA release is attenuated by enzymatic degradation of H(2)O(2), but the subsecond time course is determined by H(2)O(2) diffusion rate and/or K(ATP)-channel kinetics...
December 19, 2012: ACS Chemical Neuroscience
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