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Cml sokal score

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5 papers 0 to 25 followers
By Shair Zaman Medical graduate now doing specialisation in medicine
Noriyoshi Iriyama, Yoshihiro Hatta, Sumiko Kobayashi, Yoshihito Uchino, Katsuhiro Miura, Daisuke Kurita, Hitomi Kodaira, Mitsuru Inoue, Masami Takei
The introduction of tyrosine kinase inhibitors has dramatically improved outcomes for many patients with chronic myeloid leukemia (CML), but some cases are resistant to this treatment. To compare the prognostic performance of Sokal, Hasford, and European Treatment and Outcome Study (EUTOS) scores, patient outcomes and treatment responses were investigated following the European LeukemiaNet (ELN) 2013 recommendations. Seventy-three patients with newly diagnosed chronic-phase CML (CML-CP) treated with any tyrosine kinase inhibitor as initial therapy were analyzed...
October 2014: International Journal of Hematology
Joerg Hasford, Michele Baccarani, Verena Hoffmann, Joelle Guilhot, Susanne Saussele, Gianantonio Rosti, François Guilhot, Kimmo Porkka, Gert Ossenkoppele, Doris Lindoerfer, Bengt Simonsson, Markus Pfirrmann, Rudiger Hehlmann
The outcome of chronic myeloid leukemia (CML) has been profoundly changed by the introduction of tyrosine kinase inhibitors into therapy, but the prognosis of patients with CML is still evaluated using prognostic scores developed in the chemotherapy and interferon era. The present work describes a new prognostic score that is superior to the Sokal and Euro scores both in its prognostic ability and in its simplicity. The predictive power of the score was developed and tested on a group of patients selected from a registry of 2060 patients enrolled in studies of first-line treatment with imatinib-based regimes...
July 21, 2011: Blood
Burak Uz, Yahya Buyukasik, Hilmi Atay, Engin Kelkitli, Mehmet Turgut, Ozlen Bektas, Eylem Eliacik, Ayşe Isik, Salih Aksu, Hakan Goker, Nilgun Sayinalp, Osman I Ozcebe, Ibrahim C Haznedaroglu
OBJECTIVES: The validity of the three currently used chronic myeloid leukemia (CML) scoring systems (Sokal CML prognostic scoring system, Euro/Hasford CML scoring system, and the EUTOS CML prognostic scoring system) were compared in the CML patients receiving frontline imatinib mesylate. PATIENTS AND METHODS: One hundred and fourty-three chronic phase CML patients (71 males, 72 females) taking imatinib as frontline treatment were included in the study. The median age was 44 (16-82) years...
September 2013: Hematology (Amsterdam, Netherlands)
Gege Feng, Jianhong Wang, Yujie Jiang, Ying Li, Mei Ding, Na Wang, Xin Wang
OBJECTIVE: To compare the validity of three currently used chronic myeloid leukemia (CML) scoring systems (Sokal CML prognostic scoring system, Hasford prognostic scoring system, and EUTOS prognostic scoring system) in chronic phase CML (CP-CML) patients. METHODS: One hundred and thirteen CP-CML patients taking hydroxyurea, interferon or imatinib were enrolled in this study. All patients were stratified into different groups according to each scoring system and different therapies respectively...
August 2014: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
Seung-Ah Yahng, Eun-Jung Jang, Soo-Young Choi, Sung-Eun Lee, Soo-Hyun Kim, Dong-Wook Kim
Beyond the conventional Sokal and Euro scores, a new prognostic risk classification, based on the European Treatment Outcome Study (EUTOS), has been developed to predict the outcome of treatment with tyrosine kinase inhibitors (TKI) in chronic myeloid leukemia (CML). In the present study, each risk score was validated by various endpoints in 206 Korean patients with early chronic-phase CML treated with up-front standard dose imatinib. In our analysis, all three scores were found to be valid. The 5-year event-free survival (EFS) was significantly discriminated using Sokal (P = 0...
August 2014: International Journal of Hematology
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