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REVIEW
Elvira Isganaitis, Robert H Lustig
Rates of obesity and insulin resistance have climbed sharply over the past 30 years. These epidemics are temporally related to a dramatic rise in consumption of fast food; until recently, it was not known whether the fast food was driving the obesity, or vice versa. We review the unique properties of fast food that make it the ideal obesigenic foodstuff, and elucidate the mechanisms by which fast food intake contributes to obesity, emphasizing its effects on energy metabolism and on the central regulation of appetite...
December 2005: Arteriosclerosis, Thrombosis, and Vascular Biology
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JOURNAL ARTICLE
Katherine J Dick, Christopher P Nelson, Loukia Tsaprouni, Johanna K Sandling, Dylan Aïssi, Simone Wahl, Eshwar Meduri, Pierre-Emmanuel Morange, France Gagnon, Harald Grallert, Melanie Waldenberger, Annette Peters, Jeanette Erdmann, Christian Hengstenberg, Francois Cambien, Alison H Goodall, Willem H Ouwehand, Heribert Schunkert, John R Thompson, Tim D Spector, Christian Gieger, David-Alexandre Trégouët, Panos Deloukas, Nilesh J Samani
BACKGROUND: Obesity is a major health problem that is determined by interactions between lifestyle and environmental and genetic factors. Although associations between several genetic variants and body-mass index (BMI) have been identified, little is known about epigenetic changes related to BMI. We undertook a genome-wide analysis of methylation at CpG sites in relation to BMI. METHODS: 479 individuals of European origin recruited by the Cardiogenics Consortium formed our discovery cohort...
June 7, 2014: Lancet
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